Marcel, Yves


Dr. Yves Marcel was Director of the HDL Biology Laboratory at the University of Ottawa Heart Institute. He was also a cross-appointed Professor in the Department of Pathology and Laboratory Medicine and the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa.


Marcel earned his first degree in Science at the Université de Rouen. In 1961, he obtained a diploma in Chemical Engineering from the Ecole Nationale Supérieure de Chimie de Toulouse and one in Chemistry and Physics from the Université de Toulouse. That year he joined the Faculty of Medicine at the Université de Toulouse as a Biochemistry Assistant.

After completing his Doctorate in Biochemistry in 1965, he worked for two years as a Research Fellow at Hormel Institute at the University of Minnesota. Two years later, he served as Assistant Professor in the Department of Medicine and Senior Scientist in the Clinical Research Institute at the Université de Montréal. He became Director of the Laboratory of Lipoprotein Metabolism in 1973, serving in this role for 19 years. He also held the position of Professor in the Department of Medicine. Marcel became Associate Member of the Department of Experimental Medicine at McGill University in Montreal in 1981.

Since 1992, he has also been Director of the Atherosclerosis, Genetics and Cell Biology Lab, formerly know as the Lipoprotein and Metabolism Laboratory . Marcel also served as Chief Scientific Officer and Vice President of Research for the Heart Institute until 2003.

Yves Marcel was awarded the Royal Society of Canada’s McLaughlin Medal in 1997 and the Ottawa Life Sciences Basic Research Award in 2001.

Research & Clinical Interests 

Yves Marcel’s areas of expertise and interests include HDL, apolipoprotein A-I structure, and reverse cholesterol transport; apolipoprotein E (apoE) association with cell matrix elements of the hepatocyte; and the nature and role of the cell surface apoE in lipoprotein metabolism.



  • Ouimet M, FranklinV, Mak E, Liao X, Tabas I, Marcel YL. ‘Autophagy RegulatesCholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase. Cell Metabolism, 2011 13(6):655-67
  • Marcel YL, Ouimet M, Wang M-D. Cellular lipid traffic and lipid transporters: regulation of efflux and HDL formation. In Cellular Lipid Metabolism, C. Ehnholm, Ed. Springer. Pg 73-106, 2009.
  • Marcel YL, Ouimet M, Wang M-D. Regulation of lipid efflux in macrophages. Current Opinion in Lipidology 2008;19(5):455-461.
  • Marcel YL, Ouimet M, Wang M-D. Regulation of cholesterol efflux in macrophages. Curr Opin Lipidol 2008;(19):455-461.
  • Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. Arterioscler Thromb Vasc Biol 2008 Jun;28(6):1144-1150. Epub 2008 Mar 27. PMID: 18369155 [PubMed: indexed for MEDLINE].

