De Bold, Adolfo

Overview 

Adolfo de Bold is Director of the Cardiovascular Endocrinology Laboratory at the University of Ottawa Heart Institute and Professor of Pathology and Cellular and Molecular Medicine at the University of Ottawa.

De Bold discovered that the heart has an endocrine function; one of the major cardiovascular discoveries of the past 50 years. His work on atrial natriuretic factor (ANF), the cardiac polypeptide hormone previously unknown to the scientific community, has been recognized through numerous national and international distinctions and awards.

Background 

De Bold completed his university training at the Faculty of Chemical Sciences at the National University of Córdoba, Argentina, where he obtained a professional degree in Clinical Biochemistry. In 1968, he continued his research and studies in the Department of Pathology at Queen’s University in Kingston, Ontario, where he obtained a PhD in Pathology.

Most of de Bold’s research has been dedicated to the study of storage granules in heart cells. In 1980, this work led to his discovery and isolation of ANF. This discovery, the result of 12 years of dedicated research, revealed that the heart possesses an endocrine function: through ANF, the heart modulates blood pressure, blood volume and cardiovascular growth at multiple levels.

This incredible finding altered the scientific community’s understanding of the heart’s physiology and function, and triggered worldwide research on ANF. To date, more than 10,000 basic and clinical science papers on ANF have been published around the world. This field of research has now matured into clinical therapeutic and diagnostic applications in the treatment of heart failure.

The discovery has made de Bold one of the most cited Canadian authors. He has given more than 150 invited lectures worldwide on his field of interest. His work on ANF was declared the first of the top 10 research accomplishments funded by the Heart and Stroke Foundation of Ontario in the past 50 years.

De Bold’s work on ANF has been recognized through numerous distinctions and awards. These include the Gairdner Foundation International Award, the Royal Society of Canada McLaughlin Medal in Medical Research, the Ernest C. Manning Principal Award, the International Society for Hypertension Research Award, and the American Society for Hypertension Award, among others. Adolfo de Bold is an Officer of the Order of Canada.

Adolfo de Bold has contributed to the field of cardiovascular research as a teacher, administrator and scientist. He was a key contributor to the establishment of the Research Centre at the University of Ottawa Heart Institute.

Research & Clinical Interests 

De Bold’s research activities centre on the endocrine function of the heart. Through this function, the heart produces and secretes into the circulation two hormones referred to as ANF and BNP. The multiple beneficial actions of these hormones include a role in the regulation of water and salt balance of the body and other parameters that directly affect blood pressure and cardiac workload. In addition, the hormones themselves are used as therapeutic drugs.

The research spans multiple aspects of the endocrine function of the heart, including the basic aspects of the mechanism of secretion of the hormones from the heart to their role in clinical entities such as heart failure and inflammation. In addition, a long-acting analogue of ANF is being developed to obtain a drug that may be used in heart failure and other important clinical entities.

Publications 

LATEST PUBLICATIONS

  • Ogawa T, Forero M, Burgon PG, Kuroski de Bold ML, Georgalis T, de Bold AJ. Role of potassium channels in stretch-promoted atrial natriuretic factor (ANF) secretion. J Am Soc Hyperten 2009 (in press).
  • de Bold AJ. Cardiac natriuretic peptides gene expression and secretion in inflammation. Invest Med 2008 (in press).
  • McGrath MF, Kuroski de Bold ML, de Bold AJ. Transcriptional analysis of the heart with special reference to its endocrine function. (Submitted for publication, 2008.)
  • de Bold AJ. Update on the functions of natriuretic peptides. 16th World Congress of Cardiology, Buenos Aires, Argentina, May 21, 2008.
  • Ogawa T, Venoit JP, Kuroski de Bold ML, de Bold AJ. BNP is uniquely regulated during inflammation.14th World Congress on Heart Disease, Intern Acad Cardiol Annual Scientific Sessions, Toronto, Canada, July 26-29, 2008. J Heart Disease 6(1):132, 2008.

