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Publications

Latest Publications

  • Beanlands RSB, Nichol G, Huszti E, Humen D, Racine N, Freeman M, Gulenchyn KY, Garrard L, deKemp R, Gao A, Ruddy TD, Benard F, Lamy A, Iwanochko RM and the PARR2 Investigators. F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients with Severe Left Ventricular Dysfunction and Suspected Coronary Disease. A Randomized Controlled rial (PARR-2). J Am Coll Cardiol ; 2007 Nov 13;50(20):2002-12
  • *Youssef, et al. The Use of FDG-18 PET Imaging in the Diagnosis of Cardiac Sarcoidosis, a Systematic Review and Meta-analysis Including the Ontario Experience. J Nucl Med. ‘12;53:241-8.
  • *Valdivia, et al. A fast, simple and reproducible automated synthesis of [18F]FPyKYNE-c(RGDyK) for alphavbeta3 receptor PET imaging. J Label Cpd Radiopharm. ‘12;55:57-60
  • *McArdle, et al. Does Rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease? JACC ‘12;60:1828-37
  • *Thorn, et al. Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model. EJNMMI Res ‘13;3:48
  • O’Meara, et al.; Paterson, et al.; Chow, et al. IMAGE-HF Trial Designs – Projects 1A, 1B, 1C (Trials 2013;14:218; Trials '13;14:332; Trials ‘14;13:443)
  • *Mc Ardle, et al. Is There an Association Between Clinical Presentation and the Location and Extent of Myocardial Involvement of Cardiac Sarcoidosis as Assessed by 18F-FDG PET? Circ CVI. ‘13;6(5):617-26
  • *Sleiman, et al. Loss of cellular inhibitor of apoptosis protein 2 reduces atherosclerosis in atherogenic apoE-/- C57BL/6 mice on high-fat diet. JAHA ‘13;2:e000259
  • *Ohira, et al. Low Agreement of 18F-FDG-PET and Cardiac Magnetic Resonance in Patients With Conduction Disease Due to Cardiac Sarcoidosis. Circ. ‘13;128:A15942 [abstract]
  • *Hall AB, et al. Effects of Short-Term CPAP on Myocardial Sympathetic Nerve Function and Energetics in HF and OSA. Circulation. ‘14. (in press)

Publications

Books Edited: (section)

  • Wahl R, Beanlands R. “Principles and Practices of PET and PET/CT”. Ed R. Wahl, Lippincott Williams & Wilkins 2008. (R. Beanlands, Cardiac Section Editor)

Chapters in Books:

  • Beanlands R, Wolpers, HG, Gropler R. “Determination of Myocardial Oxidative Metabolism Using C-11 Acetate PET”. Cardiac Positron Emission Tomography ed M. Schwaiger, Kluwer Publications 1996.
  • Beanlands R, Wolpers HG. “Applications of C-11 acetate PET in Dilated Cardiomyopathy” in Cardiac Positron Emission Tomography Ed. M. Schwaiger, Kluwer Publications 1996.
  • deKemp RA, Jones WF, Beanlands RS, Nahmias C. “Three-Dimensional Image Reconstruction” in Radiology and Nuclear Medicine: Computional Imaging and Vision. Ed P. Grangeat and JL Amans, Kluwer Academic Publishers 1996.
  • Ukkonen H, Beanlands RSB. “Oxidative Metabolism and Cardiac Efficiency” in Principles and Practices of Positron Emission Tomography, Ed. Wahl. 2002;83:351-367.
  • Beanlands RSB, Ruddy TD, Maddahi J. “Myocardial Viability” in Principles and Practices of Positron Emission Tomography, Ed. Wahl. 2002;8.2:334-350.
  • Tamaki N, Ruddy TD, de Kemp R, Beanlands RS. Myocardial Perfusion” in Principles and Practice of Positron Emission Tomography, Ed. Wahl. 2002;8.1:320-333.
  • R, Beanlands RS, Ruddy TD, deKemp RA. “3D Cardiac PET Imaging” in Research Advances in Nuclear Medicine, Ed. R. Mohan. Global Research Network 2002.
  • Yoshinaga K, Beanlands RSB, Heston T. AMyocardial Viability@ in Diagnostic Imaging: Nuclear Medicine, Ed. K. Morton; Amirsys: Salt Lake City UT 2007 3:22-25.
  • Yoshinaga K, Beanlands RSB, Heston T. AMyocardial Ischemia@ in Diagnostic Imaging: Nuclear Medicine. Ed. K. Heston; Amirsys: Salt Lake City UT 2007 3:16-21.
  • Yoshinaga K, Beanlands RSB, Heston T. AMyocardial Infarction@ in Diagnostic Imaging: Nuclear Medicine, Ed. K. Morton; Amirsys: Salt Lake City UT 2007 3:26-32.
  • Yoshinaga, K., Tamaki N., Ruddy, T., deKemp, R., Beanlands, R. “Myocardial Perfusion” in Principals and Practices of PET and PET/CT. 2nd edition. Ed. Wahl Philadelphia: Lippincott Williams and Wilkins 2008 Chapter 11.2.
  • Ukkonen H, Beanlands RSB. “Oxidative Metabolism and Cardiac” in Principles and Practices of PET and PET/CT, Ed. Wahl. Philadelphia: Lippincott Williams and Wilkins 2008 Chapter 11.4.
  • Beanlands R, Thorn S, DaSilva J, Ruddy T, Maddahi J. “Myocardial Viability”, in Principles and Practices of PET and PET/CT, Ed. Wahl. 2nd Edition Philadelphia: Lippincott Williams and Wilkins 2008 Chapter 11.2, p.565-588.
  • Wells RG, deKemp RA, Beanlands R, "Positron Emission Tomography (PET)” in Nuclear Cardiology Technical Applications by Ed. Gary Heller, Mann, Hendel. McGraw Hill 2009.
  • Ziadi MC, deKemp R, Yoshinaga K, Beanlands R. “Myocardial Perfusion and Flow with PET” in Clinical Nuclear Cardiology, Ed. Zaret and Beller. Mosby Elsevier 2009. Section 4, Chapter 19. Mosby 2010.
  • Dokainish H, Freidrich M, Ziadi MC, Beanlands R. “Imaging in the Patient with Heart Failure” in Heart Failure: A Companion to Braunwald’s Heart Disease. Ed. DL Mann 2009
  • Small G, Beanlands RSB.”Optimal Myocardial Viability Assessment.in Braunwalds Heart Disease” Ed E. Braunwald: 2011 (Invited)
  • Valdivia AC, Hadizad T, Mylonas I, Beanlands RS, DaSilva JN. “PET Radiopharmaceuticals for Cardiac Imaging in Humans” in Handbook of Nuclear Cardiology: SPECT and PET. Ed. G. Heller: 2012 (invited)

Monographs:
a) Wait Time Alliance for Timely Access to Health Care (CMA, CCS, CANM et al): It=s About Time! Achieving Benchmarks Best Practices in Wait Time Management. Final Report of the Wait Time Alliance for Timely Access to Health Care August 2005 (CCS Access to Care Group) and b) Universal Access, but When? Treating the Right Patient at the Right Time: Access to specialist consultation and non invasive testing, Access to cardiovascular nuclear imaging. (CCS Commentaries on Access to Care; O’Neill, Beanlands, et al). Beanlands R - CCS Subgroup Chair for Nuclear Cardiology and Member CANM Group. Oct 2006

b) Timely Access to Quality Acute Care and Diagnostics. Report from Theme Working Group 5 of the Canadian Heart Health Strategy. Glynn P, Ghali W, Alter D, Beanlands R. et al. February 2009.