Papers in Refereed Journals

  • MARCEL, Y.L., McPHERSON, R., HOGUE, M., CZARNECKA, H., ZAWADZKI, Z., WEECH, P.K., WHITLOCK, M.E., TALL, A.R. and MILNE, R.W. (1990). Distribution and Concentration of Cholesteryl Ester Transfer Protein in Plasma of Normolipemic Subjects. J. Clin. Invest. 85, 10-17.
  • PEASE, R.J., MILNE, R.W., JESSUP, W.K., LAW, A., PROVOST, P., FRUCHART, J.-C., DEAN, R.T., MARCEL, Y.L. and SCOTT, J. (1990). Use of Bacterial Expression Cloning to Localize the Epitopes for a Series of Monoclonal Antibodies against Apoliprotein B100. J. Biol. Chem. 265(1), 553-568.
  • QUINET, E.M., AGELLON, L.B., KROON, P.A., MARCEL, Y.L., LEE, Y.-C., WHITLOCK, M.E. and TALL, A.R. (1990). Atherogenic Diet Increases Cholesteryl Ester Transfer Protein Messenger RNA Levels in Rabbit Liver. J. Clin. Invest. 85(2), 357-363.
  • PROVOST, P.R., WEECH, P.K., TREMBLAY, N.M., MARCEL, Y.L. and RASSART, E. (1990). Molecular characterization and differential mRNA tissue distribution of rabbit apolipoprotein D. J. Lipid Res. 31(11), 2057-2065.
  • LEVY, E., ROCHETTE, C., LONDONO, I., ROY, C.C., MILNE, R.W., MARCEL, Y.L. and BENDAYAN, M. (1990). Apolipoprotein B-100: immunolocalization and synthesis in human intestinal mucosa. J. Lipid Res. 31(11), 1937-1946.
  • CHATTERTON, J.E., PHILLIPS, M.L., CURTISS, L.K., MILNE, R.W., MARCEL, Y.L. and SCHUMAKER, V.N. (1991). Mapping apolipoprotein B on the low density lipoprotein surface by immunoelectron microscopy. J. Biol. Chem. 266, 5955-5962.
  • LEBLOND, L. and MARCEL, Y.L. (1991). The amphipathic ÿ-helical repeats of apolipoprotein A-I are responsible for binding of high density lipoproteins to HepG2 cells. J. Biol. Chem. 266, 6058-6067.
  • MARCEL, Y.L., PROVOST, P.R., KOA, H., RAFFAI, E., DAC, N.V., FRUCHART, J.-C. and RASSART, E. (1991). The epitopes of apolipoprotein (apo) A-I define distinct structural domains including a mobile middle region. J. Biol. Chem. 266(6), 3644-3653.
  • McPHERSON, R., HOGUE, M., MILNE, R.W., TALL, A.R. and MARCEL, Y.L. (1991). Increase in plasma cholesteryl ester transfer protein during probucol treatment: Relation to changes in high density lipoprotein composition. Arteriosclerosis and Thrombosis, 11, 476-481.
  • ZAWADZKI, Z., MILNE, R.W. and MARCEL, Y.L. (1991). Cu2+-mediated oxidation of dialized plasma: Effects on low and high density lipoproteins and cholesteryl ester transfer protein. J. Lipid Res. 32, 243-250.
  • COLLET, X., PERRET, B., SIMARD, G., RAFFAI, E. and MARCEL, Y.L. (1991). Differential effects of lecithin and cholesterol on the immunoreactivity and conformation of apolipoprotein A-I in high density lipoproteins. J. Biol. Chem. 266(14), 9145-9152.
  • Mcpherson, R., MANN, C.J., TALL, A.R., HOGUE, M., MARTIN, L., MILNE, R.W. and Marcel, Y.L. (1991). Plasma concentrations of cholesteryl ester transfer protein (CETP) in hyperlipoproteinemia: Relation to cholesteryl ester transfer protein activity and other lipoprotein variables. Arteriosclerosis and Thrombosis 11, 797-804.
  • L. Brissette, N. Cahuzac, M. Desforges, J.-L. Bec, Milne, R., Marcel, Y.L. and Rassart, E. (1991). Expression and purification of recombinant human apolipoprotein A-I from Chinese hamster ovary cells or E. Coli. Protein Expression and Purification, 2, 296-303.
  • Provost, P.R., Villeneuve, L., Weech, P.K., Milne, R.W., Marcel, Y.L. and Rassart, E. (1991) Localization of the major sites of rabbit apolipoprotein D gene transcription by in situ hybridization. J. Lipid Res., 32, 1959-1970.