PAPERS IN REFEREED JOURNALS

  • Rabbit Pancreatic Cell. Morphological and Functional Studies During Embryonal and Post-Natal Development. Bencosme, S.A., Wilson, M.B., Aleyassine, H., de Bold, A.J., and de Bold, M.L. Diabetologia, 6:399-411, 1970.
  • Studies on the Relationship between the Catecholamine Distribu¬tion in the Atrium and the Specific Granules Present in Atrial Muscle Cells. I. Isolation of a Purified Specific Granule Subtraction. de Bold, A.J., and Bencosme, S.A. Cardiovas. Res., 7:351-363, 1973.
  • Studies on the Relationship between the Catecholamine Distribu¬tion in the Atrium and the Specific Granules Present in Atrial Muscle Cells. II. Studies on the Sedimentation Pattern of Atrial Noradrenaline and Adrenaline. de Bold, A.J., and Bencosme, S.A. Cardiovas. Res., 7:364-369, 1973.
  • Autoradiographic Analysis of Label Distribution in Mammalian Atrial and Ventricular Cardiocytes After Exposure to Tritiated Leucine. de Bold, A.J., and Bencosme, S.A. In: Recent Advances in Studies on Cardiac Structure and Metabolism, Vol. 8, University Park Press, Baltimore, 1975.
  • Selective Light Microscopic Demonstration of the Specific Granulation of the Rat Atrial Myocardium by Lead-Haematoxylin- Tartrazine. de Bold, A.J., and Bencosme, S.A. Stain Technology, 50:203-205, 1975.
  • An Improved Method for the Production of Experimental Congestive Heart Failure in the Guinea Pig. Ling, E.T., and de Bold, A.J. Lab. Animals, 10:285-289, 1976.
  • Demonstration of Specific Atrial Granules by Aldehyde Fuchsin. Raymond, J.J., de Bold, A.J., and Bencosme, S.A. Proc. Microscopical Soc. Canada, 3:92, 1976.
  • Demonstration of a Tryptaminergic Mechanism in the Rat-Cell. Pulido, O., de Bold, A.J., de Bold, M.L., and Bencosme, S.A. Experientia, 33:268, 1977.
  • Morphometric Assessment of Granulation in Rat Atrial Cardiocytes: Effect of Age. de Bold, A.J. J. Molec. Cell Cardiol., 10:717-724, 1978.
  • Intracellular Pancreatic Cell Serotonin and the Dynamics of In¬sulin Release. Pulido, O.M., Bencosme, S.A., de Bold, M.L., and de Bold, A.J. Diabetologia, 15:197-204, 1978.
  • Atrial Specific Granules of the Rat Heart. Light Microscopic Staining and Histochemical Reactions. de Bold, A.J., Raymond, J.J., and Bencosme, S.A. J. Histochem. Cytochem., 26:1094-1102, 1978.
  • Heart Atria Granularity. Effects of Changes in Water Electrolyte Balance. de Bold, A.J. Proc. Soc. Exptl. Biol. Med., 161:508-511, 1979.
  • Structural Relationships Between Parenchymal and Stromal Elements in the Pars Intermedia of the Rat Adenohypophysis as Demonstrated by Extracellular Space Markers. de Bold, A.J., de Bold, M.L., and Kraicer, J. Cell and Tissue Research, 207:347-359, 1980.
  • Pyruvate Kinase Levels in the Lymphocytes of Malnourished Anergic Patients. Wren, S.F.G., Crowe, M., Lowe, P.J., and de Bold, A.J. J. Surgical Research, 29:203-208, 1980.
  • A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats. de Bold, A.J., Borenstein, H.B., Veress, A.T., and Sonnenberg, H. Life Sciences, 28:89-94, 1981.
  • Myocardial Glycolytic and Gluconeogenic Enzyme Activity During Cardiopulmonary Bypass in Humans. Wren, S.F.G., Salerno, T.A., Crowe, M., and de Bold, A.J. Can. J. Surg., 24:604-605, 1981.
  • Intrarenal Localisation of the Natriuretic Effect of Cardiac Atrial Extract. Sonnenberg, H., Cupples, W.A., de Bold, A.J., and Veress, A.T. In: Hormonal Regulation of Epithelial Transport of Ions and Water, (Eds. Scott, W.N., and Goodman, D.B.P.), The New York Academy of Sciences, New York, pp. 213-214, 1981.
  • Tissue Fractionation Studies on the Relationship Between an Atrial Natriuretic Factor and Specific Atrial Granules. de Bold, A.J. Can. J. Physiol. Pharmacol., 60:324-330, 1982.
  • Atrial Natriuretic Factor of the Rat Heart. Studies on Isolation and Properties. de Bold, A.J. Proc. Soc. Exptl. Biol. Med., 170:133-138, 1982.
  • Intrarenal Localisation of the Natriuretic Effect of Cardiac Atrial Extract. Sonnenberg, H., Cupples, W.A., de Bold, A.J., and Veress, A.T. Can. J. Physiol. Pharmacol., 60:1149-1152, 1982.
  • Natriuretic Activity of Extracts Obtained from Hearts of Different Species and from Various Rat Tissues. de Bold, A.J., and Salerno, T.A. Can. J. Physiol. Pharmacol., 61:127-130, 1983.
  • Cardionatrin* I. A Novel Heart Peptide with Potent Diuretic and Natriuretic Properties. de Bold, A.J., and Flynn, T.G. Life Sciences, 33:297-302, 1983. *: cardionatrin is an early name for ANF. Cardionatrin I. de Bold, A.J.In: Annual Drug Refer, Vol. 5, J.R. Prous Press, Barcelona, 1983.
  • The Amino Acid Sequence of an Atrial Peptide with Potent Diuretic and Natriuretic Properties. Flynn, T.G., de Bold, M.L., and de Bold, A.J. Biochem. Biophys. Res. Commun., 117:859-865, 1983.
  • Natriuretic Effect of Atrial Extract on Isolated Perfused Kidney. Baines, A.D., de Bold, A.J., and Sonnenberg, H. Can. J. Physiol. Pharmacol., 61:1462-1466, 1983.
  • Demonstration of Stellate Cells of the Pars Intermedia of the Pituitary Gland Using a New Silver Impregnation Technique. de Bold, M.L., de Bold, A.J. and Kraicer, J. Stain Technol., 59:49-52, 1984.
  • Isolation and Nucleotide Sequence of a Cloned Cardionatrin cDNA. Kennedy, B.P., Marsden, J.J., Flynn, T.G., de Bold, A.J., and Davies, P.L. Biochem. Byophys. Res. Commun., 122:1076-1082, 1984.
  • Alignment of Rat Cardionatrin Sequences with the cDNA Derived Se¬quence of Preprocardionatrin. Flynn, T.G., Davies, P.L., Kennedy, B.P., de Bold, M.L., and de Bold, A.J. Science, 228:323-325, 1985.
  • Immunocytochemical Demonstration of Cardionatrins in Human Atrial Myocardium. de Bold, M.L., and de Bold, A.J. In: Immunocytochemistry in Tumour Diagnosis, (Ed. J. Russo), Martinus Nijhoff Publishing, Boston, Mass., pp. 202-206, 1985.
  • Atrial Natriuretic Factor. de Bold, A.J. In: Nephrology Today. Proceedings of the IXth International Congress of Nephrology, Springer-Verlag, New York, pp.257-259, 1985.
  • Main Forms of Immunoreactive Cardionatrin in Atrial Extracts and in Atrial Specific Granules. Flynn, T.G., de Bold, A.J., de Bold, M.L., Davies, P.L., and Kennedy, B.P. Biochemical Society Transactions, 13:1141, 1985.
  • Atrial Natriuretic Factor. Historical Introduction and Overview. de Bold, A.J. In: Peptides: Structure and Function, (Eds. Deber, C.M., Hruby, V.J., and Kopple, K.D.), Proceedings of the Ninth Annual American Peptide Symposium, Toronto, Ontario, June 24-28, pp. 909-915, 1985.