Publications in Refereed Journals:

  • Beanlands R, Dawood F, Wen WH, McLaughlin PR, Butany J, D'Amati G, Liu PP. Are the kinetics of Technetium 99m-methoxy isobutyl isonitrile affected by cell metabolism and viability? Circulation l990;82(5):1802-1814.
  • Beanlands RSB, Schwaiger M: Positron emission tomography: Cardiac Applications. Current Opinion in Radiology 1991;3:817‑827.
  • Beanlands RSB, Muzik O, Hutchins G, Schwaiger M. Quantification of myocardial blood flow and flow reserve using PET. Coronary Artery Disease 1992;3(4):281-290.
  • Beanlands RSB, Muzik O, Mintun M, Mangner T, Lee K, Petry N, Hutchins GD, Schwaiger M: The kinetics of Copper-62 PTSM in the normal human heart. J Nucl Med 1992;33(5):684-690.
  • Beanlands RSB, Muzik O, Nguyen N, Petry N, Schwaiger M: The relationship between myocardial retention of technetium-99m retention and myocardial blood flow. J Am Coll Cardiol 1992;20(3):712-9.
  • Melon PG, Beanlands RS, DeGrado TR, Nguyen N, Petry N, Schwaiger M: Comparison of Tc-99m-sestamibi and thallium-201 retention characteristics in canine myocardium. J Am Coll Cardiol 1992;20:1277-83.
  • Muzik O, Beanlands R, Hutchins G, Mangner T, Nguyen N, Schwaiger M: Validation of N-13 ammonia injection technique for quantification of myocardial perfusion using dynamic PET in a canine model. JNM1993;34:83-91.
  • Muzik O, Beanlands R, Wolfe E, Hutchins GD, Schwaiger M: Automatized region definition procedure for regional quantification of myocardial perfusion using N-13 ammonia and PET. J Nucl Med 1993;34:336-344.
  • Laubenbacher C, Rothley J, Sitomer J, Beanlands R, Sawada S, Sutor R, Muller D, Schwaiger M. An automated analysis program for the evaluation of cardiac PET studies: initial results in the detection and localization of coronary artery disease using nitrogen-13-ammonia. J Nucl Med 1993;34:968-978.
  • Beanlands R, Bach D, Raylman R, Armstrong WF, Wilson V, Monteith M, Moore CK, Bates E, Schwaiger M: Acute effects of dobutamine on myocardial oxygen consumption and cardiac efficiency measured using C-11 acetate kinetics in patients with dilated cardiomyopathy. J Am Coll Cardiol 1993;22(5):1389-98.
  • Sawada S, Muzik O, Allman K, Beanlands R, Wolfe E, Gross M, Fig L, Schwaiger M. Positron emission tomography detects evidence of viability in rest technetium-99m sestamibi defects. J Am Coll Cardiol1994;23(1):92-98.
  • Beanlands R, Armstrong WF, Hicks R, Nicklas JM, Moore CK, Hutchins GD, Wolpers G, Schwaiger M: The effects of afterload reduction on myocardial C-11 acetate kinetics and noninvasively estimated mechanical efficiency in patients with dilated cardiomyopathy. J Nucl Cardiol 1994; 1(1):3-16.
  • Beanlands R, Shaikh NA, Wen WH, Dawood F, Ugnat AM, McLaughlin PR, Carere R, Liu PP: Alterations in fatty acid metabolism in adriamycin cardiomyopathy. J Mol Cell Cardiol 1994;26:109-119.
  • Beanlands R, Muzik O, Hutchins GD, Wolfe E, Allman K, Schwaiger M. Heterogeneity of regional N-13 labelled ammonia tracer distribution in the normal human heart: Comparison with rubidium-82 and copper-62- labelled PTSM. J Nucl Cardiol 1994;1(3):225-235.
  • Raylman RR, Hutchins GD, Beanlands R, Schwaiger M. Modelling of [C-11] acetate kinetics by simultaneously fitting data from multiple ROI's coupled by common parameters. JNM 1994;35(8):1286-1291.
  • Schwaiger M, Beanlands R, vom Dahl J. Metabolic tissue characterization in the failing heart by positron emission tomography. European Heart Journal (1994)15(Supplement D)14-19.
  • Fallen EL, Nahmias C, Scheffel A, Coates G, Beanlands RSB, Garnett ES. Redistribution of myocardial blood flow with topical nitroglycerin in patients with coronary artery disease. A PET Study. Circulation1995;91(5):1381-1388.
  • Beanlands RSB, Schwaiger M. Special article: Changes in myocardial oxygen consumption and efficiency with heart failure therapy measured using C-11 acetate PET. Can J Cardiol 1995;11(4):293-300.
  • Bach DS, Beanlands RSB, Schwaiger M, Armstrong WF. Heterogeneity of ventricular function and myocardial oxidative metabolism in nonischemic dilated cardiomyopathy. J Am Coll Cardiol 1995;(25):1258-1262.
  • Sawada S, Muzik O, Beanlands RS, Wolfe E, Manger TJ, Hutchins GD, Schwaiger M. Interobserver and Interstudy variability of myocardial blood flow and flow reserve measurements using Nitrogen-13 Positron Emission Tomography, J Nucl Cardiol 1995;2:413-422.
  • Beanlands R, Muzik O, Melon P, Sutor R, Sawada S, Muller D, Bondie D, Hutchins GD, Schwaiger M. Noninvasive quantification of regional myocardial flow reserve in stenosed and angiographically normal vessels of patients with coronary atherosclerosis. J Am Coll Cardiol 1995;26(6):1465-1475.
  • Tang ASL, Morton BC, Green MS, Beanlands RSB. Improvement of ventricular function after atrioventricular junction ablation in a patient with atrial flutter after Mustard’s operation. Can J Cardiol 1996;12(5):523-525.
  • Beanlands RSB, Ruddy TD, Harmsen E, deKemp R, Veinot J, Hartman NG. Myocardial kinetics of technetium-99m teboroxime in the presence of postischemic injury, necrosis and low flow reperfusion. JACC1996;28(2):487-494.
  • LeMay M, Labinaz M, Beanlands RSB, Laramee L, O’Brien ER, Marquis JF, Williams W, Al-Sadoon K, Davies RF, Kearns SA, Johansen H, Higginson LA. Usefulness of intracoronary stenting in acute myocardial infarction. Am J Cardiol 1996;78:148-152.
  • Beanlands R. Positron Emission Tomography in Cardiovascular Disease. Can J Cardiol 1996;12(10):875-883.
  • Beanlands R, Ruddy T*, Bielawski L*, Johansen H, Palser A, Masika M. Differentiation of myocardial ischemia and necrosis by technetium 99m glucaric acid kinetics. J Nucl Cardiol1997;4:274-282.
  • Beanlands RSB, deKemp R, Scheffel A, Nahmias C, Garnett ES, Coates G, Fallen E. Can N-13 ammonia kinetic modelling define myocardial viability independent of F-18 fluorodeoxyglucose? J Am Coll Cardiol1997;29(3):537-43.
  • Beanlands RSB, deKemp RA, Smith S, Johansen H, Ruddy TD. F-18-Fluorodeoxyglucose PET imaging alters clinical decision making in patients with impaired ventricular function. Am J Cardiol 1997;79:1092-1095.