  • Provost, P., Marcel, Y.L., Milne, R.W., Weech, P.K. and Rassart, E. (1991) Apolipoprotein D transcription occurs specifically in nonproliferating quiescent and senescent fibroblast cultures. FEBS Letters 290, 139-141.
  • Hannuksela, M., Marcel, Y.L., Kesaniemi, A. and Savolainen, M.J. (1992) Reduction in the mass activity of plasma cholesteryl ester transfer protein by alcohol. J. Lipid Res., 33, 737-744.
  • Martin, L., Connelly, P., Nancoo, D., Wood, N., Zhang, Z.J., Maguire, G., Quinet, E., Tall, Al., Marcel, Y. and McPHERSON, R. (1993) Cholesteryl ester transfer protein and high density lipoprotein responses to cholesterol feeding in man: Relationship to Apolipoprotein E genotype. J. Lipid Res. 34:437-446.
  • Leblond, L. and Marcel, Y.L. (1993) Uptake of HDL cholesterol ester by HepG2 cells involves apolipoprotein E localized on the cell surface. J. Biol. Chem. 268, 1670-1676.
  • Lambert, J., Provost, P.R., Marcel, Y.L. and Rassart, E. (1993) Structure of the human apolipoprotein D gene promoter region. Biochim. Biophys. Acta 1172, 190-192
  • Quinet, E.M., Huerta, P., Nancoo, D., Tall, A.R. Marcel, Y.L., and Mcpherson, R. (1993). Adipose tissue cholesteryl ester transfer mRNA in response to probucol: Cholesterol and species dependence. J. Lipid Research 34, 845-852.
  • Agnani, G. and Marcel, Y.L. (1993) Cholesterol efflux from fibroblasts to discoïdal lipoproteins with apolipoprotein A-I (LpA-I) increases with particle size but cholesterol transfer from LpA-I to lipoproteins decreases with size. Biochemistry 32, 2643-2649.
  • Calabresi, L., Meng, Q.-H., Castro, G.R., and Marcel, Y.L. (1993) Apolipoprotein A-I conformation in discoïdal particles: Evidence for alternate structures. Biochemistry 32, 6477-6484.
  • Meng, Q.-H., Calabresi, L., Fruchart, J.-C. and Marcel, Y.L. (1993) Apolipoprotein A-I domains involved in the activation of lecithin-cholesterol acyltransferase. Evidence for a hinged double helix domain. J. Biol. Chem. 268, 16966-16973.
  • Cohn, J.S., Johnson, E.J., Millar, J.S., Cohn, S.D., Milne, R.W., Marcel, Y.L., Russell, R.M. and Schaefer, E.J. (1993) Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J. Lipid Research 34, 2033-2040.
  • Linga, V., Leight, M.A., Curtiss, L.K., Marcel, Y.L., St. Clair, R.W., and Parks, J.S. (1994). Dietary fish oil-induced decrease in low density lipoprotein binding to fibroblasts is mediated by apolipoprotein E. J. Lipid Research 35, 491-500.
  • Galeano, N.F., Milne, R., Marcel, Y.L., Walsh, M.T., Levy, E., Ngu'yen, T-D, Gleeson, A., Arad, Y., Witte, L, Al-Haideri, M., Rumsey, S.C., and Deckelbaum, R.J. (1994). Apoprotein B structure and receptor recognition of triglyceride-rich low density lipoprotein (LDL) is modified in small LDL but not in triglyercide-rich LDL of normal size. J. Biol. Chem. 269, 511-519.
  • Meng, Q-H., Sparks, D.L. and Marcel, Y.L. (1995). Effect of LpA-I composition and structure on the cholesterol transfer between lipoproteins. J. Biol. Chem. 270, 4280-4287.
  • Meng, Q-H., Bergeron, J., Sparks, D.L. and Marcel, Y.L. (1995). Role of apolipoprotein A-I in cholesterol transfer between lipoproteins: Evidence for involvement of specific apoA-I domains. J. Biol. Chem. 270, 8588-8596.
