Wilkes, Peter

Overview 

Dr. Peter Wilkes is an Anesthesiologist and Clinical Associate in the Department of Anesthesia at the University of Ottawa Heart Institute. He is also Assistant Professor at the University of Ottawa.

Background 

Dr. Wilkes has an eclectic academic background. He received his MSc and PhD degrees in environmental/comparative physiology from the University of Calgary and then completed three years of post-doctoral training in the Department of Medical Physiology, also at the University of Calgary. There, he studied renal micropuncture techniques, atrial natriuretic peptide release and the measurement of lower esophageal sphincter pressure, receiving his MD in 1990. This was followed by a Residency in Anesthesia at the University of Western Ontario in London, Ontario, and an Intensive Care Fellowship at the University of Ottawa.

Dr. Wilkes joined the staff at the Heart Institute in 1994, where his clinical responsibilities include the Cardiac Operating Room and the Intensive Care Unit.

Research & Clinical Interests 

Dr. Wilkes has a long-standing research interest in electrolyte and acid-base physiology and is currently involved in an observational study looking at various measures of respiratory variability in Intensive Care Unit patients being weaned from mechanical ventilator support.

Publications 

LATEST PUBLICATIONS

  • " Wilkes PRH. Normal Strong Ion Difference, in: Stewart's Textbook of Clinical Acid Base Medicine, eds. John Kellum, Paul Elbers (in press).
  • " Wilkes PRH, Akbari A. Acid-Base in Pregnancy, in: Stewart's Textbook of Clinical Acid Base Medicine, eds. John Kellum, Paul Elbers (in press).
  • " Akabari, A, Wilkes PRH, Lindheimer M, Lepage N, Filler G. Reference ranges for electrolytes and anion gap and strong ion difference measured by ion specific electrodes in normal pregnancy. Hypertens Pregnancy 2007;26:111-119.
  • " Akbari A, Wilkes PRH, Lepage N, Filler G. Anion Gap and Strong Ion Difference in Normal Pregnancy. Canadian Society of Nephrology, Calgary, Alberta (2005).
  • " Wilkes PRH. Renal Function After Cardiac Surgery. Canadian Anesthesia Society, Calgary, Alberta (June 2006).

FULL LIST OF PAPERS IN REFEREED JOURNALS

  • " McMahon, B.R., Sinclair, F., Hassall, C.D., DeFur, P.L. and Wilkes, P.R.H. Ventilation and control of acid-base status during temperature acclimation in the crab, Cancer magister. J. Comp. Physiol. 128:109-116 (1978).
  • " Wilkes, P.R.H., DeFur, P.L. and McMahon, B.R. A new operational approach to PC02 determination in crustacean hemolymph. Respir. Physiol. 42:17-28 (1980).
  • " DeFur, P.L., Wilkes, P.R.H. and McMahon, B.R. Non-equilibrium acid-base status in C. productus: Role of exoskeletal carbonate buffers. Respir. Physio. 42:247-261 (1980).
  • " Wilkes, P.R.H., Walker, R.L., McDonald, D.G. and Wood, C.M. Respiratory, ventilatory, acid-base and ionoregulatory physiology of the White Sucker Catostomus commersoni: The influence of hyperoxia. J. Exp. Bio. 91:239-254 (1981).
  • " Wilkes, P.R.H. and McMahon, B.R. Effect of maintained hypoxic exposure on the crayfish Orconectes rusticus II. Modulation of haemocyanin oxygen affinity. J. Exp. Biol. 98:138-149 (1982).
  • " Wilkes, P.R.H. and McMahon, B.R. Effects of maintained hypoxic exposure on the crayfish Orconectes rusticus I. Ventilatory, acid-base and cardiovascular adjustments. J. Exp. Biol. 98:119-137 (1982).
  • " McDonald, D.G., Walker, R.L., Wilkes, P.R.H. and Wood, C.M. Proton excretion in the marine teleost Parophrus vetulus. J. Exp. Biol. 98:403-414 (1983).
  • " McDonald, D.G., Walker, R.L. and Wilkes, P.R.H. The interaction of environmental calcium and low pH on the physiology of the rainbow trout, Salmo gairdneri II. Branchial ionoregulatory mechanisms. J. Exp. Biol. 102:141-156 (1983).
  • " McMahon, B.R. and Wilkes, P.R.H. Emergence responses and serial ventilation in normoxic and hypoxic crayfish, Orconectes rusticus. Physio. Zool. 56:133-141 (1983).
  • " Hobe, H., Wilkes, P.R.H., Walker, R.L., Wood, C.M. and McMahon, B.R. Acid-base balance ionic status and renal function in resting and acid exposed white suckers (Catostomus commersoni). Can. J. Zool. 61:2660-2668 (1983).
  • " Booth, C.E., McMahon, B.R., DeFur, P.L. and Wilkes, P.R.H. Acid-base regulation during exercise and recovery in the blue crab. Callinectes sapidus. Respir. Physiol. 58:359-376 (1984).
  • " Wilkens, J.L., Wilkes, P.R.H. and Evans, J. Analysis of the scaphognathite ventilatory pump in the shore crab Carcinus maenas. II. Pumping efficiency and metabolic cost. J. Exp. Biol. 113:69-81 (1984).
  • " Wilkes, P.R.H. and McMahon, B.R. Responses of the stenohaline freshwater teleost (Catostomus commersoni) to hypersaline exposure. II. Transepithelial flux of sodium, chloride and 'acidic equivalents'. J. Exp. Biol. 121:95-114 (1986).
  • " Wilkes, P.R.H. and McMahon, B.R. Responses of the stenohaline freshwater teleost (Catostomus commersoni) to hypersaline exposure. I. The dependence of plasma pH and bicarbonate concentration on electrolyte regulation. J. Exp. Biol. 121:77-94 (1986).
  • " Wilkes, P.R.H., Mandin, H., Keane, P., Kirstein, J., Wong, T. and O'Conner, M. Circulating natriuretic peptide in rats with myocardial infarctions. Proceedings from the First World Congress on Biologically Active Peptides, (eds. B.M. Brenner and J.H. Laaragh), Raven Press, New York, pp. 477-480 (1987).
  • " Walker, R.L., Wilkes, P.R.H. and Wood, C.M. The effects of hypersaline exposure on oxygen affinity of the blood of the freshwater teleost, Catostomus commersoni. J. Exp. Biol. 142:125-142 (1989).
  • " Stone, J.A., Wilkes, P.R.H., Keane, P.M. Smith, E.R. and Tyberg, J.V. Pericardial pressure attenuates release of atriopeptin in volume expanded dogs. Am. J. Physiol. 256:H648-H654 (1989).
  • " Burgess, E., Duff, H. and Wilkes, P.R.H. Propafenone disposition in renal insufficiency and renal failure. J. Clin. Pharm. 29:112-113 (1989).
  • " Wilkes, P.R.H. and Lindsay, P. Bain Circuit occluded by a foreign body. Can. J. Anaesth. 41:137-138 (1994).
  • " Wilkes, P.R.H., Hoskin, R.W., MacCannell, K.L. and Tyberg, J.V. Re-examination of the balloon for use in gastro-intestinal manometry. Can. J. of Physiol. and Pharm. 72:979-984 (1994)
  • " Wilkes, P.R.H. Hypoproteinemia, strong ion difference and acid-base status in critically ill patients. J. Appl. Physiology. 84:1740-1748 (1998)
  • " Wilkes, P.R.H. Normal Strong Ion Difference, In: Stewart's Textbook of Clinical Acid Base Medicine, eds. John Kellum, Paul Elbers, (In Press)
  • " Wilkes, P.R.H., Akbari, A. Acid-Base in Pregnancy. In: Stewart's Textbook of Clinical Acid Base Medicine, eds. John Kellum, Paul Elbers (In Press)
  • " Akabari, A., Wilkes, P.R.H., Lindheimer, M., Lepage, N., Filler, G. Reference Ranges for Electrolytes and Anion Gap and Strong Ion Difference measured by Ion Specific Electrodes in Normal Pregnancy Hypertens Pregnancy. 26:111-119 (2007)
  • " Akbari, A., Wilkes, P.R.H., Lepage, N., Filler, G. Anion gap and strong ion difference in normal pregnancy Canadian Society of Nephrology, Calgary, Alberta (2005)
  • " Wilkes, P.R.H. Renal Function after Cardiac Surgery, Canadian Anesthesia Society, Calgary, Alberta (June 2006)