  • Hendel RC, Kostuk W, Beanlands RSB, Chaudry F, Ascah KJ, Young H, Ruddy TD. Use of an arbutamine infusion for the detection of coronary artery disease: a comparison of Tc-99m sestamibi perfusion imaging and echocardiography. Am J Cardiol 1997;79(11):1518-1521.
  • Watson CC, Newport D, Casey MR, deKemp R, Beanlands RSB. Evaluation of simulation based scatter correction for 3D PET cardiac imaging. IEEE Trans Nucl Sci 1997;44:90-97.
  • Muzik O, Duvernoy C, Beanlands RSB, Sawada S, Dayanikli F, Wolfe ER, Schwaiger M. Assessment of the diagnostic performance of quantitative flow measurements in normals and patents with angiographically documented CAD using [N-13] ammonia and PET. J Am Coll Cardiol 1998;31:534-40.
  • LeMay MR, Labinaz M, Marquis J-F, O’Brien ER, Beanlands RS, Laramee LA, Williams WL., Davies RF, Kearns SA., Higginson LA.. Late clinical and angiographic follow-up after stenting in evolving and recent myocardial infarction. Am Heart J 1998;135:714-8.
  • Beanlands RSB, Hendry PJ, Masters RG, deKemp RA, Woodend K, Ruddy TD. Delay in revascularization is associated with increased mortality in patients with severe LV dysfunction and viable myocardium on FDG PET imaging. Circulation 1998; 98: II-51-II-56.
  • Fallen EL, Coates G, Nahmias C, Chirakal R, Beanlands R, Woodcock G, Thompson M, Kamath M. Recovery rates of regional sympathetic innervation and myocardial blood flow following an acute myocardial infarction. Am Heart J 1999;137(5):863-9.
  • Beanlands RSB, Labinaz M, Ruddy TD, Marquis JF, Williams W, Le May M, Laramee L, O'Brien ER, Aung M, Johansen H, Higginson LAJ. Establishing an approach for patients with recent coronary occlusion. Identification of viable myocardium. J Nucl Cardiol 1999;6(3):298-305.
  • Alvarez-Diez TM, deKemp R, Beanlands R, Vincent J. Manufacture of strontium-82/rubidiium-82 generators and quality control of rubidium-82 chlorided for myocardial perfusion imaging in patients using positron emission tomography. Applied Radiation and Isotopes 1999;50:1015-1023.
  • Ruddy TR, deKemp R, Beanlands R. Evaluation of myocardial perfusion and metabolism with positron emission tomography. CMAJ 1999; Vol. 161(9):1131.
  • *Abramson BL, Ruddy TD, deKemp RA, Laramee L, Marquis JF, Aubrey B, Aung M, Beanlands RS. Stress FDG PET as a new approach to the diagnosis of coronary disease in women. J Nucl Cardiol 2000; Vol. 7(3):205-212.
  • deKemp R, Ruddy T, Hewitt T, Dalipaj MM, Aung MT, Beanlands RSB. Detection of Serial Changes in Absolute Myocardial Perfusion with 82Rb PET. J Nucl Med 2000; Vol.41(8):1426-1435.
  • Beanlands R, Nahmias C, Gordon E, Coates G, deKemp R, Firnau G, Fallen E. The effects of beta-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with LV dysfunction. A double-blind, placebo-controlled PET study. Circulation 2000; Vol 102(17):2070-2075.
  • LeMay MR, Nichol G, Labinaz M, Marquis J-F, Laramee LA, O=Brien E, Beanlands RSB, Williams WL, Davies RF, Wells G, Higginson LA. Stents versus thrombolytics in acute myocardial infarction trial (STAT). J Am Coll Cardiol 2001; Vol. 37(4):985-991.
  • Sekar NS, Le May M, Ruddy T, deKemp R, Beanlands RS. Primary stent implantation for acute myocardial infarction achieves greater myocardial perfusion measured by Rb-82 PET than rt-PA. Am J Cardiol 2001; Vol 88;886-889.
  • *Vitale G, deKemp R, Ruddy TR, Beanlands R. Myocardial glucose utilization and the optimization of F-18-FDG PET imaging in patients with NIDDM, CAD and LV dysfunction. J Nucl Med 2001;42(12):1730-1736.
  • Beanlands RSB, Nichol G, deKemp R, Ruddy TD, Iwanochko M, Coates G, Freeman M, Nahmias C, Hendry P, Burns R, Lamy A, Mickleborough L, Kostuk W, Fallen E, and the PARR 1 Investigators. PET and Recovery Following Revascularization (PARR-1): The Importance of Scar and the Development of a Prediction Rule for the Degree of Recovery of LV Function. J Am Coll Cardiol 2002;40:1735-1743.
  • *Saab G, de Kemp RA, Ukkonen H, Ruddy TD, Germano G, Beanlands RSB. Gated 18- Fluorine Fluorodeoxyglucose Positron Emission Tomography: Determination of Global and Regional Left Ventricular Function and Myocardial Tissue Characterization. J Nucl Cardiol2003 May-Jun;10(3):297-303.
  • *Ukkonen H, Beanlands RSB, Burwash I, de Kemp RA, Nahmias C, Fallen E, Hill MRS, Tang ASL. The effect of cardiac resynchronization on myocardial efficiency and regional oxidative metabolism in patients with advanced congestive heart failure and conduction abnormality. Circulation 2003;107:28-31 (Ukkonen H supervised by Beanlands RSB)
  • Schelbert H, Beanlands RSB, Bengal FM, Di Carli M, Bax JJ. Practice Guidelines for Cardiac PET Imaging. J Nucl Cardiol 2003;10:557-71.
  • Beanlands RSB, Nichol G and the PARR Investigators. Design and Rationale of a Clinical Trial to Evaluate Outcome and Cost-Effectiveness of an FDG PET-Guided Approach to Management of Patients with Coronary Disease and Severe LV Dysfunction. (PARR Phase2). Controlled Clinical Trials 2003;24:776-794.
  • LeMay M, Davies RF, Labinaz M, Sherrard H, Marquis J-F, Laramee LA, O=Brien ER, Williams WL, Beanlands RS, Nichol G, Higginson LA.. Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction. Cost Analysis of the Canadian STAT Study. Circulation 2003;108:2624-30.
  • *Parkash R, de Kemp RA, Ruddy TD, Kitsikis A, Hart R, Beauschene L, Williams K , Davies RA, Labinaz M, Beanlands RSB. Potential utility of perfusion quantification using rubidium-82 PET in patients with three-vessel coronary artery disease measured using rubidium-82 PET. J Nucl Cardiol 2004; 11(4):440-449.
  • Epstein N, Benelfassi A, Beanlands R, deKemp R. A rubidium-82 infusion system for quantitative perfusion imaging with 3D PET. Applied Radiation and Isotopes 2004;60:921-927.
  • Wassenaar RW, Beanlands RSB, deKemp RA. Phantom Studies Investigating Extravascular Density Imaging for Partial Volume Correction of 3-D PET 18-FDG Studies. IEEE Transactions on Nuclear Science 2004;Vol 51 No1:68-71.
  • Westerman E, Aubrey B, Gauthier D, Aung M, Beanlands RSB, Ruddy TD, Davies RA, deKemp, RA,Woodend K. Positron Emission Tomography: A Study of PET Test-Related Anxiety. Journal of Cardiovascular Nursing 2004;14(2):42-8.
  • Yoshinaga K, Katoh C, Beanlands RSB, Noriyasu K, Komuro K, Yamada S, Kuge Y, Morita K, Kitabatake A, Tamaki N. Reduced oxidative metabolic response in dysfunctional myocardium with preserved glucose metabolism but impaired contractile reserve. J Nucl Med2004;45:1885-1891.