  • Saxena, U., Auerbach, B.J., Ferguson, E., Wolle, J., Marcel, Y.M., Weisgraber, K.H., Hegele, R.A., and Bisgaier, C.L. (1995). Apolipoprotein B and E basic amino acid clusters with lipoprotein lipase anchored to the subendothelial matrix. Arterio. Throm. & Vas. Biology 15(8), 1240-1247.
  • Bergeron, J., Frank, P., Scales, D., Meng, Q-H., Castro, G., and Marcel, Y.L. (1995). Apoliproprotein A-I conformation in reconstituted discoidal lipoproteins varying in phospholipid and cholesterol content. J. Biol. Chem. 270, 27429-27438.
  • Zhao, Y. and Marcel, Y.L. (1996). Serum albumin is a significant intermediate in cholesterol transfer between cells and lipoproteins. Biochemistry, 35, 7174-7180.
  • Zhao, Y., Sparks, D.L. and Marcel, Y.L. (1996). Specific phospholipid association with apolipoprotein A-I stimulates cholesterol efflux from human fibroblasts: Studies with reconstituted sonicated lipoproteins. J. Biol. Chem. 271, 25145-25151.
  • Zhao, Y., Sparks, D.L. and Marcel, Y.L. (1996). The effect of the apolipoprotein A-I and surface lipid composition of reconstituted discoidal HDL on cholesterol efflux from cultured fibroblasts. Biochemistry 35, 16510-16518.
  • Mcpherson, R., Agnani, G., Lau, P., Fruchart, J-C., Edgar, A.D. and Mar cel Y.L. (1996). Role of LpA-I and LpA-I/A-II in cholesteryl ester transfer protein- mediated neutral lipid transfer. Arteriosclerosis, Thrombosis and Vascular Biology 16, 1340-1346.
  • Bergeron, J., Frank, P.G., Emmanuel, F., Latta, M., Zhao, Y., Sparks, D.L., Rassart, E., Denefle, P., and Marcel, Y.L. (1997). Characterization of human apolipoprotein A-I expressed in escherichia coli. Biochim. et Biophy. Acta. 1344, 139-152.
  • Frank, P.G., Bergeron, J., Emmanuel, F., Lavigne, J-P., Sparks, D.L., Denefle, P., Rassart, E., and Marcel, Y.L. (1997) Deletion of central ÿ-helices in human apolipoprotein A-I: Effect on phospholipid association. Biochemistry 36, 1798-1806.
  • Collet, X., Marcel, Y.L., Tremblay, N., Lazure, C., Milne, R.W., Perret, B. and Weech, P.K. (1997). Evolution of mammalian apolipoprotein A-I and conservation of antigenicity. Correlation with primary and secondary structure. J. Lipid Res. 38, 634-644.
  • Pussinen, P.J., Jauhiainen, M., Metso, J., Pyle, L.E., Marcel, Y.L., Fidge, N.H., and Ehnholm, C. (1998). Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: Location of a PLTP binding domain in the amino terminal region of apoA-I. J. Lipid Res. 39, 152-161.
  • Burgess, J.W., Gould, D.R. and Marcel, Y.L. (1998). The HepG2 extracellular matrix contains separate heparinase- and lipid-releasable pools of apoE. J. Biol. Chem. 273, 5645-5654.
  • Frank, P.G., N'guyen, D., Franklin, V., Neville, T., Desforges, M., Rossart, E., Sparks, D.L., and Marcel, Y.L. (1998). Importance of central ÿ-helices of human apolipoprotein A-I in the maturation of light density lipoproteins. Biochemistry 37, 13902-13909.
  • Burgess, J.W., Liang, P., Vaidyanath, C. and Marcel, Y.L (1999). ApoE of HepG2 cell surface includes a major pool associated with chondroitin sulfate proteoglycans. Biochemistry 38, 524-531.
  • Sparks, D. L., Frank, P., Braschi, S., Neville, T. and Marcel, Y. L. (1999). The effect of apolipoprotein A-I lipidation on the formation and function of pre- and -migrating LpA-I particles. Biochemistry 38, 1727-1735.
  • Guendouzi, K., Jaspard, B. Barbaras, R., Motta, C., Vieu, C., Marcel, Y. L., Chap, H., Perret, B. and Collet, X. (1999). Biochemical and physical properties of remnant HDL2 and of preÿ1-HDL produced by hepatic lipase. Biochemistry 38, 2762-2768.
