Essais cliniques

Sans recherche, pas de nouveaux traitements! Or, l’Institut de cardiologie de l’Université d’Ottawa (ICUO) est à cet égard un terrain d’autant plus fertile que sa recherche, si elle s’amorce et s’achève comme toute autre dans un laboratoire, a la particularité de se poursuivre et de se compléter au chevet des patients.

Jusqu’à 200 essais cliniques se déroulent à tout moment à l’ICUO à différentes étapes des études en cours. Nous sommes parfois à l’origine de ces études et les seuls à les mener. Nous collaborons aussi avec d’autres établissements à de vastes recherches d’envergure nationale ou internationale, qu’il nous arrive de diriger. Chaque année, des milliers de volontaires, pour la plupart des patients, mais aussi des personnes en bonne santé, participent à nos études. À l’heure actuelle, 50 scientifiques et chercheurs cliniques mènent des essais cliniques dans nos locaux.

Songez donc à vous porter volontaire pour participer à l’une de nos études. Pour plus d’informations, s’il vous plaît discuter avec un membre de votre équipe de soins, JoinAStudy@Ottawaheart.ca

Essais cliniques à l’Institut de cardiologie de l’Université d’Ottawa (en anglais seulement)

Statut Study
Recruiting Decision Support for Adults Facing Implantable Cardioverter-Defibrillator Pulse Generator Replacement
  • Conditions: Death, Sudden, Cardiac,   Death, Sudden,   Cardiovascular Diseases
  • Interventions: Behavioral Decision Support
Recruiting Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis
  • Sponsor: Boca Raton Regional Hospital,   AstraZeneca,   Ottawa Heart Institute Research Corporation
Recruiting A Study to Evaluate Efficacy and Safety of QPI-1002 for Prevention of Acute Kidney Injury Following Cardiac Surgery
Recruiting Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Heart and Stroke Foundation of Canada
Recruiting Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
  • Conditions: Diabetes Mellitus,   Coronary Artery Disease
  • Interventions: Device Pressure Wire Certus, St. Jude Medical, USA
Recruiting Mobilization of Endothelial Progenitor Cells and Aspirin
  • Interventions: Drug Aspirin
Recruiting 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
  • Interventions: Radiation 99mTc-rhAnnexin V-128
Recruiting Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training
Recruiting Exercise Training in Patients With Atrial Fibrillation (OPPORTUNITY Study)
Recruiting Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Population Health Research Institute,   Bristol-Myers Squibb,   Pfizer,   Medtronic
Recruiting The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
  • Sponsor: St. Michael's Hospital, Toronto,   Ottawa Heart Institute Research Corporation,   London Health Sciences Centre
Recruiting Randomized On-X Anticoagulation Trial
Recruiting Biomarkers to Classify Heart Failure
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Genome Canada,   Roche Diagnostics International
Recruiting The Ottawa AF Cardioversion Protocol
  • Interventions: Device Lifepak 20E Defibrillator, Licence No 61944
Recruiting Canadian SCAD Study
  • Interventions: 
  • Sponsor: Cardiology Research UBC,   Canadian Institutes of Health Research (CIHR)
Recruiting Impact of Preoperative FFR on Arterial Bypass Graft Functionality
  • Interventions: Procedure Fractional Flow Reserve (FFR)
Recruiting Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
  • Interventions: Other Therapeutic Hypothermia
Recruiting Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis
  • Conditions: Hypertrophic Cardiomyopathy,   Acute Coronary Syndrome
  • Interventions: Radiation 99mTc-NC100692
Recruiting HYbrid CoronAry Revascularization in DiabeticS
  • Conditions: Diabetes,   Heart Disease
Recruiting Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation
  • Conditions: Heart Disease,   Congestive Heart Failure,   Atrial Fibrillation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)
  • Conditions: Heart Failure,   Coronary Artery Disease,   Ischemic Cardiomyopathy,   Non-ischemic Cardiomyopathy
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   The Finnish Funding Agency for Technology and Innovation (TEKES)
Recruiting Use of Glidesheath Slender to Reduce Radial Artery Occlusion and Vascular Access Site Complications Following Transradial Coronary Angiography
  • Conditions: Embolism and Thrombosis of the Radial Artery,   Coronary Heart Disease
Recruiting Evaluation of the Ottawa Model for Smoking Cessation in Diabetes Education Programs
  • Conditions: Pre-diabetic,   Diabetic Type II Mellitus
  • Interventions: Behavioral Ottawa Model for Smoking Cessation
Recruiting Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
  • Conditions: Sleep Apnea,   Heart Failure
  • Interventions: Device Adaptive Servo Ventilation
  • Sponsor: Toronto Rehabilitation Institute,   Canadian Institutes of Health Research (CIHR),   Philips Respironics
Recruiting Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
  • Interventions: Other single photon emission computed tomography
  • Sponsor: Ottawa Heart Institute Research Corporation,   GE Healthcare
Recruiting AnaConDa Long Term Sedation Study
Recruiting The Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial
  • Sponsor: Ottawa Hospital Research Institute,   Canadian Institutes of Health Research (CIHR)
