Sun, Louise

Overview 

Dr. Louise Sun is a cardiac anesthesiologist and data scientist at the University of Ottawa Heart Institute (UOHI), an associate professor of anesthesiology and epidemiology and clinical research chair in big data and cardiovascular outcomes at the University of Ottawa. Dr. Sun also holds an adjunct scientist position at the Institute for Clinical Evaluative Sciences (ICES).  She directs Big Data and Health Informatics Research at UOHI and heads the Cardiocore Big Data Research Unit and Team Soleil.

Background 

Dr. Sun received her medical degree from McMaster University in 2008. She completed her anesthesiology residency at the University of Ottawa in 2013 and received her Master of Science in epidemiology from Harvard University that same year. Dr. Sun completed a combined clinical and research fellowship in cardiac anesthesia at the University of Toronto in December 2014 and joined the UOHI in early 2015. She was appointed to the ICES faculty the following year. In September 2019, Dr. Sun was elected as a fellow of the American Heart Association (AHA).

Dr. Sun sits on the Society of Cardiovascular Anesthesiologists (SCA) Scientific Committee, and served on the Heart and Stroke Foundation (H&S) Canadian and European Scientific Review Committees. She is an advisory board member of the American Board of Artificial Intelligence in Medicine, an associate editor for the textbook Intelligence-Based Cardiology: Artificial Intelligence and Human Cognition in Cardiovascular Medicine and Cardiac Surgery, as well as a cardiology section editor for the Intelligence-Based Medicine journal.

In the broader medical community, Dr. Sun serves on the AHA Membership Committee, takes part on the leadership panel for the SCA Cerebral Protection Working Group as a methodologist, and is a scientific officer of the Canadian Cardiovascular Critical Care Society (CANCARE). She collaborates with CorHealth Ontario on the Task Force for Cardiac Surgery Reports Risk Adjustment, regional health authorities to evaluate and improve models of cardiac health care delivery, and health administrators to bring innovations to the bedside through digital applications and engineering of clinical devices.

Dr. Sun was a recipient of the uOttawa COVID-19 Recognition Award (2020) for innovative contribution to clinical operations through a series of precision-based digital applications to manage cardiac surgery waitlists and increasing ICU throughput. She was named National New Investigator by the Heart and Stroke Foundation of Canada (2020) and was awarded the Tier 2 Clinical Research Chair in Big Data and Cardiovascular Outcomes that same year. She was also a recipient of the uOttawa Junior Faculty Excellence Award (2019) for her outstanding contributions to research, education and professionalism in the Department of Anesthesia and Pain Medicine; and the UOHI Dr. Robert Roberts Award of Research Excellence (2019). She was amongst a panel of cardiovascular specialists selected to showcase the accomplishments of women in cardiovascular medicine and science at the Canadian Cardiovascular Congress in 2019. She was also a finalist for the American Heart Association’s Vivien Thomas Young Investigator Award (2018) and was named a top reviewer for Anesthesiology (2019) and the Annals of Internal Medicine (2015 and 2018).

Research & Clinical Interests 

Dr. Sun’s research is focused on leveraging big data, machine learning, innovative methods and technology to tackle key issues in healthcare delivery and outcomes for patients with heart failure and/or undergoing cardiovascular interventions. Her patient-centered research program aims to improve access to care and outcomes of women and men with cardiovascular disease, focusing on personalized risk stratification and long-term, patient-defined outcomes. Her program is funded by the Canadian Institutes of Health Research (CIHR), H&S Foundation, Ministry of Health and Long-Term Care, Canadian Frailty Network, the University of Ottawa, and the UOHI ORACLE Strategic Plan. Her work has garnered global interest.