  • Moreau, R., Frank, P. G., Perreault, C., Marcel, Y. L., and Manjunath, P. (1999). Seminal plasma choline phospholipid-binding proteins stimulate cellular cholesterol and phospholipid efflux. Biochim. Biophys. Acta. 438, 38-46.
  • Frank, P.G.#, Burgess, J.W.#, McManus, D.C., Franklin, V., Desforges, M., Rassart, E. and Marcel, Y.L. (1999). Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage. Biochemistry 38, 14524-14533. # Co-first authors.
  • McManus, D.C. , Scott, B.R., Frank, P.G., Franklin,V. Schultz, J.R., and Marcel, Y.L. (2000) Distinct Central Amphipathic ÿ-Helices in Apolipoprotein A-I Contribute to the in Vivo Maturation of High Density Lipoprotein by Either Activating Lecithin: Cholesterol Acyltransferase or Binding Lipids. J. Biol. Chem. 275, 5043-5051.
  • Frank, P.G., and Marcel, Y. L. (2000) Apolipoprotein A-I: Structure Function Analysis. J. Lipid Res., 41, 853-872.
  • Okon, M. Marcel, Y. L., Frank, P.G., and Cushley, R.J. (2001) Secondary Structure of apoA-I (1-186) in lipid-mimetic solution. FEBS Letters, 487, 390-396.
  • Frank, P.G., Galbiati, F., Volante, D., Razani, B., Cohen, D., Marcel, Y. L., and Lisanti, M.P. (2001) Influences of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins. Am. J. Physical Cell Physiol., 280, C1204-C1214
  • McManus, D.C.#, Scott, B.R.#, Franklin, V. and Marcel, Y. L. (2001) Proteolytic degradation and impaired secretion of an apolipoprotein A-I mutant associated with dominantly inherited hypoalphalipoproteinemia. J. Biol. Chem., 276, 21292-21302. # co-first authors.
  • Calabresi, L., Tedeschi, G., Treu, C., Ronchi, S., Galbiati, F., Airoldi, S., Sirtori, C.R., Marcel, Y. L. and Franceschini, G. (2001) Limited proteolysis of a disulfide-linked apoA-I dimer in reconstituted HDL. J. Lipid Res., 42, 935-942.
  • Yuhanna, I.S., Zhu, Y., Cox, B.E., Hahner, L.D., Osborne-Lawrence, S., Lu, P., Marcel, Y. L., Anderson, R.G.W., Mendelsohn, M.E., Hobbs, H.H., and Shaul, P.W. (2001) High density lipoprotein binding to scavenger receptor-BI activates endothelial mitric oxide synthase. Nature Medicine, 7, 853-857.
  • Burgess, J.W., and Marcel, Y. L. (2001) Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface. J. Lipid Res., 42, 1413-1420.
  • Scott, B.R., McManus, D.C., Franklin, V., McKenzie, A. G., Neville, T., Sparks, D.L. and Marcel, Y. L. (2001) The N-terminal Globular Domain and the First Class A amphipathic Helix of apolipoprotein A-I are important for LCAT activation and the maturation of HDL In Vivo. J. Biol. Chem, 276, 48716-48724.
  • Burgess, J.W., Kiss, R.S., Zheng, H., Zachariah, S. and Marcel, Y. L. (2002) Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. J. Biol. Chem, 277, 31318-31326.
  • Okon, M., Frank, P.G., Marcel, Y.L., Cushley, R.J. (2002) Heteronuclear NMR studies of human serum apolipoprotein A-I. Part I. Secondary structure in lipid-mimetic solution. FEBS Letters, 517, 139-143.
  • Frank, P.G., Marcel,Y.L., Connelly, M.A., Lublin, D.M., Franklin, V., Williams, D.L., and Lisanti, M.P. (2002) Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor-class B type I. Biochemistry 41, 11931-11940.
  • Kiss, R.S., McManus, D.C., Franklin, V., Tan, W.L., McKenzie, A., Chimini, G., and Marcel, Y.L. (2003) The lipidation by hepatocytes of human apolipoprotein A-I occurs by both ABCA1 dependent and independent pathways. J. Biol. Chem. 278, 10119-10121.