Recruiting The Effects of Statin Therapy on Coronary Flow Reserve and Inflammatory Markers in HIV-Positive Patients
  • Conditions: Human Immunodeficiency Virus (HIV),   Cardiovascular Disease (CVD)
  • Interventions: Drug Rosuvastatin
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario HIV Treatment Network
Recruiting Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
  • Sponsor: Laval University,   University Hospital, Brest
Recruiting Cardiac FDG PET Viability Registry
  • Conditions: Heart Failure,   Ischemic Heart Disease,   Myocardial Dysfunction
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care
Recruiting Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
  • Interventions: Procedure Catheter ablation
Recruiting Tailored Antiplatelet Therapy Following PCI
  • Conditions: Coronary Artery Disease,   Acute Coronary Syndrome,   Stenosis
  • Sponsor: Mayo Clinic,   Spartan Bioscience Inc.,   Applied Health Research Centre,   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
  • Conditions: Myocardial Infarction,   Sudden Death
  • Sponsor: University of Calgary,   Canadian Institutes of Health Research (CIHR),   Alberta Innovation and Science,   Medtronic,   GE Healthcare
Recruiting Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   Bayer,   Biotronik SE & Co. KG
Recruiting Strategy of Continued Versus Interrupted Novel Oral Anti-coagulant at Time of Device Surgery in Patients With Moderate to High Risk of Arterial Thromboembolic Events
  • Sponsor: Ottawa Heart Institute Research Corporation,   Boehringer Ingelheim,   Heart and Stroke Foundation of Canada
Recruiting Stem Cell Mobilization by G-CSF Post Myocardial Infarction to Promote Myocyte Repair
  • Interventions: Drug Granulocyte Colony Stimulating Factor
  • Sponsor: University of Ottawa,   Canadian Institutes of Health Research (CIHR)
Recruiting Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence
Recruiting The Efficacy and Economics of Exercise Maintenance Post-Cardiac Rehabilitation
  • Interventions: Behavioral Exercise Facilitator Intervention
  • Sponsor: Ottawa Heart Institute Research Corporation,   Heart and Stroke Foundation of Ontario
Recruiting Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers
Recruiting Cardiovascular Inflammation Reduction Trial
  • Sponsor: Brigham and Women's Hospital,   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting Rubidium Elution System Performance Testing
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Jubilant DraxImage Inc.
Recruiting Cardiac Sarcoidosis Multi-Center Prospective Cohort
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Canadian Institutes of Health Research (CIHR)
Recruiting ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
  • Conditions: Heart Failure,   Obstructive Sleep Apnea,   Central Sleep Apnea
  • Interventions: Other [C11]Acetate and HED PET
Recruiting International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
  • Conditions: Cardiovascular Diseases,   Coronary Disease,   Coronary Artery Disease,   Heart Diseases,   Myocardial Ischemia
  • Sponsor: New York University School of Medicine,   New York University,   Stanford University,   National Heart, Lung, and Blood Institute (NHLBI),   Albany Stratton VA Medical Center,   Cedars-Sinai Medical Center,   Columbia University,   Duke University,   East Carolina University,   Emory University,   Harvard University,   Massachusetts General Hospital,   Montreal Heart Institute,   University of British Columbia,   University of Missouri, Kansas City,   Vanderbilt University
Recruiting PERIGON Pivotal Trial
  • Interventions: Device Model 400 aortic valve bioprosthesis
  • Sponsor: Medtronic Cardiovascular,   Medtronic
Recruiting Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV
  • Sponsor: Dr. Bob Sheldon,   Vanderbilt University
Recruiting Randomized Trial of Nordic Walking vs. Standard Cardiac Rehabilitation in Patients With Heart Failure
  • Interventions: Behavioral Nordic Walking
Recruiting Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
  • Conditions: Heart Failure,   Atrial Fibrillation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk
  • Conditions: Acute Coronary Syndrome,   Percutaneous Coronary Intervention
  • Interventions: Drug Ticagrelor, Prasugrel, Clopidogrel
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Femoral Versus Radial Access for Primary PCI
  • Conditions: Myocardial Infarction,   STEMI
  • Interventions: Procedure Primary Percutaneous Coronary Intervention (PPCI)
Recruiting Transfusion Requirements in Cardiac Surgery III
Recruiting IMAGE-HF Project I-C: Computed Tomographic Coronary Angiography for Heart Failure Patients
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   The Finnish Funding Agency for Technology and Innovation (TEKES)
Recruiting SodiUm SeleniTe Adminstration IN Cardiac Surgery (SUSTAIN CSX®-Trial).
  • Sponsor: Daren K. Heyland,   biosyn Arzneimittel GmbH,   Queen's University,   RWTH Aachen University
Recruiting Routine vs Selective Cardiac Magnetic Resonance in Non-Ischemic Heart Failure
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   The Finnish Funding Agency for Technology and Innovation (TEKES)

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