  • *Ananthasubramaniam K, Chow BJW, deKemp RA, Davies RA, Ruddy TD,Beanlands RSB. Does Electrocardiographic Q Wave Burden Predict the Extent of Scar or Hibernating Myocardium as Quantified by Positron Emission Tomography? Revisions Can J Cardiol2005;21(1):51-56.
  • *Yoshinaga K, Chow B, deKemp R, Thorn S, Davies R, Ruddy T, DaSilva J, Beanlands R. Application of Cardiac Molecular Imaging Using PET in Evaluation of Drug and Therapeutics for Cardiovascular Disorders. Current Pharmaceutical Design 2005;11:903-932.
  • *Mielniczuk L., deKemp R, Dennie C, Yoshinaga K, Burwash I, Benard F, Haddad H, Beanlands DS, Beanlands RSB. FDG PET in the Diagnosis and Management of a Patient with Aortitis with Pulmonary Involvement. Circulation 2005;111(22):e375-6.
  • *Chow BJW, Ananthasubramiam K, deKemp RA, Dalipaj M, Beanlands RSB, Ruddy TD. Comparison of Treadmill Exercise Versus Dipyridamole Stress withMyocardial Perfusion Imaging Using 82Rb Positron Emission Tomography. J Am Coll Cardiol 2005;45:1227-34. (R. Beanlands – co-supervisor)
  • *Ling M, Ukkonen H, Ruddy T, de Kemp R, Duchesne L, Higginson L, Williams KP, McPherson R, Beanlands R. Early Improvement in Myocardial Perfusion and Flow- Mediated Dilatation with Simvastatin in Patients with Coronary Artery Disease. Am Heart J 2005;149(6):1137.
  • *Chow BJW, Wong JW, Yoshinaga K, Ruddy TD, deKemp RA, DaSilva J, Beanlands RS. Prognostic Significance of Dipyridamole Induced ST Depression in Patients with Normal Rb-82 PET Myocardial Perfusion Imaging. J Nucl Med. 2005; 46:1095- 1101.
  • LeMay MR, Wells GA, Labinaz M, Davies RF, Turek M, Leddy D, Maloney J, McKibbin T, Quinn , Beanlands RS, Glover C, Marquis JF, O’Brien ER, Williams W, Higginson LA. Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI Study). J Am Coll Cardiol 2005;46:417-424.
  • *Chow B, Beanlands R, Lee A, DaSilva J, deKemp R, Alkahatani A, Ruddy T. Treadmill Exercise Produces Larger Perfusion Defects than Dipyridamole Stress N-13 Ammonia Positron Emission Tomography. J Am Coll Cardiol 2006;47(2):411-16. (R. Beanlands – co-supervisor).
  • Mahmoud S, Beanlands RS, deKemp RA, Chan KL, Beauchesne LM. Native anomalous left coronary artery from the pulmonary artery in an adult: Evidence of impaired coronary flow reserve by rubidium-82 positron emission tomography quantification. Can J Cardiol 2006 October;22(12):1069-1070.
  • Blais C, Burwash IG, Mundigler G, Dumesnil JG, Loho N, Rader F, Baumgartner H, Beanlands RS, Kadem L, Garcia D, Chayer B, Durand L-G, Pibarot P. The Projected Valve Area at Normal Flow Rate Improves the Assessment of Stenosis Severity in Patients with Low Flow, Low Gradient Aortic Stenosis. The Multicenter TOPAS (Truly Or Pseudo Severe Aortic Stenosis) Study. Circulation2006;113;711-721.
  • Lourenco CM, Kenk M, Beanlands RS, DaSilva JN. Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart. Life Sciences 2006; 79:356-364.
  • *Yoshinaga K, Beanlands RS, deKemp RA, Lortie M, Morin J, Aung M, McKelvie R, Davies RF. Effect of exercise training on myocardial blood flow in patients with stable coronary artery disease. Am Heart J 2006 June;151(6):1324-1328. (K. Yoshinaga supervised by R Beanlands).
  • *Yoshinaga K, Chow BJ, Williams K, Chen L, deKemp RA, Garrard L, Lok-Tin SA, Aung M, Davies RA, Ruddy TD, Beanlands RS. What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? J Am Coll Cardiol 2006 September 5;48(5):1029-1039.
  • *Yoshinaga K, Beanlands RS. Myocardial Viability Assessment Using Single Photon Emission Tomography and Positron Emission Tomography. Japanese Journal of Clinical Radiology 2006; 51: 1043-1052.
  • Gulenchyn K, McEwan AJB, Freeman M, Kiess M, O’Neill BJ, Beanlands RS. Treating the Right Patient at the Right Time. Access to Cardiovascular Nuclear Imaging. Can J Cardiol 2006;22(10):827-833.
  • Knudtson ML, Beanlands RS, Brophy J, Higginson L, Munt B, Rottgert J on behalf of the Canadian Cardiovascular Society Access to Care Working Group. Treating the Right Patient at the Right Time: Access to Specialist Consultation and Non-Invasive Testing. Can J Cardiol 2006; 22(10):819-824.
  • *Thompson K, Saab G, Birnie D, Chow BJ, Ukkonen H, Ananthasubramaniam K, deKemp RA, Garrard L, Ruddy TD, Dasilva JN, Beanlands RS. Is septal glucose metabolism altered in patients with left bundle branch block and ischemic cardiomyopathy? J Nucl Med 2006 November;47(11):1763-1768.
  • Machac J, Bacharach SL, Bateman TM, Bax JJ, Beanlands R, Bengel F, Bergmann SR, Brunken RC, Case J, Delbeke D, DiCarli MF, Garcia EV, Goldstein RA, Gropler RJ, Travin M, Patterson R, Schelbert HR. Positron emission tomography myocardial perfusion and glucose metabolism imaging. J Nucl Cardiol 2006 November;13(6):e121-e151.
  • Bax JJ, Beanlands RS, Klocke FJ, Knuuti J, Lammertsma AA, Schaefers MA, Schelbert HR, Von Schulthess GK, Shaw LJ, Yang GZ, Camici PG. Diagnostic and clinical perspectives of fusion imaging in cardiology: is the total greater than the sum of its parts? Heart. 2007 Jan;93(1):16-22.
  • *Yoshinaga K, Burwash IG, Leech JA, Haddad H, Johnson CB, deKemp RA, Garrard L, Chen L, K, DaSilva JN, Beanlands RS. The effects of continuous positive airway pressure on myocardial energetics in patients with heart failure and obstructive sleep apnea. J Am Coll Cardiol. 2007 Jan 30;49(4):450-8.
  • Beanlands R, Dick A, Chow B, et al. CCS; CAR; CANM;CNCS; and CanSCMR Position Statement on Advanced Noninvasive Cardiac Imaging using Positron Emission Tomography, Magnetic Resonance Imaging and Multi-Detector Computed Tomographic Angiography in the Diagnosis and Evaluation of Ischemic Heart Disease. Can J Cardiol. 2007 Feb;23(2):107-19.
  • Klein R, Adler A, Beanlands RS, deKemp RA. Precision Control of Eluted Activity from a Sr/Rb Generator for Cardiac Perfusion Imaging with 3D PET. Phys Med Biol2007;52:659-673.
  • Kenk M, Greene M, deKemp RA, Lortie M, Thorn S, Beanlands RS, DaSilva JN. In vivo selective binding of (R)‑[11C]rolipram to phosphodiesterase‑4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. 2007Nuc Med & Bio34:71-77.