  • Atrial Natriuretic Factor: Polypeptide Hormone Produced by the Heart. de Bold, A.J. Science, 230:767-770, 1985.
  • Rapid Ventricular Pacing in the Dog: Pathophysiologic Studies of Heart Failure. Armstrong, P.W., Stopps, T.P., Ford, S.E., and de Bold, A.J. Circulation, 74:1075-1084, 1986.
  • Functional-Morphological Studies on In Vitro Cardionatrin Release. de Bold, A.J., de Bold, M.L., and Sarda, I.R. J. Hypertension, 4: S3-S7, 1986.
  • Morphological and Biochemical Aspects of Atrial Natriuretic Fac¬tor (Cardionatrins). de Bold, A.J., Davies, P.L., de Bold, M.L., Flynn, T.G., Kennedy, B.P., Marsden, J.J., Sarda, I.R., and Tadross, O.
  • NAITO Foundation International Symposium on Natural Products and Biological Activities. Eds. H. Imura, T.Goto, T. Murachi and T. Nakajima), University of Tokyo Press, pp 325-333, 1986.
  • Atrial Natriuretic Factor: An Overview. de Bold, A.J. Fed. Proc., 45:2081-2085, 1986.
  • Lack of Interaction Between Atrial Natriuretic Factor and Renal Organic Anion Transport System. Goldinger, J.M., Hong, R.B., Lee, S.H., de Bold, A.J., and Hong, S.K. Proc. Exp. Biol. Med., 182:358-363, 1986.
  • Atrial Natriuretic Factor and Renal Function During Head-Out Water Immersion in Conscious Dogs.
  • Miki, K., Hajduczok, G., Klocke, M.R., Krasney, J.A., Hong, S.K. and de Bold, A.J. Am. J. Physiol., 25:R1000-R1004, 1986.
  • Atrial Natriuretic Factor: A Hormone Produced by the Heart. de Bold, A.J. In: Biotechnology; The Renewable Frontier, (Ed. Koshland, D.E.) pp 217-224, 1986.
  • Nomenclature For Atrial Peptides Dzau, V.J., Baxter, J.D., Cantin, M., de Bold, A.J., Ganten, D., Gross, K., Husain, A., Inagami, T., Menard, N., Poole, S., Robertson, J.I.S., Tang, J., and Yamamoto, K. N. Engl. J. Med., 316:1278-1279, 1987.
  • Functional Morphology of the Endocrine Component of the Heart. de Bold, A.J. In: American Society of Hypertension Symposium Series, Biologically Active Atrial Peptides, (Eds. Brenner, B.M. and Laragh, J.H.), New York, Raven Press, 1:1-2, 1987.
  • Atrial Stretch-Secretion Coupling and Immunoreactive Cardionatrin (IRC) Release In Vitro: Effect of Ca2+ and EGTA. de Bold, M.L. and de Bold, A.J. In: American Society of Hypertension Symposium Series, Biologically Active Atrial Peptides, (Eds. Brenner, B.M. and Laragh, J.H.), New York, Raven Press, 1:173-175,1987.
  • Relation Between Atrial Specific Granules and Cardionatrin Synthesis and Storage in the Rat. Tadross, O.E., Sarda, I.R., Davies, P.L. and de Bold, A.J. In: American Society of Hypertension Symposium Series Biologically Active Atrial Peptides, (Eds. Brenner, B.M. and Laragh, J.H.), New York, Raven Press, 1:158-162, 1987.
  • Study on the Factors Affecting the Radioimmunoassay of Cardionatrin. Sarda, I.R. and de Bold, A.J. In: American Society of Hypertension Symposium Series, Biologically Active Atrial Peptides, (Eds. Brenner, B.M. and Laragh, J.H.), New York, Raven Press, 1:213-215, 1987.
  • Effect of Head-Out Immersion on Plasma Atrial Natriuretic Factor in Man. Pendergast, D.R., de Bold, A.J., Pazik, M. and Hong, S.K. Proc. Soc. Exptl. Biol. Med., 184:429-435, 1987.
  • Historical Perspectives of Atrial Specific Granules. de Bold, A.J. In: Atrial Hormones and Other Natriuretic Factors (Mulrow, P.J. and Schrier, R. Eds.)Clinical Physiology Series, American Physiological Series, pp 1-5, 1987.
  • Factors Affecting the Release of Immunoreactive Cardionatrin (IRC) In Vitro From Human and Rat Atria. de Bold, A.J., de Bold, M.L., Taichman, G.C., Boyd, D.A. and Keon, W.J. The Second World Congress on Biologically Active Atrial Peptides, New York, N.Y., May 20-21, 1987.
  • On the Shoulders of Giants: The Discovery of Atrial Natriuretic Factor. de Bold, A.J. Can. J. Physiol. Pharmacol., 65:2007-2020, 1987.
  • Factors Affecting Cardionatrin Release. de Bold, A.J. and de Bold, M.L. In: Highlights On Endocrinology (Eds. Christiansen, C. & Riis, B.J.), Norhaven Bogtrykkeri A/S, Copenhagen, pp. 161-163, 1987.
  • Natriuretic Factors in Normotensive and Hypertensive Pregnancies: Preliminary Study of Water Immersion in Preeclampsia. Gregoire, I., Fievet, P., Roth, D., El Esper, N., Favre, H., Westeel, P., de Bold, A., and Fournier, A. Am. J. Hypertension, 5: S83-S85, 1987.
  • Atrial Natriuretic Factor. de Bold, A.J., de Bold, M.L. and Reuben, M.M. In: Proceedings of the Xth International Congress of Nephrology, (Ed. Davison, A.M.), London, England,1: 109-122, 1988.
  • Atrial Natriuretic Factor During Head-Out Immersion at Night. Miki, K., Shiraki, K., Sagawa, S., de Bold, A.J., and Hong, S.K. Am J. Physiol 254 (Integrative and Comp. Physiol. 23): R235-R241, 1988
  • Atrial Natriuretic Factor in Pregnancy-Induced Hypertension and Preeclampsia: Increased Plasma Concentrations Possibly Explain¬ing These Hypovolemic States with Paradoxical Hyporeninism. Fievet, P., Fournier, A., de Bold, A.J., El Esper, N., Gregoire, I., Westeel, P.F., Renaud, H. and Makurssi, R. Am. J. Hypertension, 1:16-21, 1988.
  • Oubain-Like Natriuretic Factor and Atrial Natriuretic Factor in Pregnancy. Fievet, P., Gregoire, I., Fournier, A. Roth, D., Siegenthaler, G., El Esper, N., Favre, H., and de Bold, A.J. Kidney International, 34: S89-S92, 1988.
  • Physiological Effects of Synthetic Atrial Natriuretic Factor in Normal Conscious Dogs. Moe, G.W., Forster, C., de Bold, A.J., Armstrong, P.W. Clinical and Investigative Medicine, 11: 417-424, 1988.
  • Alterations in Serum Sodium in Relation to Atrial Natriuretic Factor and Other Neuroendocrine Parameters in Experimental Pacing- Induced Heart Failure. Moe, G.W., Stopps, T.P., Angus, C., Forster, C., de Bold, A.J., and Armstrong, P.W. J.Am.Coll.Cardiol. 13: 173-179, 1989
  • Effect of Manipulations of Ca2+ Environment on Atrial Natriuretic Factor Release. de Bold, M.L. and de Bold, A.J. Am. J. Physiol., 256: H1588-H1594, 1989.
  • Effect of Rat Cardionatrin I (Rat ANF 99-126) on the Response of Toad Skin to Angiotensin II. Coviello, A., Soria, M.O., Proto, M.C., Berman, D.M., Gamundi, S.S., Alonso, C.E.I. and de Bold, A.J. Can. J. Physiol. Pharmacol., 67: 362-365, 1989.
  • Optimization of Atrial Natriuretic Factor Radioimmunoassay. Sarda, I.R., de Bold, M.L., and de Bold, A.J. Clin Biochem, 22: 11-15, 1989.