  • Cohen, J.C.*#, Kiss, R.S.*, Pertsemlidis, A., Marcel, Y.L.#, McPherson, R., Hobbs, H.H. (2004) Multiple rare alleles contribute to low plasma HDL cholesterol. Science, 305(5685) 869-72. (* co-first authors, #co-corresponding authors).
  • Assanasen, C. , Mineo, C., Seetharam, D., Yuhanna, I. S., Marcel, Y.L., Connelly, M. A., Williams, D.L., de la Llera-Moya, M., Shaul, P.W., and Silver, D.L. (2005) Cholesterol Binding, Efflux and a PDZ-interacting Domain of SR-BI Mediate HDL-Initiated Signaling. J. Clin. Invest. 115: 969-977.
  • Zheng, H., Kiss, R.S., Franklin, V., Wang, M.-D., Haidar, B. And Marcel, Y.L. (2005) ApoA-I lipidation in primary mouse hepatocytes: Separate controls for phospholipid and cholesterol transfers. J Biol Chem. 280(22):21612-21. Epub 2005 Mar 29.
  • Kiss, R.S., Maric, J. and Marcel, Y.L. (2005) Modulation of lipid efflux activity in human and mice macrophage. J Lipid Res. 46(9):1877-1887. Epub 2005 Jul 1
  • Maric, J., Kiss, R.S., Franklin, V., and Marcel, Y.L. (2005) Intracellular Lipidation of Newly Synthesized Apolipoprotein A-I in Primary Murine Hepatocytes. J. Biol. Chem. 280(48):39942-9. Epub 2005 Oct 4.
  • Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW. (2006) High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res.Jan 6;98(1):63-72. Epub 2005 Dec 8.
  • Kiss RS, Ma Z, Nakada-Tsukui K, Brugnera E, Vassiliou G, McBride HM, Ravichandran KS#, Marcel YL#.(2006)The LRP adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux. J. Biol. Chem. 2006 Feb 22; [Epub ahead of print] #co-corresponding authors.
  • Kiss RS, Elliott MR, Ma Z, Marcel YL, Ravichandran KS.Apoptotic cells induce a phosphatidylserine-dependent homeostatic response from phagocytes. Curr Biol. 2006 Nov 21;16(22):2252-8.
  • Haidar B, Kiss RS, Sarov-Blat L, Brunet R, Harder C, McPherson R, Marcel YL.Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux. J Biol Chem. 2006 Dec 29;281(52):39971-81. Epub 2006 Oct 10.
  • Wang MD, Franklin V, Sundaram M, Kiss RS, Ho K, Gallant M, Marcel YL.Differential regulation of ATP binding cassette protein A1 expression and ApoA-I lipidation by Niemann-Pick type C1 in murine hepatocytes and macrophages. J Biol Chem. 2007 Aug 3;282(31):22525-33. Epub 2007 Jun 5.
  • Wang MD, Franklin V, Marcel YL.In vivo reverse cholesterol transport from macrophages lacking ABCA1 expression is impaired. Arterioscler Thromb Vasc Biol. 2007 Aug;27(8):1837-42. Epub 2007 May 31.
  • Sarov-Blat L, Kiss RS, Haidar B, Kavaslar N, Jaye M, Bertiaux M, Steplewski K, Hurle MR, Sprecher D, McPherson R, Marcel YL.Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1115-22. Epub 2007 Feb 22.
  • Kiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL.Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1139-45. Epub 2007 Feb 15.
  • Wang MD, Kiss RS, Franklin V, McBride HM, Whitman SC, Marcel YL.Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res. 2007 Mar;48(3): 633-45. Epub 2006 Dec 5.
  • Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL.Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1144-50. Epub 2008 Mar 27. PMID: 18369155 [PubMed - indexed for MEDLINE]
  • Marcel YL, Ouimet M, Wang M-D Regulation of cholesterol efflux in macrophages. Curr. Opin. Lipidol. 2008, 19: 455-461.
  • MARCEL, YL, OUIMET, M, and WANG, MD (2008) Regulation of lipid efflux in macrophages. Current Opinion in Lipidology, 19(5):455-61.