  • Bax JJ, Abbott BG, Beanlands RS, Bengel F, Berman DS, Garcia EV, Hendel RC, Mieres JH, Shaw LJ, Wackers FJ. Highlights of the 2006 Scientific sessions of the American Society of Nuclear Cardiology: Montreal, Canada, September 7 to 10, 2006.J Am Coll Cardiol. 2007 Jan 30;49(4):502-8.
  • Chow B, Dennie C, Hoffmann U, deKemp R, Ruddy T, Beanlands R. Comparison of Computed Tomographic Angiography versus Rubidium-82 Positron Emission Tomography for the Detection of Patients with Anatomical Coronary Artery Disease. Can J Cardiol. 2007. Aug;23(10):801-7.
  • Bergler-Klein J, Mundigler G, Pibarot P, Burwash I, Dumesnil JG, Blais C, Beanlands R, Hachicha Z, Mohty-Eichahidi D, Loho N, Rader F, Baumgartner H. B-Type natriuretic peptide in low-flow, low-gradient aortic stenosis: Relationship to hemodynamics and clinical outcome.Results from the multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) Study. Circulation.2007 Jun 5;115(22):2848-55
  • deKemp R, Yoshinaga K, Beanlands R. Will 3D PET enable routine quantification of myocardial blood flow? J.Nucl.Cardiol. 2007. May-June 14(3):380-397
  • Hessian R, Beanlands R. Angina Pectoris: Has the Cornerstone of Symptomatic Coronary Disease Been Moved? Can J Cardiol 2007. June;23(8) 648-50
  • Beanlands R, Roberts R. Positron Molecular Imaging, an In Vivo glimpse of the genome. J Mol Cell Card 2007 July 43;(1):11-14
  • Beanlands RSB, Nichol G, Huszti E, Humen D, Racine N, Freeman M, Gulenchyn KY, Garrard L, deKemp R, Gao A, Ruddy TD, Benard F, Lamy A, Iwanochko RM and the PARR2 Investigators. F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients with Severe Left Ventricular Dysfunction and Suspected Coronary Disease. A Randomized Controlled rial (PARR-2). J Am Coll Cardiol ; 2007 Nov 13;50(20):2002-12
  • *Thackery J, Beanlands R, and DaSilva J. Inverse Correlation of Specific [11C] meta-Hydroxyephedrine Retention to Norepinephrine Levels in Heart, Lung, Pancreas and Brown Adipose Tissue. J Nucl Med. 2007 Oct;48(10):1733-40 (R. Beanlands co-supervisor)
  • Lortie M, Beanlands RSB, Yoshinaga K, Klein R, DaSilva J, deKemp R. Quantification of Myocardial Blood Flow with 82Rb Dynamic PET Imaging. Eur J Nucl Med Molec Imaging. 2007 Nov;34(11):1765-74.
  • Ruel M, Beanlands R, Lortie M, Chan V, deKemp R, Suuronen E, Rubens FD, DaSilva J, Sellke FW, Stewart DJ, Mesana TG; Concomitant Treatment with Oral L-Arginine Improves the Efficacy of Surgical Angiogenesis in Patients with Severe Diffuse Coronary Artery Disease: The Endothelial Modulation in Angiogenic Therapy (EMAT) Randomized Controlled Trial. J Thorac Cardiovasc Surg 2008 April; 135 (4): 762-70
  • Kenk M, Greene M, Lortie M, Dekemp RA, Beanlands RS, Dasilva JN. Use of a column-switching high-performance liquid chromatography method to assess the presence of specific binding of (R)- and (S)-[(11)C]rolipram and their labeled metabolites to the phosphodiesterase-4 enzyme in rat plasma and tissues. Nucl Med Biol. 2008 May;35(4):515-21.
  • Anselm AH, Gauthier N, Beanlands RS, Haddad H. Sleep apnea in chronic heart failure. Curr Opin Cardiol. 2008 Mar;23(2):121-6.
  • Johnson CB, Beanlands RS, Yoshinaga K, Haddad H, Leech J, deKemp R, Burwash IG. Acute and Chronic Effects of Continuous Positive Airway Pressure Therapy on Left Ventricular Systolic and Diastolic Fuction in Patients with Obstructive Sleep Apnea and Congestive Heart Failure. Can J Cardiol. 2008 Sep;24(9):697-704.
  • Clavel MA, Fuchs C, Burwash IG, Mudigler G, Dumesnil JG, Baumgartner H, Bergler-Klein J, Beanlands RS, Mathieu P, Magne J, Pibarot P; Predictors of Outcomes in Low Flow, Low Gradient Aortic Stenosis: Results of the Multicenter TOPAS Study. Circulation. 2008 Sep 30;118(14 Suppl):S234-42.
  • Mussivand T, Alshaer H, Haddad H, Beanlands DC, Beanlands RS, Chan KL, Higginson L, Leenan F, Ruddy TD, Mesena T, Silver MA. Thermal Therapy: A Viable Adjunct in the Treatment of Heart Failure? Congest Heart Fail. 2008 Jul-Aug;14(4):180-6
  • Burwash I. G., Lortie M, Pibarot P, deKemp R, Graf S, Mundigler G, Khorsand A, Blais C, Baumgartner H, Dumesnil J. G, Hachicha Z, DaSilva J, and Beanlands R. Myocardial Blood Flow in Patients with Low Flow, Low Gradient Aortic Stenosis: Differences Between True and Pseudo-Severe Aortic Stenosis. Results from the Multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) Study. Heart. 2008 Dec; 94(12):1627-33.
  • *Ukkonen H, Burwash I, deKemp RA, Haddad H, Dafoe W, Yoshinaga K, Davies RA, DaSilva JN, Beanlands RS. Is Ventilatory Efficiency (VE/VCO2 Slope) with Exercise Associated with Right Ventricular Oxidative Metabolism in Patients with Congestive Heart Failure? Eur J Heart Fail. 2008 Nov;10(11):1117-22
  • *Zhang, Y., Ruel, M., Beanlands, R.S., deKemp R.A., Suuronen, E.J., and DaSilva, J.N., Tracking stem cell therapy in the myocardium: applications of positron emission tomography. Current Pharmaceutical Design. 2008;14(36):3835-53
  • *Zhang Y, Thorn S; DaSilva J, Lamoureux M, deKemp R, Beanlands R, Ruel M, Suuronen E. Collagen-based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells: Development and Demonstration by ex vivo Radionuclide Cell Labeling and in vivo Tracking with Positron Emission Tomography. Circulation: Cardiovascular Imaging 2008;1:197-204
  • *Chow BJ, Abraham A, Wells GA, Chen L, Ruddy TD, Yam Y, Govas N, Dennie C, Beanlands RS. Diagnostic Accuracy and Impact of Computed Tomographic Coronary Angiography on Utilization of Invasive Coronary Angiography. Circulation: Cardiovascular Imaging. 2009;2:16-23
  • *Lalonde L, Ziadi MC, Beanlands RS. Cardiac Positron Emission Tomography: Current Clinical Practice. Cardiology Clinics 2009 May;27(2):237-55
  • *Greene M, Thackeray J, Kenk M, Thorn S, Harper ME, Beanlands RS, DaSilva JN. Reduced in Vivo Phosphodiesterase-4 Response to Norepinephrine Challenge in Diet-Induced Obese Rats. Can J Physiol and Pharm 2009 Mar;87(3):196-202
  • *Ziadi M, deKemp R, Beanlands R. Quantification of Myocardial Perfusion: What Will It Take to Make It Prime time? Current Cardiovascular Imaging Reports. 2009, 2:238-249
  • *Ukkonen H, Yoshinaga K, DaSilva JN, Beanlands RS, Knuuti J. Cardiovascular drug development using radiopharmaceuticals. Curr Pharm Des. 2009;15(9):935-42
  • V Dilsizian, S Bacharach, R Beanlands, S Bergmann, D Delbeke, R Gropler, J Knuuti, H Schelbert, N Tamaki, M Travin. PET myocardial perfusion and metabolism clinical imaging. J Nucl Card 2009 Aug. 16(4):651 (ASNC Imaging Guidelines for Nuclear Cardiology Procedures) http://www.asnc.org/imageuploads/ImagingGuidelinesPETJuly2009.pdf
  • *Beanlands R, Ziadi MC, Williams K. Quantification of Myocardial Flow Reserve Using Pet Imaging: The Journey to Clinical Use. J Am Coll Cardiol 2009 Jul 7;54(2):157-9
  • *Chow B, Al-Shammeri OM, Beanlands R, Chen L, deKemp RA, DaSilva J, Ruddy T. Prognostic Value of Treadmill Exercise and Dobutamine Stress Positron Emission Tomography Can J Cardiol. 2009 Jul;25(7):e220-4.