  • Atrial Natriuretic Factor. de Bold, A.J., de Bold, M.L., and Reuben, M.M. In: Prohormones, Hormones and their Fragments: Processing Biological Activity and Pharmacology, ED: J. Martinez, Ellis Horwood Ltd., Chapter 11, 317-324, 1989.
  • Atrialer Natriuretischer Faktor (ANF) und Ouabain-Ersetzender Faktor (ODF) Bei Normotensiver und Hypertensiver Schwangerschaft. Fournier, A., Fievet, P., Gregoire, I, El Esper, N., Esteel, P., Lalau, J.D., Makdassi, R., Favre, H., and de Bold, A.J. Nieren-und Hochdruckkrankheiten, Jahragang 18, Nr. 8/1989, S329-S334.
  • Sequential Study of the Plasmatic Atrial Natriuretic Factor and the Urinary Excretion of an Ouabain Displacing Factor and of Dopamine in Normotensive Pregnant Women before and after Labour. el Esper N., Gregoire I, Fievet P, Lalau J.D., Westeel P.F., Favre H., de Bold A.J., Fournier, A. Archives Des Maladies Du Coeur Et Des Vaisseaux 82: 1057, 1989.
  • Plasma Atrial Natriuretic Factor and Urinary excretion of a Ouabain Displacing Factor and Dopamine in Normotensive Pregnant Women before and after Delivery. Gregoire, I., el Esper N., Gondry, J., Boitte, F., Fievet, P., Makdassi, R., Westeel P.F., Lalau, J.D., Favre H., de Bold A.J. and Fournier, A. Am. J. Obst. Gynecol. 162:71, 1990
  • Pharmacokinetics, Hemodynamic, Renal, and Neurohormonal effects of Atrial Natriuretic Factor in Experimental Heart Failure. Moe, G.W., Forster, C., de Bold, A.J., Armstrong, P.W Clinical & Investigative Medicine - Medicine Clinique Et Experimentale 13: 111, 1990
  • Pathophysiological Role of Changing Atrial Size and Pressure in Modulation of Atrial Natriuretic Factor during Evolving Experimental Heart Failure. Moe, G.W., Angus, C., Howard, R.J., de Bold, A.J., Armstrong, P.W. Cardiovasc. Res.24: 570, 1991
  • Stretch Secretion Coupling in Atrial Cardiocytes: Dissociation Between ANF Release and Atrial Contractility Kuroski-de Bold, M.L., de Bold, A.J. Hypertension 18: III-169-III-178, 1991.
  • A Decade of ANF Research. de Bold, A.J., de Bold, M.L., Boer P.H., Mangat, H., Dubé, G., Johnson, F. Can. J. Physiol. Pharmacol. 69: 1480-1485 1991
  • Atrial Natriuretic Factor in Pregnancy and Pregnancy Induced Hypertension Fournier, A., Gregoire, I., El Esper, N., Lalau, J.D., Westeel, P.F., Makdassi, R., Fievet, P., de Bold, A.J. Can. J. Physiol. Pharmacol., 69:1601-1608, 1991
  • Post-Transcriptional Processing of Atrial Natriuretic Factor by Adult Rat Atrial Cardiocytes in Culture. Dubé, G.R., Kuroski-de Bold, M.L. and de Bold, A. J. Can. J. Physiol. Pharmacol., 69: 1480-1485, 1993
  • Stretch-Induced Atrial Natriuretic Factor Release Utilises a Rapidly Depletable Pool of Newly Synthesised Hormone. Mangat, H. and de Bold, A.J. Endocrinology 133: 1398-1403, 1993
  • Neuroendocrine Response to Cardiac Transplantation. Masters, R. G., Koshal, A., Davies, R.A., Keon, W.J. and de Bold, A.J. Can. J. Cardiol., 9:609-617, 1993
  • Atrial Natriuretic Factor in Experimental Acute Chagas' Disease. Piazza, L.A., de Bold, A.J., Santamarina, N., Hliba, E., Rudiolo, E.R. Parasitol. Res. 80: 78-80, 1994
  • Epicardial Mesothelial Cells Synthesise and Release Endothelin Eid, H., Kuroski -de Bold, M.L., Chen, J.H. and de Bold, A.J. J.Cardiovasc.Pharmacol. 24: 715-720, 1994.
  • Selective Changes in Natriuretic Peptide and Early Response Gene Expression in Isolated Rat Atria Following Stretch Or Endothelin-1 Bruneau, B. and de Bold, A.J. Cardiovasc. Res. 28: 1519-1525, 1994.
  • Atrial natriuretic Factor Contributes to the Mineralocorticoid Escape Phenomenon: Evidence For A Guanylate Cyclase-Mediated Pathway Yokota,N., Bruneau,B.G., Kuroski-de Bold, M.L. and de Bold,A.J. J.Clin.Invest. 94: 1938-1946, 1994.
  • Regulation of alpha-smooth actin expression in adult cardiomyocytes through a tyrosine kinase signal transduction pathway Eid,H., Chen, J.H. and de Bold,A.J. Ann.N.Y.Acad.Sci., 752: 192-201, 1995.
  • Dissociation of Cardiac Hypertrophy, Myosin Heavy Chain Isoform Expression, and Natriuretic Peptide Production in DOCA-salt Rats Yokota,N., Bruneau,B.G., Fernandez,B.E., Kuroski-de Bold, M.L., Piazza,L.A., Eid,H. and de Bold,A.J. Am.J.Hyperten.8: 301-310, 1995
  • α1-Adrenergic Stimulation of Isolated Rat Atria Results in Discoordinate Increases in Natriuretic Peptide Secretion and Gene Expression, and Enhances Egr-1 and c-myc Expression Bruneau B.G.,. Piazza L. A, and de Bold A. J. Endocrinology 137: 137-143, 1996
  • Effects of Renal Neutral Endopeptidase Inhibition on Sodium Excretion, Renal Hemodynamics and Neurohormonal Activation in Patients with Congestive Heart Failure. Kimmelstein, C.D., Perrone, R., Kilcoyne, L., Souhrada, J., Udelson, J., Smith, J., de Bold, A.J., Griffith, J. and Konstam, M.A. Cardiology 87: 46-53, 1996
  • Mechanical and Neuroendocrine Regulation of the Endocrine Heart de Bold, A.J., Bruneau, B.G. and Kuroski de Bold,M.L. Cardiovasc. Res. 31:7-18, 1996
  • Evidence for Load-dependent and Load-independent Determinants of Cardiac Natriuretic Peptide Production Ogawa, T., Linz,W., Stevenson, M., Bruneau, B.G., Kuroski de Bold,M.L., Chen,J.H. , Eid,H., SchölkensB.A. and de Bold,A.J. Circulation 93: 2059 2067, 1996
  • Mechanical and Receptor-Mediated Modulation of Endocrine Function in Isolated Rat Atria. Selective Enhancement of Brain Natriuretic Peptide Gene Expression. Bruneau, B.G., Piazza, L.A., and de Bold,A.J. Am J Physiol. 273: H2678-H2686, 1997
  • Tissue Specific Regulation of Renal and Cardiac Atrial Natriuretic Factor Gene Expression in DOCA-Salt Rats. Ogawa, T., Bruneau, B.G., Yokota,N., Kuroski de Bold, M.L., and de Bold, A.J. Hypertension 30: 1342-1347, 1997
  • Regulation of Aortic Atrial Natriuretic Factor and Angiotensinogen in Experimental Hypertension Tsuneo Ogawa, Wolfgang Linz, Bernward A.Schölkens, Adolfo J. de Bold Cardiovasc.Pharmacol., 32: 1001-1008, 1998
  • Variable Renal Atrial Natriuretic Factor Gene Expression in Experimental Hypertension Tsuneo Ogawa, Wolfgang Linz, Bernward A. Schölkens, Adolfo J. de Bold Hypertension, 33:1342-7, 1998
  • Characterization of Natriuretic Peptide Production By Adult Heart Atria Tsuneo Ogawa, Marcelo Vatta, Adolfo J. de Bold. Am. J. Physiol., 276:H1977-86, 1999