Dr. Sun’s group has published significant findings, including work to define Patient-relevant Adverse Cardiovascular and noncardiovascular Events (PACE) (JAMA Netw Open 2021) and disability-free survival (Open Heart 2018, CMAJ Open 2021) as patient-centric outcomes in cardiovascular research; the comparative effectiveness of revascularization strategies (JAMA Cardiol 2020); and the impact of frailty (JAHA 2018, Ann Surg 2020), renal function (Ann Surg 2020), and patient sex (JAHA 2018, JAHA 2019) on long-term outcomes after cardiac surgery. Her study on the sex differences in outcomes of heart failure, published in the Canadian Medical Association Journal (2018) was featured in the New York Times. Her paper on the association between intraoperative hypotension and stroke was featured as “Article of the Month” (Anesthesiology 2018). Her work on identifying critical intraoperative blood pressure thresholds in association with acute kidney injury was ranked in the top three most cited articles in Anesthesiology (2017).

Clinical

  • Heart failure
  • Hypotension

Research

Dr. Sun’s research interests include:

  • Heart failure epidemiology, disability consequences and health service utilization.
  • Impact of cardiac surgery and percutaneous interventions on long-term outcomes including quality of life.

Methodology interests:

  • Precision medicine:
    • Personalized risk prediction modeling.
    • Sex and gender.
    • Biomarker discovery.
  • Population-based cohort studies and pragmatic clinical trials using large healthcare databases.
  • Informatics and data warehousing.
  • Software applications and hardware design.
Publications 

See at Google Scholar.

Selected publications:

  • Sun LY, Rodger J, Duffett L, Tulloch H, Crean AM, Chong AY, Rubens FD, MacPhee E, Mesana TG, Lee DS, van Diepen S, Beanlands RS, Ruel M, Julien AM, Bilodeau J. (2021). Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events through a Modified Delphi Process. JAMA Network Open. 4(1): e2032095.
  • Sun LY, Mielniczuk LM, Liu PP, Beanlands R, Chih S, Davies R, Coutinho T, Lee DS, Austin PC, Bader Eddeen A, Tu JV. (2020). Sex-Specific Temporal Trends in Ambulatory Heart Failure Incidence, Mortality and Hospitalization in Ontario, Canada from 1994-2013: a Population-Based Cohort Study. BMJ Open. 10(11):e044126.
  • Sun LY, Bader Eddeen A, Ruel M, MacPhee E, Mesana TG. (2020). Derivation and Validation of a Clinical Model to Predict Intensive Care Unit Length of Stay after Cardiac Surgery. JAHA. Sep 29:e017847.
  • Etherington E, Deng M, Boet S, Johnston A, Mansour F, Said H, Zheng K, Sun LY. (2020). The impact of physician sex/gender on processes of care, and clinical outcomes in cardiac operative care: A systematic review. BMJ Open. 10(9):e037139.
  • Sun LY, Gaudino M, Chen RJ, Bader Eddeen A, Ruel M. (2020). Long-Term Outcomes of Patients with Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting. JAMA Cardiology. Online first Apr 8:e200239.
  • Mamas MA, Brown SA, Sun LY. (2020). Coronary Artery Disease in Cancer patients; It’s always the small pieces that make the bigger picture. Mayo Clinic Proceedings. 95(9):1819-1821.
  • Ngu J, Jabagi H, Chung A, Boodhwani M, Ruel M, Bourke M, Sun LY. (2020). Defining an intraoperative hypotension threshold in association with de novo renal replacement therapy after cardiac surgery. Anesthesiology. 132(6):1447-1457.
  • Sun LY, Spence S, Benton S, Beanlands R, Bader Eddeen A, Lee DS. (2020). Age, Not Sex, Modifies the
  • Effect of Frailty on Long-term Outcomes after Cardiac Surgery. Annals of Surgery. Online first June 24. JIF: 9.5
  • Hayatsu Y, Ruel M, Bader Eddeen A, Sun LY. (2020). Single versus Multiple Arterial Revascularization in Patients with Reduced Renal Function: Long-Term Outcome Comparisons in 23,406 CABG Patients from Ontario, Canada. Annals of Surgery. Online first June 11.
  • Rubens FD, Coutinho T, Bader Eddeen A, Sun LY. (2020) The impact of a second arterial conduit on longterm post-discharge outcomes in women and men after coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery. S0022-5223(20)31007-2.

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