  • *Hadizad T, Kirkpatrick S, Mason S, Burns K, Beanlands R, DaSilva JN. Novel O-[11C]Methylated Derivatives of Candesartan as Angiotensin II AT1 Receptor Imaging Ligands: Radiosynthesis and Ex Vivo Evaluation in rats". Bioorg Med Chem 2009. 17(23):7971-7.
  • *Birnie D, deKemp RA, Ruddy T, Tang AS, Green M, Lemery R, Gollob M, Guo A, Williams K, Wassenar R, Lalonde M, Thomson K, DaSilva J, Beanlands R. Effect of Lateral Wall Scar on Reverse Remodeling with Cardiac Resynchronization Therapy. Heart Rhythm 2009. 6(12):1721-6
  • *D’Egidio G, Nichol G, Williams K, Guo A, Garrard L, deKemp R, Ruddy TD, DaSilva J, Humen D, Gulenchyn K, Freeman M, Racine N, Benard F, Hendry P, Beanlands R; Identification of High Risk Patients with Ischemic Cardiomyopathy: Increasing Benefit from Revascularization is Associated with Increasing Amounts of Hibernating Myocardium. A substudy of the PARR 2 trial. JACC. Cardiovascular imaging. JACC Cardiovasc Imaging. 2009 Sep;2(9):1060-8 (Young Author Awardee)
  • MacHaalany J, Yam Y, Ruddy T, Abraham A, Chen L, Beanlands RS, Chow B. Potential Clinical and Economic Consequences of Non-Cardiac Incidental Findings on Cardiac Computed Tomography. Journal of the American College of Cardiology. J Am Coll Cardiol. 2009 Oct 13;54(16):1533-41.
  • *Ha A, Renaud J, deKemp RA, Thorn S, DaSilva J, Garrard L, Yoshinaga K, Abraham A, Greene M, Beanlands RS, Gollob M. In Vivo Assessment of Myocardial Glucose Uptake by Positron-Emission Tomography in Adults with the PRKAG2 Cardiac Syndrome: A Pilot Study Evaluating the Utility of PET Imaging in Elucidating Mechanisms of Disease. Circulation. Cardiovascular imaging. Circulation: Cardiovasc Imaging. 2009 Nov;2(6):485-91. (R. Beanlands Co-Supervisor)
  • Valdivia A, Mason S, Collins J, Buckley K, Beanlands R, DaSilva J. Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a potential PET radiotracer for Rho-kinases (ROCKs). Applied Radiation and Isotopes 2009 68(2);p325-328.
  • Hachamovitch R, Johnson JR, Hlatky MA, Cantagallo L, Johnson BH, Coughlan M, Hainer J, Gierbolini J, Di Carli MF; SPARC Investigators. The study of myocardial perfusion and coronary anatomy imaging roles in CAD (SPARC): design, rationale, and baseline patient characteristics of a prospective, multicenter observational registry comparing PET, SPECT, and CTA for resource utilization and clinical outcomes. J Nucl Cardiol. 2009 Nov-Dec;16(6):935-48.
  • *Lekx K, deKemp RA, Beanlands RS, Wisenberg G, Wells RG, Stodilka R, Lortie M, Klein R, Zabel P, Kovacs M, Sykes J, Prato F. Quantification of Regional Myocardial Blood Floow in a Canine Model of Stunned and Infarcted Myocardium: Comparison of 82Rb PET with Microspheres. Nucl Med Commun. 2010 Jan;31(1):67-74. . (R. Beanlands Co-Supervisor)
  • *Lekx K, deKemp RA, Beanlands RS, Wisenberg G, Wells RG, Stodilka R, Lortie M, Klein R, Zabel P, Kovacs M, Sykes J, Prato P. 3D vs. 2D dynamic 82Rb myocardial blood flow imaging in a canine model of stunned and infarcted myocardium. Nucl Med Commun. 2010 Jan;31(1):75-81. . (R. Beanlands Co-Supervisor)
  • *Abraham A, Nichol G, Williams K, Garrard L, Guo A, deKemp RA, Davies RA, Duchesne L, Haddad H, Ruddy TD, Chow B, DaSilva J, Hendry P, Masters R, Higginson L, Beanlands RS. Ottawa-FIVE: FDG In Viability Evaluation at an Experienced Center with Ready Access to FDG and Integration with Management Teams. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. J Nucl Med. 2010 Apr;51(4):567-74.
  • *Nery P, D’Mello N, Beanlands R. Screening Patients for Primary Prophylaxis ICDs: Insights into Current Practices. Can J Cardiol 2010 Mar;26(3):e125-7.
  • Chow B, Wells G, Chen L, Yam Y, Galiwango P, Abraham A, Beanlands R, Dennie C, Sheth T, Ruddy T. Prognostic Value of 64-slice Cardiac CT: Severity of Coronary Artery Disease, Coronary Atherosclerosis and Left Ventricular Ejection Fraction. Journal of the American College of Cardiology. J Am Coll Cardiol. 2010 Mar 9;55(10):1017-28.
  • Clavel MA, Burwash I, Mundigler G, Dumesnil J, Baumgartner H, Bergler-Klein J, Sénéchal M, MathieuP, Couture C, Beanlands R, Pibarot P. Validation of Conventional and Simplified Methods to Calculate Projected Valve Area at Normal Flow Rate in Patients with Low Flow, Low Gradient Aortic Stenosis. The Multicenter TOPAS (True or Pseudo Severe Aortic Stenosis) Study. J Am Soc Echocardogr 2010 Apr;23(4):380-6.
  • *Kenk M, Thackeray J, Thorn S, Dhami K, Chow B, Ascah K, DaSilva J, Beanlands, R. Alterations of pre- and post-synaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity. J Nucl Cardiol 2010 Apr;17(2):254-63.
  • Abraham A, Kass M, Ruddy TD, deKemp RA, Lee AK, Ling MC, Ha A, Beanlands RS, Chow BJ. Right and left ventricular uptake with Rb-82 PET myocardial perfusion imaging: markers of left main or 3 vessel disease. J Nucl Cardiol. 2010 Jan-Feb;17(1):52-60.