  • Discoordinate Modulation of Natriuretic Peptides During Acute Cardiac Allograft Rejection In Humans. Masters, R.G., Davies R. ,Veinot, J.P., Hendry, P.J., Smith, S.J., de Bold, A.J. Circulation, 100: 287-91, 1999
  • Natriuretic Peptides de Bold, A.J. and Bruneau, B.G. Invited Chapter. Handbook of Physiology, Section 7, The Endocrine System. VolumeIII: Endocrine Regulation of Water and Electrolyte Balance. John C.S. Fray, Volume Editor, H. Maurice Goodman, Section Editor. pp 377-409, 2000
  • Effect Of Selective EtA Receptor Blockade On Natriuretic Peptide Gene Expression In Doca-Salt Hypertension. Bianciotti, Liliana G. and de Bold, Adolfo J. Am J Physiol Heart. 279: H93-H101 2000
  • Modulation Of Cardiac Natriuretic Peptide Gene Expression Following Endothelin Type A Receptor Blockade In Renovascular Hypertension Bianciotti, Liliana G. and de Bold, Adolfo J. Circulation Research, 49: 808-816, 2001
  • A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Reprinted from Life Sci. 28:89-94, 1981. de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. J Am Soc Nephrol. Feb;12(2):403-9, 2001. Discussion 403-8, 408-9.
  • The Atrial Natriuretic Factor Family of Polypeptide Hormones de Bold, Adolfo J.
  • Invited entry for The Encyclopedia of Molecular Medicine, Thomas E. Creighton, Editor. John Wiley & Sons, Inc., New York, NY. 2001
  • Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Mol Cell Biol 21:1730-6, 2001
  • The Physiological and Pathophysiological Modulation of the Endocrine Function of the Heart. Adolfo J. de Bold, Kenneth K-Y Ma, Ying Zhang, Mercedes L. Kuroski de Bold, Michael Bensimon, Ali Khoshbaten. Can.J.Physiol.Pharmacol.70: 705-714, 2001
  • Atrial Natriuretic Factor Gene Expression In Doca-Salt Hypertension Following Blockade Of The Type B Endothelin Receptor Bianciotti, Liliana G. and de Bold, Adolfo J. Am.J.Physiol. 282: H1127-H1134, 2002
  • Gene Expression of Natriuretic Peptides (NPs) and Their Receptors (NPRs) In Human Coronary Arteries. V.H. Casco , J.P. Veinot, M. L. Kuroski de Bold, R.G. Masters, M. A. Stevenson and A.J. de Bold. J. Histochem. Cytochem. 50: 799, 2002
  • Discoordinate re-expression of cardiac fetal genes in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension. Zhang, Y, Carreras, D. and de Bold, A.J. Cardiovasc Res. 571:158-67, 2003
  • Brain Natriuretic Peptide Gene Expression and Secretion is Selectively Up-Regulated by Pro-inflammatory Cytokines IL-1, TNF- and Conditioned Medium Derived from Mixed Lymphocyte Reactions. Ma, K. K-Y and de Bold, Adolfo J. J. Cell Molec.Cardiol. 36: 505-513, 2004.
  • B-Type Natriuretic Peptide Predicts Successful Cardioversion in Patients with Atrial Fibrillation and Maintenance of Sinus Rhythm. Beck-da-Silva, L, de Bold, A.J., Fraser, M. Williams, K., Struthers, C., Davies, R. and Haddad, H. Can.J.Cardiol. 20: 1245-1248, 2004
  • Participation of G Proteins in Natriuretic Peptide Hormone Secretion from Heart Atria. Bensimon, M. Chang, A.I., Kuroski de Bold, M.L., Ponce, A., Carreras, D. and de Bold, A.J. Endocrinology 145: 5313-5321, 2004
  • Effect of Bisoprolol on Right Ventricular Function and Brain Natriuretic Peptide in Patients with Heart Failure. Beck-da-Silva, L., de Bold, A.J., Davies, R.A., Chow, B.J.W., Ruddy, T.D., Fraser, M., Struthers, C. and Haddad, H. Cong.Heart Fail.J. 10: 127-132, 2004.
  • Brain Natriuretic Peptide as a Guide to Beta-Adrenergic Blocker Titration in Patients with Heart Failure. Beck-da-Silva, L., de Bold, A.J., Davies, R.A., Chow, B.J.W., Ruddy, T.D., Fraser, M., Williams, K., Struthers, C. and Haddad, H. Congestive Heart Failure 11:248-253, 2005.
  • Determinants of Inducible Brain Natriuretic Peptide Promoter Activity Ma, K. K., Banas, K. and de Bold, A.J. Regulatory Peptides 128: 169– 176, 2005
  • Determinants of natriuretic peptide gene expression. McGrath,M.F. and de Bold,A.J. Peptides 26:933-943,2005.
  • Neuroendocrine Profiling of Humans Receiving Cardiac Allografts. Ogawa, T., Veinot, J.P., Davies, R.A., Haddad, H., Smith, S.J., Masters, R.G., Hendry, P.J., Starling, R., Kuroski de Bold, M.L., Ponce, A., Ma., K.K., Williams, K., de Bold, A.J. J. Heart Lung Transp. 24: 1046-1054, 2005
  • The endocrine function of the heart. McGrath, M.F., Kuroski de Bold, M.L. and de Bold, A.J. Trends Endocrinol Metab. 16:469-77, 2005
  • Determinants of natriuretic peptide production by the heart: basic and clinical implications. de Bold, A.J. and de Bold, M.L. J Investig Med 53:371-7, 2005
  • Gene Expression, Processing and Secretion of Natriuretic Peptides. Physiological and Diagnostic Implications, Ramos, H. and de Bold, A.J. Clinics of North America, Heart Failure Clinics 2 (3): 255, 2006
  • Determinants of Brain Natriuretic Peptide (BNP) Gene Expression and Secretion in Acute Cardiac Allograft Rejection. Adolfo J. de Bold. Current Opinions in Cardiology 22: 146-150, 2007
  • Relationship between Natriuretic Peptides and Inflammation. Proteomic Evidence Obtained during Acute Cardiac Allograft Rejection in Humans, Yael F. Meirovich, John P. Veinot, Mercedes L Kuroski de Bold, Haissam Haddad, Ross A. Davies, Roy G. Masters, Paul J. Hendry and Adolfo J. de Bold. Heart Lung Transplant. 27:31-7. 2008
  • Angiotensin II Receptor Antagonism Reverts Cardiac BNP Upregulation and Secretion Observed in Myocarditis, Tsuneo Ogawa; John P. Veinot; Tina Georgalis; Adolfo J. de Bold. Am.J.Physiol. 294: H5296, 2007
  • Cardiac Natriuretic Peptides Gene Expression and Secretion in Inflammation. de Bold, A.J. Invest. Med. 2008, In press
  • Role of potassium channels in stretch-promoted atrial natriuretic factor (ANF) secretion. Tsuneo Ogawa, MD, PhD, Monica Forero, BSc, Patrick G. Burgon, PhD, Mercedes L. Kuroski de Bold, PhD, Tina Georgalis, MSc and Adolfo J. de Bold, PhD* J.Am.Soc.Hyperten. 2009, In press
  • Transcriptional Analysis of the Heart with Special Reference to its Endocrine Function. McGrath, M.F., Kuroski de Bold, M.L. and de Bold, A.J. Submitted for publication, 2008
  • Update on the functions of natriuretic peptides. de Bold, A.J. XVI World Congress of Cardiology, Buenos Aires, Argentina, May 21, 2008
  • BNP is uniquely regulated during inflammation. Ogawa, T, Venoit, JP, Kuroski de Bold ML, de Bold, A J. 14th World Congress on Heart Disease, Intern Acad Cardiol Annual Scientific Sessions. Toronto, Canada, July 26-29, 2008 J Heart Disease 6(1):132, 2008.

