Weekly Research Conference presents Dr Alexandre Stewart

November 20, 2017 - 12:00 p.m. to 1:00 p.m.
Alexandre Stewart, PhD

Alexandre Stewart, PhD

Scientist, University of Ottawa Heart Institute

Director, Laboratory of Translational Cardiovascular Genomics;
Ruddy Canadian Cardiovascular Genetics Centre,
University of Ottawa Heart Institute

Full Professor of Medicine, Department of Biochemistry, Microbiology and Immunology
University of Ottawa

Does shortening the message enable escape from inflammation in coronary artery disease?

Learning objectives:
1) To understand how a transcription cofactor suppresses inflammation in macrophages.
2) How the mRNA for this transcription cofactors gets shorter with inflammation by a mechanism of alternative polyadenylation. WHat is alternative polyadenylation and what does it do?
3) How a genetic variant prevents this shortening and what the consequences are of this effect.


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