  • Chow B, Abunassar J, Ascah K, deKemp R, Dasilva J, Mesana T, Beanlands R, Ruddy T. The Effects of Mitral Valve Surgery on Myocardial Energetics in Patients with Severe Mitral Regurgitation. Circulation: Cardiovascular Imaging 2010. 3:308-313
  • Valdivia AC, Mason S, Collins J, Buckley KR, Coletta P, Beanlands RS, Dasilva JN. Radiosynthesis of N-[(11)C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs). Appl Radiat Isot. 2010 Feb;68(2):325-8.
  • Klein R, Renaud J, Ziadi M, Thorn S, Adler A, Beanlands R, deKemp R. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using Rubdium-82 PET and a highly automated analysis program. J Nucl Cardiol 2010 Aug;17(4):600-16.
  • Crawford SA, Costford SR, Aguer C, Thomas SC, Dekemp RA, Dasilva JN, Lafontaine D, Kendall M, Dent R, Beanlands RS, McPherson R, Harper ME. Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes. Diabetologia. 2010;53(9):1986-97.
  • Gropler R, Beanlands RSB, Dilsizian V, Lewandowski ED, Villanueva FS, Ziadi MC. Imaging Myocardial Metabolic Remodeling. J Nucl Med 2010 May;51 Suppl 1:88S-101S. Review.
  • Chow BJW, Joseph P, Yam Y, Kass M, Chen L, Beanlands RS, Ruddy TD. Usefulness of Computed Tomographic Coronary Angiography in Patients With Acute Chest Pain With and Without High-Risk Features. Am J Cardiol. 2010 Aug 15;106(4):463-469.
  • Klein R, Beanlands RS, deKemp RA. Quantification of myocardial blood flow and flow reserve: Technical aspects. J Nucl Cardiol. 2010 Aug;17(4):555-70.
  • *Beanlands RS, Youssef G. Diagnosis and prognosis of coronary artery disease: PET is superior to SPECT: Pro. J Nucl Cardiol. 2010 Aug;17(4):683-95.
  • *Ziadi MC, Beanlands RS. The clinical utility of assessing myocardial blood flow using positron emission tomography. J Nucl Cardiol. 2010 Aug;17(4):571-81.
  • Wells RG, Ruddy TD, deKemp RA, DaSilva JN, Beanlands RS. Single-Phase CT Aligned to Gated PET for Respiratory Motion Correction in Cardiac PET/CT. J Nucl Med 2010 Aug;51(8):1182-90.
  • Klein R., Beanlands RS, Wassenaar R. W., Thorn S., Lamoureux M., DaSilva J. N., Adler A., deKemp R. A., Kinetic model-based factor analysis of dynamic sequences for 82-rubidium cardiac positron emission tomography. Med Phys. 2010;37(8):3995-4010.
  • Yoshinaga K, Osamu M, Chietsugu K, Masanao N, deKemp R, Klein R, Beanlands R, Nagara T. Quantitative Analysis of Coronary Endothelial Function with Generator Produced Rubidium-82 PET - Comparison with Oxygen 15-Labeled Water PET. Eur J Nucl Med 2010;37(12):2233-41.
  • *Ghosh N, Rinoldi O, Beanlands R, Camici P. Assessment of Myocardial Ischemia and Viability: Role of PET. Eur Heart J 2010;31(24):2984-95. (R. Beanlands – supervisor)
  • Mielniczuk L, Ziadi MC, deKemp RA, DaSilva JN, Tang AT, Davies RA, Haddad H, Guo A, Aung M, Beanlands R, Birnie D. The relationship between right ventricular function and increased right ventricular [18F] fluorodeoxyglucose accumulation in patients with heart failure. Circulation: Cardiovascular Imaging 2011;4(1):59-66
  • Hackam DG, Shojania KG, Spence JD, Alter DA, Beanlands RS, Dresser GK, Goela A, Davies AH, Badano LP, Poldermans D, Boersma E, Njike VY. Influence of Noninvasive Cardiovascular Imaging in Primary Prevention: Systematic Review and Meta-analysis of Randomized Trials. Arch Intern Med. 2011;171(11):977-82.
  • Paterson I, OMeara E, Chow B, Ukkonen H, Beanlands RS. Recent Advances in Cardiac Imaging for Patients with Heart Failure. Curr Opin Cardiol. 2011;26(2):132-43.
  • *Thomas AJ, DaSilva JN, Lortie M, Renaud JM, Kenk M, Beanlands RS, deKemp RA. PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart. J Nucl Med. 2011 Feb;52(2):263-9. (R. Beanlands – co-supervisor)
  • *Mylonas I, Beanlands RS. Radionuclide Imaging of Viable Myocardium: Is it Underutilized? Curr Cardiovasc Imaging Rep. 2011 Jun;4(3):251-261.
  • Mailloux RJ, Dumouchel T, Aguer C, Dekemp R, Beanlands R, Harper ME. Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration. Biochem J. 2011;437(2):301-311.
  • Sadeghi, M. M., Schwartz, R. G., Beanlands, R. S., Al-Mallah, M. H., Bengel, F. M., Borges-Neto, S., et al. Cardiovascular nuclear imaging: Balancing proven clinical value and potential radiation risk. J Nucl Med 2011;52(7):1162-1164.
  • *Ziadi MC, deKemp RA, Williams K, Guo A, Chow BJW, Renaud JM, Ruddy TD, Sarveswaran N, Tee R, Beanlands RSB. Impaired Myocardial Flow Reserve on Rubidium-82 Positron Emission Tomography Imaging Predicts Adverse Outcomes In Patients Assessed for Myocardial Ischemia. J Am Coll Cardiol. 2011;58(7):740-8.
  • Dekemp RA, Trottier M, Beanlands RS. Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography. J Nucl Cardiol. 2011;18(4):541-3.
  • *Anselm D, Anselm A, Renaud J, Atkins H, deKemp R, Burwash I, Williams K, Guo A, Kelly C, DaSilva J, Beanlands R, Glover C. Altered myocardial glucose utilization and the reverse mismatch pattern on F-18-FDG PET during the sub-acute phase following reperfusion of acute anterior myocardial infarction. J Nucl Cardiol. 2011;18(4):657-67. (R. Beanlands – co-supervisor)
  • Kenk M, Thomas A, Lortie M, deKemp R, Beanlands RS, DaSilva JN. PET Measurements of cAMP-Mediated Phosphodiesterase-4 with (R)-[11C]Rolipram. Curr Radiopharm. 2011;4(1):44-58.
  • *Thackeray JT, Parsa-Nezhad M, Kenk M, Thorn SL, Kolajova M, Beanlands RS, DaSilva JN. Reduced CGP12177 binding to cardiac beta-adrenoceptors in hyperglycemic high fat diet-fed, streptozotocin-induced diabetic rats. Nucl Med Biol. 2011;38(7):1059-66. (R. Beanlands – co-supervisor)
  • *Thackeray JT, Radziuk J, Harper ME, Suuronen EJ, Ascah KJ, Beanlands RS, Dasilva JN. Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia. Cardiovasc Diabetol. 2011;10:75. (R. Beanlands – co-supervisor)
  • *Youssef G, Beanlands R, Birnie D, Nery P. Cardiac Sarcoidosis: Applications of Imaging in Diagnosis and Directing Therapy. Heart J. 2011;97(24):2078-87. (R. Beanlands – co-supervisor)
  • Birnie D, de Kemp RA, Tang AS, Ruddy TD, Gollob MH, Guo A, Williams K, Thomson K, Dasilva JN, Beanlands RS. Reduced septal glucose metabolism predicts response to cardiac resynchronization therapy. J Nucl Cardiol. 2012;19(1):73-83.