ABSTRACTS

  • Morphological and Functional Studies on the Cell of the Embryonal Pancreas in the Rabbit. de Bold, A.J., Bencosme, S.A., Wilson, M.B., Aleyassine, H., and de Bold, M.L. Anat. Rec., 166:296, 1970.
  • Pancreatic Islet Cell Tumour Associated with Hyperinsulinism. Diagnostic Problems. Bencosme, S.A., Wilson, M.B., Aleyassine, H., de Bold, A.J., and de Bold, M.L. Annual Congress Quebec Association Lab. Physicians, 1971.
  • Norepinephrine Distribution During a Fractionation Procedure to Isolate Specific Granules from Atrial Homogenates. de Bold, A.J., and Bencosme, S.A. J. Cell Biol., 55:58a, 1972.
  • An Improved Method for Total Body Fixation by Intravascular Per¬fusion. de Bold, M.L., Feria-Velasco, A., Bencosme, S.A., and de Bold, A.J. Exptl. Biol. Med., (Champlain Section), May 1973.
  • Vascular Perfusion Fixation for Electron Microscopy: An Improved Method. de Bold, M.L., Feria-Velasco, A., Bencosme, S.A., and de Bold, A.J. Lab. Invest., 28: 382, 1973.
  • Subcellular Distribution of Endogenous Epinephrine and Norepinephrine in the Rat Atrium. de Bold, A.J., and Bencosme, S.A. Lab. Invest., 28: 382, 1973.
  • Autoradiographic Analysis of Label Distribution in Mammalian Atrial and Ventricular Cardiocytes After Exposure to Tritiated Leucine. de Bold, A.J., and Bencosme, S.A. Seventh Annual Meeting of the International Study Group for Research in Cardiac Metabolism, Quebec City, 1974.
  • Selective Demonstration of Specific Atrial Granules at the Light Microscopic Level. de Bold, A.J., and Bencosme, S.A. Lab. Invest., 32:6, 1975.
  • Histological and Autoradiographic Investigations on the Specific Granulation of the Atrial Myocardium. de Bold, A.J. Fed. Proc., 34:826, 1975.
  • Demonstration of Tryptaminergic Mechanism in the Rat Cell. Pulido, O.M., de Bold, A.J., de Bold, M.L., and Bencosme, S.A. Soc. Exptl. Biol. Med. (Champlain Section), May 1976.
  • Intracellular-Cell Serotonin and the Dynamics of Insulin Release. Pulido, O.M., Bencosme, S.A., de Bold, M.L., and de Bold, A.J. Lab. Invest., 36:348, 1977.
  • Morphometry of Atrial Granulation. Effect of Age. de Bold, A.J. J. Molec. Cell Cardio., 9:21, 1977.
  • Effect of Water, Sodium Restriction and Desoxycorticosterone on Granularity of Heart Atrial Muscle Cells. de Bold, A.J. Proc. Can. Fed. Biol. Soc., 21:139, 1978.
  • Renin-Like Activity in Rat Heart Atria. Rojo-Ortega, J.M., de Bold, A.J., and Bencosme, S.A. J. Molec. Cell Cardio., 11(Supp. 1):52, 1979.
  • Extracellular Space of the Pars Intermedia (PI) of the Rat Adenohypophysis as Revealed by Ruthenium Red (RR). de Bold, A.J., and Kraicer, J. Ann. R. Coll. Phys. Surg. (Canada), 12:41, 1979.
  • Pars Intermedia (PI) of the Rat Adenohypophysis: Its Extracel¬lular Space as Revealed by Horseradish Peroxidase (HRP). de Bold, A.J., and Kraicer, J. Fed. Proc., 38:979, 1979.
  • Pyruvate Kinase Levels in the Lymphocytes of Anergic Malnourished Patients. Wren, S.F., and de Bold, A.J. Presented to the Association for Academic Surgery Meeting, New Jersey, November 1979.
  • The Effect of Total Parenteral Nutrition (TPN) on the Kinetics of Intralymphocytic Pyruvate Kinase. Wren, S.F., and de Bold, A.J. Presented at the Am. Soc. Parenteral and Enteral Nutrition, Chicago, January 1980.
  • The Effect of Delayed Hypersensitivity Skin Testing on the Kinetics of Intralymphocytic Pyruvate Kinase in Humans. Wren, S.F.G., and de Bold, A.J. Proc. Can. Fed. Biol. Soc., 23:82, 1980.
  • Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats. de Bold, A.J., Borenstein, H.B., Veress, A.T., and Sonnenberg, H. Clin. Res., 28:658A, 1980.
  • Demonstration of Stellate-Shaped Cells in the Pars Intermedia (PI) of the Rat Hypophysis. de Bold, A.J., de Bold, M.L., Ludwin, S.K., and Kraicer, J. Clin. Res., 28:669A, 1980.
  • The Effect of Rapid Weight Loss (Jejeuno-Ileal Bypass-JIB) on the Kinetics of Intralymphocytic Pyruvate Kinase (PK) and Delayed Hy¬persensitivity Skin Testing. Wren, S.F., and de Bold, A.J. Clin. Res., 28:689A, 1980.
  • Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardium Extract in Rats. Sonnenberg, H., Veress, A.T., Borenstein, H.B., and de Bold, A.J. The Physiologist, 23:71, 1980.
  • Intrarenal Localisation of the Natriuretic Effect of Cardiac Atrial Extract. Sonnenberg, H., Cupples, W.A., de Bold, A.J., and Veress, A.T. Proc. N.Y. Acad. Sci., 1981 (NYAS Conference on Hormonal Regulation of Epithelial Transport. November 10-12, 1980).
  • Myocardial Glycolytic Enzyme Activity during Cardiopulmonary Bypass in Humans. Salerno, T.G., de Bold, A.J., and Wren, S.F.G. Can. J. Surg., 24:604, 1981.
  • Effect of Cardiac Atrial Extract on Segmental Nephron Transport in the Rat Kidney. Cupples, W.A., Veress, A.T., de Bold, A.J., and Sonnenberg, H. Proc. Fed. Am. Soc. Exptl. Biol., 40:554, 1981.
  • Natriuretic Factor (NF) of the Rat Heart Atria. Studies on Isolation and Properties. de Bold, A.J. Proc. Fed. Am. Soc. Exptl. Biol., 40:554, 1981.
  • Natriuretic Factor (NF) of the Rat Heart Atria. Studies on Isolation and Properties. de Bold, A.J. Proc. Can. Fed. Biol. Soc., 24:161, 1981.
  • Ultrastructure of the Innervation of the Pars Intermedia (PI) of the Rat Pituitary after Administration of 5-Hydroxydopamine. de Bold, M.L., de Bold, A.J., and Kraicer, J. Proc. Can. Fed. Biol. Soc., 24:231, 1981.
  • Demonstration and Microanatomical Distribution of Stellate Cells of the Pars Intermedia (PI) of the Rat Pituitary Using a Novel Silver Impregnation Technique. de Bold, M.L., de Bold, A.J., and Kraicer J. Proc. Microscop. Soc. Can., 8:80-81, 1981.
  • The Relationship Between Atrial Natriuretic Factor and Specific Atrial Granules. de Bold, A.J. Proc. Fed. Am. Soc. Exptl. Biol., 41:990, 1982.
  • Cardionatrin I. A Potent Diuretic and Natriuretic Peptide Iso¬lated from the Heart Atria. de Bold, A.J., and Flynn, T.G. Proc. Fed. Am. Soc. Exptl. Biol., 42:611, 1983.
  • Purification and Characterization of Rat Atrial Cardionatrins - Potential Diuretic, Natriuretic and Vasoactive Hormones. Flynn, T.G., de Bold, M.L. and de Bold, A.J. Proceedings of the 7th International Congress of Endocrinology. Excerpts Medica International Congress Series 652. Elsevier Science Publishing Co. Inc., New York, N.Y., pp 873, 1984.
  • Morphological and Biochemical Aspects of Atrial Natriuretic Fac¬tor (Cardionatrins). de Bold, A.J. Proceedings of the Naito Foundation International Symposium on Natural Products and Biological Activities, Keidanren, Kaikan, Japan, November 5-7, 1984 .
  • Atrial Natriuretic Factor: An Overview. de Bold, A.J. Proceedings of the 17th Annual meeting of the American Society of Nephrology, Washington D.C., December 9-12, 1984.
  • Main Forms of Immunoreactive Natriuretic Factor in Atrial Tissue and in Isolated Specific Atrial Granules. Davies, P.L., de Bold, A.J., de Bold, M.L., Flynn, T.G. and Kennedy, B.P. Can. Fed. Biol. Societies, Toronto, Ontario, June 17-21, 1985.
  • Main Forms of Immunoreactive Natriuretic Factor in Atrial Tissue and in Isolated Specific Atrial Granules. Flynn, T.G., de Bold, A.J., de Bold, M.L., Davies, P.L. and Kennedy, B.P. Biochemical Society meeting, Cardiff, Wales, March 20-22, 1985.
  • Atrial Stretch-Secretion Coupling and Immunoreactive Cardionatrin (IRC) Release In Vitro: Effect of Ca2+ and EGTA. de Bold, M.L. and de Bold, A.J. The First World Congress on Biologically Active Atrial Peptides, New York, N.Y., May 29-June 1, 1986.