ABSTRACTS

  • " Wilkes, P.R.H., McMahon, B.R. Ventilatory and oxygen uptake responses of crayfish to long-term hypoxic exposure. Can. Soc. Zool. Meeting, Quebec City, Canada (1979).
  • " Wilkes, P.R.H. and McMahon, B.R. Responses to acute, severe hypoxic exposure on the crayfish, Orconectes rusticus Can. Physiol. Soc./Am. Physiol. Soc. Toronto, Canada (1980).
  • " Wilkes, P.R.H., DeFur, P.L. and McMahon, B.R. A new mathematical description of the crustacean acid-base status. Can. Soc. Zool. Meeting, Banff, Canada (1981).
  • " Wilkes, P.R.H. and McMahon, B.R. The role of the plasma ionic environment in determining acid-base status. Alberta Heritage Foundation for Medical Research, Edmonton, Canada (1982).
  • " Wilkes, P.R.H., and McMahon, B.R. Respiratory, acid-base and cardiovascular responses of the crayfish Orconectes rusticus to long term and chronic hypoxic exposure. Int. Sym. on Gas Exchange, Gas Transport and Acid-base Regulation in Lower Vertebrates. Max Planck Institute, Gottingen, Fed. Resp. Germany (1982).
  • " Wilkes, P.R.H. and McMahon, B.R., Effects of saline exposure on blood acid-base and electrolyte status in white sucker. Can. Soc. Zool. Ottawa, Canada (1983).
  • " Burgess, E., Schnurr, L. and Wilkes, P.R.H. Inaccurate serum sodium concentration by ion selective electrode analyzers. Letter to the Editor, Ann. Int. Med. 103:806 (1985).
  • " Wilkes, P.R.H., Burgess, E. and Schnurr, L. Erroneous measurements of sodium and chloride concentrations in hypoproteinemic patients. Soc. Critical Care Med. Washington, D.C (1986) Crit. Care Med. 14:406A (1985).
  • " Wilkes, P.R.H., Stone, J.A., Keane, P., Smith, E.R. and Tyberg, J.V. Role of the pericardium on release of atriopeptin by volume expansion in dogs. Canadian Cardiovascular Society, Edmonton, Alberta (1987).
  • " Wilkes, P.R.H., Hoskin, R.W., MacCannell, K.L. and Tyberg, J.V. Re-examination of the balloon for use in gastro-intestinal manometry. Canadian Federation of Biological Societies, Calgary, Alberta (1989).
  • " Gelb, A.W., Wilkes, P.R.H., Henderson, S.M., Zhang, C. Cerebral blood flow and metabolism during prolonged propofol anaesthesia Canadian Anaesthesia Society, Halifax, Nova Scotia. Canadian Journal of Anaesthesia 40:A68 (1993).
  • " Wilkes, P.R.H., Gupta, S., Legault, S. Biological variability of P0.1 airway occlusion pressure in mechanically ventilated patients Canadian Anesthesia Society, Ottawa, Ontario. (2003)

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