  • Tandon V, Hall D, Yam Y, Al-Shehri H, Chen L, Tandon K, Beanlands RS, Wells GA, Ruddy TD, Chow BJ. Rates of downstream invasive coronary angiography and revascularization: computed tomographic coronary angiography vs. Tc-99m single photon emission computed tomography. Eur Heart J. 2012;33(6):776-82.
  • Youssef G, Leung E, Mylonas I, Nery P, Williams K, Wisenberg G, Gulenchyn KY, deKemp RA, DaSilva J, Birnie D, Wells G, Beanlands RSB. The Use of FDG-18 PET Imaging in the Diagnosis of Cardiac Sarcoidosis, a Systematic Review and Meta-analysis Including the Ontario Experience. J Nucl Med. 2012;53(2):241-8.
  • *Ziadi MC, deKemp RA, Williams K, Guo A, Renaud JM, Chow BJW, Klein R, Ruddy TD, Aung M, Garrard L, Beanlands RSB. Does Quantification of Myocardial Flow Reserve Using Rubidium-82 Positron Emission Tomography Facilitate Detection of Multivessel Coronary Artery Disease? J Nucl Cardiol. 2012 Mar 14. [Epub ahead of print]
  • Perrin MJ, Green MS, Redpath CJ, Nery PB, Keren A, Beanlands RS, Birnie DH. Greater response to cardiac resynchronization therapy in patients with true complete left bundle branch block: a PREDICT substudy. Europace. 2012;14(5):690-5.
  • Hadizad T, Collins J, Antoun R, Beanlands R, DaSilva J. [11C]methyl-losartan as a Potential Ligand for PET Imaging Angiotensin II AT1 Receptors. J. Label. Comp. Radiopharm. 2011;54: 754-757.
  • Hachamovitch R, Nutter B, Hlatky MA, Shaw LJ, Ridner ML, Dorbala S, Beanlands RSB, Chow BJW, Branscomb E, Chareonthaitawee P, Weigold WG, Voros S, Abbara S, Yasuda T, Jacobs JE, Lesser J, Berman DS, Thomson L, Raman S, Heller GV, Schussheim A, Brunken R,Williams KA, Farkas S, Delbeke D, Schoepf UJ, Reichek N, Rabinowitz S, Sigman SR, Patterson R, Corn CR, White R,Kazerooni E, Corbett J, Bokhari S, Machac J, Guarneri M, Borges-Neto B, Millstine JW, Caldwell J,Arrighi J, Hoffmann U, Budoff M, Lima J, Johnson JR, Johnson B, Gaber M, Williams JA, Foster C, Hainer J, Di Carli MF, for the SPARC study Investigators. Patient Management after Non-invasive Cardiac Imaging: Results From the Study of Myocardial Perfusion and Coronary Anatomy Imaging Roles in Coronary Artery Disease (SPARC). J Am Coll Cardiol. 2012;59(5):462-74.
  • Zhang Y, Dasilva JN, Hadizad T, Thorn S, Kuraitis D, Renaud JM, Ahmadi A, Kordos M, Dekemp RA, Beanlands RS, Suuronen EJ, Ruel M. (18)F-FDG Cell Labeling may Underestimate Transplanted Cell Homing: More Accurate, Efficient and Stable Cell Labeling with Hexadecyl-4-[(18)F]fluorobenzoate for In Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission Tomography. Cell Transplant. 2012 Mar 28. [Epub ahead of print]
  • Mielniczuk L, Beanlands R, Imaging-Guided Selection of Patients with Ischemic Heart Failure for High Risk Revascularization Improves Identification of those with the Highest Clinical Benefit. Circulation Cardiovascular Imaging 2012; 5(2):262-70.
  • *Ziadi MC, Dekemp RA, Williams K, Guo A, Renaud JM, Chow BJ, Klein R, Ruddy TD, Aung M, Garrard L, Beanlands RS. Usefulness of Beta-Blocker Therapy and Outcomes in Patients With Pulmonary Arterial Hypertension. Am J Cardiol. 2012 Feb 29. [Epub ahead of print]
  • Mitoff PR, Beauchesne L, Dick AJ, Chow BJ, Beanlands RS, Haddad H, Mielniczuk LM. Imaging the failing right ventricle. Curr Opin Cardiol. 2012;27(2):148-53.
  • *Shukla T, Nichol G, Wells G, deKemp RA, Davies RA, Haddad H, Duchesne L, Freeman M, Gulenchyn K, Racine N, Humen D, Benard F, Ruddy TD, Chow BJ, DaSilva J, Garrard L, Guo A, Chen L, Beanlands RS. Does FDG PET-assisted management of patients with left ventricular dysfunction improve quality of life? A substudy of the PARR-2 trial. Can J Cardiol.2012;28(1):54-61.
  • Lortie M, Dasilva JN, Kenk M, Thorn S, Davis D, Birnie D, Beanlands RS, Dekemp RA. Analysis of (R)- and (S)-[(11)C]rolipram Kinetics in Canine Myocardium for the Evaluation of Phosphodiesterase-4 with PET. Mol Imaging Biol. 2012;14(2):225-36.
  • *Mylonas I, Kazmi M, Fuller L, Dekemp RA, Yam Y, Chen L, Beanlands RS, Chow BJ. Measuring coronary artery calcification using positron emission tomography-computed tomography attenuation correction images. Eur Heart J Cardiovasc Imaging. 2012 Apr 17. [Epub ahead of print]
  • Bogiatzi, C., Cocker, M. S., Beanlands, R., Spence, J. D. Identifying high-risk asymptomatic carotid stenosis. Expert Opinion on Medical Diagnostics 2012;6(2), 139-151.
  • Valdivia AC, Estrada M, Hadizad T, Stewart DJ, Beanlands RS and DaSilva JN. A fast, simple and reproducible automated synthesis of [18F]FPyKYNE-c(RGDyK) for alphavbeta3 receptor PET imaging. J Label Cpd Radiopharm. 55(2), 57-60.
  • So PP, Davies RA, Chandy G, Stewart D, Beanlands RS, Haddad H, Pugliese C, Mielniczuk LM. Usefulness of Beta-Blocker Therapy and Outcomes in Patients With Pulmonary Arterial Hypertension. Am J Cardiol. 2012 Feb 29. [Epub ahead of print]

Submitted Manuscripts:

  • Ahmadi A, Manthorp E, Vulesevic B, Toeg H, DaSilva JN, Kordos M, Thorn S, Renaud JM, Kuraitis D, Giordano G, Sofrenovic T, Mesana TG, Beanlands RS, deKemp RA, Ruel M, Suuronen EJ. Improved Myocardial Perfusion, Viability and Function in Infarcted Hearts after Collagen Matrix-Enhanced Cell Therapy is Associated with an Integrin-Linked Kinase Mechanism. J Am Coll Cardiol. 2011 (submitted)
  • Bogiatzi C, Cocker MS, Beanlands R, Spence JD. Identifying high-risk asymptomatic carotid stenosis. Expert Opin Med Diagnostics 2012. (submitted)
  • McArdle B, Ziadi MC, Beanlands RS. Nuclear Perfusion Imaging for functional evaluation of patients with known or suspected coronary artery disease. The future is now! Future Cardiology 2012 (submitted)
  • Giordano C, Kuraitis D, Beanlands RS, Suuronen EJ, Ruel M. Cell-based therapeutic vasculogenesis in pre-clinical models of chronic myocardial ischemia and hibernation. J Am Coll Cardiol. 2012 (submitted)