  • Relation Between Atrial Specific Granules and Cardionatrin Synthesis and Storage in the Rat. Tadross, O.E., Sarda, I.R., Davies, P.L. and de Bold, A.J. The First World Congress on Biologically Active Atrial Peptides, New York, N.Y., May 29-June 1, 1986.
  • A Study on the Factors Affecting the Radioimmunoassay (RIA) of Cardionatrin (C). Sarda, I.R. and de Bold, A.J. The First World Congress on Biologically Active Atrial Peptides, New York, N.Y., May 29-June 1, 1986.
  • An Overview of Atrial Natriuretic Factor. de Bold, A.J. XXX International Congress of Physiological Sciences, Vancouver, B.C., July 13-18, 1986.
  • Factors Affecting the Release of Immunoreactive Cardionatrin (IRC) In Vitro from Human and Rat Atria. de Bold, A.J., de Bold, M.L., Taichman, G.C., Boyd, D.A. and Keon, W.J. The American Society of Hypertension World Congress on Biologically Active Atrial Peptides, New York, N.Y., May 17-21, 1987.
  • Factors Affecting Cardionatrin Release. de Bold, A.J. and de Bold, M.L. First European Congress of Endocrinology, Copenhagen, Denmark, June 21-25, 1987.
  • Ouabain Like Natriuretic Factor (OLNF) and Atrial Natriuretic Factor (ANF) in Normal Pregnancy, in Pregnancy Induced Hypertension (PIH) and in Preeclampsia (PE). Fievet, P., Fournier, A., Favre H., Roth O., Siegenthaler, G., Gregoire, I., El Esper, N., and de Bold, A.J. Xth International Congress of Nephrology, London, England, July 26-31, 1987.
  • Hemodynamic and Renal Effects of Atrial Natriuretic Factor are Attenuated in Experimental Heart Failure. Moe, G.W., Forster, C., de Bold, A.J. and Armstrong, P.W. Canadian Cardiovascular Society Annual Meeting, Edmonton, Alberta, October 28-31, 1987.
  • Pathophysiologic Role of Atrial Size and Pressure in the Modula¬tion of Plasma Natriuretic Factor During Evolving Experimental Heart Failure. Moe, G.W., Howard, R.J., Angus, C., de Bold, A.J. and Armstrong, P.W. Canadian Cardiovascular Society Annual Meeting, Edmonton, Alberta, October 28-31, 1987.
  • Functional Morphology of ANF Release. de Bold, A.J. and de Bold, M.L. UCLA Symposium: Biological and Molecular Aspects of Atrial Factors, Steamboat Springs, Colorado, January 17-23, 1988.
  • Sequential Study of Plasma Atrial Natriuretic Factor (P. ANF), Urinary Oubain-Like Natriuretic Factor (U. OLNF) and Urinary Dopamine in Normotensive Pregnant Women Before and After Delivery. Gregoire, I., El Esper, N., Fournier, A., Fievet, P., Westeel, P.F., de Bold, A.J., and Favre, H. International Congress of the International Society for the Study of Hypertension in Pregnancy, Montreal, Quebec, 1988.
  • Effects of Divalent Cations and Lanthanum on Immunoreactive Cardionatrin (IRC; ANF 99-126) Research. de Bold, M.L., and de Bold, A.J. FASEB J., 2:65, 1988.
  • Studies on Stretch - Secretion Coupling and Other Cell Properties of Atrial Cardiocytes. de Bold, A.J., and de Bold, M.L. Kyoto Symposium on ANP, Kyoto, Japan, July 15-23, 1988.
  • Atrial Natriuretic Factor: A Marker of Right Ventricular Failure During Acute Pressure Overload? Vizel, S., de Bold, A.J. and Calvin, J.E. Canadian Cardiovascular Society - Annual Meeting, October 26-29, 1988.
  • Atrial Natriuretic Factor: A Marker of Right Ventricular Failure During Acute Pressure Overload? Vizel, S., de Bold, A.J. and Calvin, J.E. American Heart Association - 61st Scientific Sessions, November 14-17, 1988.
  • Atrial Natriuretic Factor: A Marker of Right Ventricular Failure During Acute Pressure Overload? Calvin, J.E., de Bold, A.J, and Vizel, S. American College of Cardiology - 38th Annual Scientific Session, March 19-23, 1989.
  • The Effect of Catecholamines and Neurotransmitters on ANF Release. de Bold, M.L., and de Bold, A.J. 73rd Annual Meeting Federation of American Societies for Experimental Biology, New Orleans, Louisiana, March 19-23, 1989.
  • A Decade of ANF Research - Keynote Address. de Bold, A.J. Ottawa Symposium on Atrial Natriuretic Factor, "A Decade of ANF Research" International Hypertension Society Satellite Symposium, Ottawa, June 21-23, 1990
  • Plasma Concentrations of Endothelin and Atrial Natriuretic Peptide in Normal and Hypertensive Pregnancy. Westeel, P.F., Lalau, J.D., El Esper, N., Achard, J.M., Gregoire, I., Fievet, P., de Bold, A.J., and Fournier, A. 23rd Annual Meeting The American Society of Nephrology, Ottawa, Ontario, December 2-5, 1990
  • Different Gene Activation Mode for Atrial Natriuretic Factor versus Structural Heart Muscle Gene. Boer, P.H., Kuroski-de Bold, M.L., de Bold, A.J., Ottawa Symposium on Atrial Natriuretic Factor, "A Decade of ANF Research" International Hypertension Society Satellite Symposium, Ottawa, June 21-23, 1990
  • Effect of Angiotensin II, Phorbol Ester and Potassium Depolarization on ANF Release. Kuroski-de Bold, M.L., de Bold, A.J., Ottawa Symposium on Atrial Natriuretic Factor, "A Decade of ANF Release" International Hypertension Society Satellite Symposium, Ottawa, June 21-23, 1990, p 14
  • Endothelin (ET) - Induced Atrial Natriuretic Factor (ANF) Release: Modulation by Calcium. de Bold, A.J., and Kuroski-de Bold, M.L., FASEB J. Part I: A289, 1990
  • Studies on Basal and Stretch-Induced Atrial Natriuretic Factor (ANF) Release. Kuroski-de Bold, M.L., de Bold, A.J., FASEB J. Part I: A289, 1990
  • Presence of Stretch-Activated Channels in Freshly Isolated Adult Rat Heart Cells. Bustamante, J.O., de Bold M.L., Boer P.H., and de Bold A.J. J Cell Biochem Suppl 15C:167, 1991
  • Different Gene Activation Mode for Atrial Natriuretic Factor versus Structural Heart Muscle Genes. P.H. Boer, M.L. de Bold, and A.J. de Bold. J Cell Biochem Suppl 15C: 160, 1991
  • Studies on ANF Processing and Release from Adult Rat Cardiocytes on Microcarrier Beads. G.R. Dubé, M.L. Kuroski-de Bold, A.J. de Bold. FASEB J Pt. II:A1021,1991
  • Activation Mode of the Atrial Natriuretic Factor Gene During P19 Cardiac Myogenesis. Boer, P.H., de Bold, M.L., de Bold, A.J., Bustamante, J.O. FASEB J Pt. II:A1748, 1991
  • Natriuretic Peptide storage and Release by Atrial Cardiomyocytes. Kuroski-de Bold, M.L. and de Bold, A.J. Proc. 1991 USCD Asilomar Conference "Molecular and Cellular Biology of the Cardiac Myocyte"
  • Activation of Atrial Natriuretic Factor Genes Types -A and -B but not -C during P-19 Cardiac Muscle Differentiation. Boer, P.H. and de Bold, A.J. Proc. 1991 USCD Asilomar Conference "Molecular and Cellular Biology of the Cardiac Myocyte"
  • Plasma Concentrations of Endothelin and Atrial Natriuretic Peptide in Normal and Hypertensive Pregnancy. Westeel P.F., Lalau J.D., El Esper N., Achard J.M., Gregoire I., Fievet P., de Bold A., Fournier A. Ottawa Symposium on Atrial Natriuretic Factor, "A Decade of ANF Research" International Hypertension Society Satellite Symposium, Ottawa, June 21-23, 1990
  • Endothelin and Atrial Natriuretic Factor Levels Vary with CHF Severity. E.R. O'Brien, T.D. Ruddy, R.A. Sochowski, S.A. Kearns, A.J. de Bold. Can. J. Cardiol l.7: 104A, 1991
  • Relationship of Endothelin to Symptoms and Hemodynamics in Congestive Heart Failure. O'Brien, Ruddy, T.D., Sochowski, R.A., Kearns, S.A., de Bold, A.J. J. Am. Coll. Cardiol. 17: A, 1991
  • Effect of Renal Endopeptidase Inhibition on Sodium Excretion and Renal Hemodynamics in Heart Failure. C.D. Kimmelstiel, R.D. Perrone, L. Kilcoyne, J. E. Udelson, J. J. Smith, A. J. de Bold, E. Henry, J. F. Souhrada, M. A. Konstam. Am. Coll. Cardiol. 19: 146A, 1992