Book Chapters

  • DAVIGNON, J. and MARCEL, Y. L. Lipid metabolism of the lesion and interaction of lipoproteins with cells. In: Vascular Injury and Atherosclerosis, Sean Moore, ed., Marcel Dekker, New York. 1981, 175-207.
  • MARCEL, Y.L. Lecithin:Cholesterol Acyltransferase and Intravascular Cholesterol Transport. In: Advances in Lipid Research, vol. 19, Kritchevsky and Paoletti, eds., Academic Press, New York, 1982, 85-136.
  • MARCEL, Y. L. and WEECH, P. K. Isoelectric Focusing of Plasma Lipoproteins. In: Methods in Enzymology J.P. Segrest and J.J. Albers, eds., 128, Academic Press, New York, 1986 432-441.
  • MILNE, R. W. and MARCEL, Y. L. The use of monoclonal antibodies to probe human apolipoprotein B structure and function. In: Can. J. Biochem. Cell Biol., 63, 906-912 (1985).
  • MARCEL, Y.L., WEECH, P.K., MILTHORP, P., TERCE, F., VEZINA, C. and MILNE, R.W. Monoclonal antibodies and the characterization of apolipoprotein structure and function in Progress in Lipid Research, R.T. Holman, ed., 1986, vol. 23, pp. 169-195, Pergamon Press, Oxford. MANJUNATH, P., BAILLARGEON, L.,
  • MARCEL, Y.L., SEIDAH, N.G., CHRETIEN, M. and CHAPDELAINE, A. Diversity of novel proteins in gonadal fluids. In: Molecular Biology of Brain and Endocrine Peptidergic Systems, McKerns, K.W. and Chrétien, M. eds, pp. 259-273, Plenum Press, N.Y. 1988.
  • MARCEL, Y.L., COLLET, X., RAFFAI, E., JEWER, D., WEECH, P.K., DAC, N.V., FRUCHART, J.-C., PERRET, B., PROVOST, P. and RASSART, E. Expression of apolipoprotein A-I epitopes. Effect of proteins and lipids. In: Biotechnology of Dyslipoproteinemias: Applications in Diagnosis and Control. Lenfant C., Albertini A., Paoletti R. and Catapano A.L., eds. Raven Press, NY, volume 20, pp. 227-232.
  • MARCEL, Y.L., TALL, A.R., HOGUE, M., MILNE, R.W. and McPHERSON, R. (1990) Plasma Lipoprotein Phenotype in response to cholesteryl ester transfer protein levels in dislipoproteinemia. In: Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, eds. C.L. Malmendier et al., Plenum Press, New York, pp. 77-80. MARCEL, Y.L., TALL, A.R., HOGUE, M., MILNE, R.W., MCPHERSON, R. (1991) Plasma lipoprotein phenotype in response to cholesteryl ester transfer protein levels in dyslipoproteinemia. Adv. Exp. Med. Biol. 285, 77-80.
  • MCPHERSON, R. and MARCEL, Y.L. (1991) Role of cholesteryl transfer protein in reverse cholesterol transport. Clin. Cardiol. 14 (supp), I31-34.
  • MILNE, R.W., WEECH, P.K. and MARCEL, Y.L. (1992) Immunological methods for studying and quantifying lipoproteins and apolipoproteins. In: Lipoprotein Analysis: A practical approach, eds. Converse, C.A. and Skinner, E.R. Oxford University Press, Oxford, pp. 61-84.
  • MARCEL, Y.L., CALABRESI, L., and MENG, Q.-H. (1992) Apolipoprotein A-I: structure, lipid interaction and activation of lecithin-cholesterol acyltransferase. IN: Proceedings of 3rd International Symposium on Plasma High Density Lipoproteins and Atherosclerosis, San Antonio, TX, April 1992, Elsevier Science Publishers.
  • MARCEL, Y.L., RASSART, E., BRISSETTE, L. and MILNE, R.W. (1992) Immunochemical studies of apolipoprotein structure and function in Structure and Function of Apolipoprotein, M. Rosseneu ed., CRC Press, Boca Raton, Florida, U.S.A., pp. 363-400.
  • MILNE, R.W., RASSART, E., and MARCEL, Y.L. (1993) Molecular Biology of Apo D. In: Current Opinion in Lipidology, vol. 4(2). Current Science, London, England, pp. 100-106. FRANK, P.G., and MARCEL, Y. L. (2000) Apolipoprotein A-I: Structure Function Analysis. J. Lipid Res. 41, 853-872.
  • MARCEL, Y.L., and KISS, R.S. (2003) Structure-Function relationships of apolipoprotein A-I: A flexible protein with dynamic lipid association. Current Opinion in Lipidology 14, 151-157.
  • MARCEL ,Y.L., OUIMET, M., and WANG, M.D. Cellular lipid traffic and lipid transporters: Regulation of efflux and HDL formation. In Cellular Lipid Metabolism, C. Ehnholm, Ed. Springer. Pg 73-106, 2009.

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