  • Endothelin Levels Following PTCA of the Left Anterior Descending Coronary Artery. M. Labinaz, T.D. Ruddy, J.F. Marquis, S.A. Kearns, M.R. LeMay, L.A. Higginson, B.P. Moran, A.J. de Bold, Can . J. Cardiol. 8:109B, 1992
  • Morphological and Biochemical Studies on The Subcellular Distribution of A- and B- Type Natriuretic Factors in the Rat Heart. M. Kuroski-de Bold, O. Pulido, G. Dubé, B. Fernandez, and A.J. de Bold. Faseb J. Pt. I:A1234, 1992
  • The Release of Newly Synthesised and Stored ANF under Basal and Stimulated Conditions. Mangat, H. and de Bold, A.J. FASEB J. 7: A670, 1993
  • Temporal Pattern of Expression of Myosin Heavy Chain, ANF and BNF in Monoculture and Co-Culture of Adult Rat Ventricular Myocites with Epicardial Mesothelial Cells. Eid, H., Chen, J.H., Kuroski-de Bold, M.L. and de Bold, A.J. J.Cell Biochem. Supp. 17D: 210, 1993
  • Effects of HS-142-1 (HS), an Antagonist of Natriuretic Peptide (NP) Bioactive Receptors, on Deoxycorticosterone Acetate (DOCA) Escape. Yokota, N., Kuroski-de Bold, M.L., and de Bold, A.J. J.Am.Soc.Nephrol. 4: 450, 1993
  • Transcriptional and Post-Translational Regulation of Atrial Natriuretic Factor (ANF) and Brain Natriuretic Peptide (BNP) During the Development of DOCA-Salt Hypertension. Yokota, N., de Bold, M. L. and de Bold, A.J. Circulation 88:I-315, 1993
  • Natriuretic Peptide and Early Response Gene Expression in Isolated Rat Atria Following Stimulation by Stretch or Endothelin-1. Bruneau, B. and de Bold, A.J. Am.J.Hypertens. 7 (4, ptII): 79A, 1994
  • Regulation of Alpha-Smooth Muscle Actin Expression in Adult Cardiomyocytes Through A Tyrosine Kinase Signal Transduction Pathway. Eid, H., Chen, J.H. and de Bold,A.J.
  • Proceedings of the International Workshop on Myocardial Growth and Regeneration. NATO Advanced Research Workshop. Viterbo, Italy, 1994
  • α1-Adrenergic Stimulation of Natriuretic Peptide Secretion and Gene Expression in Isolated Right atria. Bruneau, B.G., Piazza, L.A. and de Bold, A.J. J.Molec.Cell .Cardiol., 27: A242, 1995
  • Natriuretic Peptide Production in Hypertensive rats With or Without Cardiac Hypertrophy. Ogawa, T., Linz, W., Stevenson, M., Bruneau, B.G., Kuroski-de Bold, M.L. and de Bold, A.J. J.Molec.Cell.Cardiol. 27:A219, 1995
  • Natriuretic Peptide Production in Hypertensive rats With or Without Cardiac Hypertrophy. Ogawa, T., Linz, W., Stevenson, M., Bruneau, B.G., Kuroski-de Bold, M.L. and de Bold, A.J. Can.J.Cardiol. 11: 128E, 1995.
  • Characterization of the Cardiac Conducting System in the Rat and Monkey (Macaca fascicularis) by Immunohistochemistry. Mueller, R., Pulido, O. Kuroski de Bold, M.L., Luus, L., Rowsell, P., Smyth, P., Langlois, I., de Bold, A.J. FASEB J. 9: A374, 1995
  • Regulation of Brain Natriuretic Peptide (BNP) in Male and Female Spontaneously Hypertensive Rats. Kuroski de Bold, M.L. and de Bold, A.J. FASEB J. 9:A78, 1995
  • Natriuretic peptide production in hypertensive rats with or without cardiac hypertrophy. Ogawa, T., Linz, W., Stevenson, M., Bruneau, B.G., Kuroski-de Bold, M.L. and de Bold, A.J. Am. J. Hyperten. 9: 8A, 1996
  • Specific Changes In Translational, Postranslational, Storage And Release Events Associated With Various Mechanical And Neuroendocrine Stimuli Of Cardiac Natriuretic (NP) Production. de Bold, A.J. Proceedings of the 29th Assembée Annuelle, Union des Societés Suisses de Biologie Expérimentale, page A31, 1997.
  • Effect of Chronic Endothelin-1 (ET-1) Receptor (ET-1A) blockade on Natriuretic Peptide Gene Expression in Doca-Salt Hypertension" Bianciotti, L. and de Bold, A.J. 51th Annual Meeting of the Canadian Cardiovascular Society, Ottawa, October 23 1998.
  • Physiological Roles of Natriuretic Peptides (NP). de Bold, A.J. 1st International Symposium of Cardiovascular Endocrinology and Metabolism. Kyoto, November 27-28, 1998
  • Strategies on competing in science and technology. de Bold, A.J. 1st Symposium on Teaching in Science and New Technologies. International Book Fair, Sponsorship by the Canadian Embassy in Buenos Aires, April 1999
  • Natriuretic peptides: ubiquitous modulators of cardiovascular function and growth. de Bold, A.J. VI Meeting of the International Society for Heart Research. Latin American Section, and XVIII National Congress of Cardiology, Buenos Aires, May 1999.
  • Natriuretic peptides as cardiovascular sentries. Clinical use of plasma levels. de Bold, A.J. VI Meeting of the International Society for Heart Research. Latin American Section, and XVIII National Congress of Cardiology, Buenos Aires, May 1999.
  • Disruption of the Ventricle-Specific Homeobox Gene Irx4 in Mice Leads to Cardiac Dysfunction and Hypertrophy. Bruneau,B.G., Bao,Z-Z-, Fatkin, D., Georgakopoulos, D., Mudd, J.O., Conner, D.A., Schoen, F.J., de Bold, A.J., Cepko, C.L., Seidman, J.G. and Seidman C.E. Circulation 100 (Suppl 1), I347-348, 1999
  • Effect of Chronic Endothelin-1 (ET-1) Receptor (ET-1A) blockade on Natriuretic Peptide Gene Expression in Doca-Salt Hypertension. Bianciotti, L. and de Bold, A.J. J.Molec.Cell.Cardiol. 32:A34, 2000
  • Role of Gi/o-Protein Signalling in ANF Stretch-Secretion Coupling In Heart Atria. Bensimon, M.A. and de Bold, A.J. J.Molec.Cell.Cardiol. 33: A11, 2001
  • Pro-Inflammatory Cytokines Specifically Upregulate BNP Expression. Ma, K-Y and de Bold, A.J. J.Molec.Cell.Cardiol. 33: A70, 2001
  • Molecular basis for the altered secretion of the cardiac natriuretic peptides ANF and BNP during human acute cardiac allograft rejection. Ma, KK and de Bold, AJ. Transplantation. 27:S545, 2002
  • Expression and secretion of BNP is selectively upregulated by pro-inflammatory cytokines. Ma, Kenneth K-Y., and de Bold, Adolfo J. Abstract P2-589. Endocrine Society 85th Annual meeting. Philadelphia. USA. 2003
  • Molecular Basis for the Altered Secretion of the Cardiac Natriuretic Peptides ANF and BNP During Human Acute Cardiac Allograft Rejection. Ma, Kenneth K-Y., and de Bold, Adolfo J. Transplantation 27;74(4):545, 2003
  • Brain Natriuretic Peptide (BNP) as a Guideline to β-Blocker Titration in Patients
  • with Heart Failure. Luis Beck da Silva, Adolfo de Bold, Margaret Fraser, Kathryn Williams, Christine Struthers, Haissam Haddad, Heart Failure Society of America Proceedings, S101, #377, 2003
  • Phosphoplipase C inhibitors increase atrial natriuretic factor secretion. Chang AI, de Bold AJ. FASEB J. Part II:A1246, 2004
  • Cardiac Hormones and Inflammation. De Bold, A.J. Proceedings of the 16th World Congress of Cardiothoracic Surgeons, Ottawa, Ontario. August 16-18, 2006
  • Inflammation and the endocrine Heart. de Bold, A.J. Proceedings of the Fifth Oulu Symposium on "Advances in Molecular and Cellular Biology of Vasoactive Factors" Finland, September 9, 2006
  • Protein-Protein Interactions between an Atrial-Specific Go Protein and Secretory Products in the Vectorial Transport and Secretion of Natriuretic Peptides. de Bold, A.J., Ogawa T., Forero, M., Burgon, P., de Bold, M.L., Georgalis, T. Proceedings of the International Congress on Vasoactive Peptides. Ouro Preto, MG, Brazil, February 2008
  • Cardiac Natriuretic Peptides Gene Expression and Secretion in Inflammation. de Bold, A.J. Cardiac hormones: For the Treatment of Acute Myocardial Infarctions, Congestive Heart Failure, Acute Renal Failure and Cancer. EB 2008, San Diego, April 9, 2008

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