Essais cliniques

Sans recherche, pas de nouveaux traitements! Or, l’Institut de cardiologie de l’Université d’Ottawa (ICUO) est à cet égard un terrain d’autant plus fertile que sa recherche, si elle s’amorce et s’achève comme toute autre dans un laboratoire, a la particularité de se poursuivre et de se compléter au chevet des patients.

Jusqu’à 200 essais cliniques se déroulent à tout moment à l’ICUO à différentes étapes des études en cours. Nous sommes parfois à l’origine de ces études et les seuls à les mener. Nous collaborons aussi avec d’autres établissements à de vastes recherches d’envergure nationale ou internationale, qu’il nous arrive de diriger. Chaque année, des milliers de volontaires, pour la plupart des patients, mais aussi des personnes en bonne santé, participent à nos études. À l’heure actuelle, 50 scientifiques et chercheurs cliniques mènent des essais cliniques dans nos locaux.

Pour plus d’informations, contactez JoinAStudy@ottawaheart.ca

Essais cliniques à l’Institut de cardiologie de l’Université d’Ottawa (en anglais seulement)

Statut Study
Recruiting Randomization of Single vs Multiple Arterial Grafts
  • Conditions: Coronary Artery Disease,   Heart Diseases
  • Sponsor: Weill Medical College of Cornell University,   National Heart, Lung, and Blood Institute (NHLBI),   Canadian Institutes of Health Research (CIHR)
Recruiting PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban
  • Conditions: Aortic Valve Disease,   Aortic Valve Stenosis,   Aortic Valve Failure
  • Sponsor: CryoLife, Inc.,   Duke Clinical Research Institute
Recruiting The Psychological, Social, and Economic Impacts of COVID-19
  • Conditions: COVID-19,   Chronic Disease,   Psychiatric Disorder,   Cardiovascular Diseases
  • Interventions: 
  • Sponsor: University of Ottawa,   Hopital du Sacre-Coeur de Montreal,   Sunnybrook Health Sciences Centre,   Southlake Regional Health Centre,   The Ottawa Hospital Research Institute,   Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal,   Centre for Addiction and Mental Health,   CHEO Research Institute,   Ottawa Heart Institute Research Corporation,   McGill University,   Johns Hopkins University,   Université de Montréal,   The Royal's Institute of Mental Health Research
Recruiting Exploratory Study of the Edwards Transcatheter Atrial Shunt System (ALt FLOW CANADA)
  • Interventions: Device Atrial Shunt
Recruiting Multi-Center Evaluation of Feasibility of SPECT Measurement of Myocardial Blood Flow and Reserve
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   GE Healthcare
Recruiting QPI-1002 Phase 3 for Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery
Recruiting HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
  • Conditions: Heart Transplant Failure and Rejection,   Heart Failure,   Heart Diseases,   Heart Failure,Congestive,   Transplant, Failure, Heart,   Transplant Failure
  • Interventions: 
  • Sponsor: University of British Columbia,   Canadian Institutes of Health Research (CIHR),   PROOF Centre of Excellence,   Duke University,   University of Nebraska,   Toronto General Hospital,   St. Paul's Hospital, Canada
Recruiting On-X Aortic Prosthetic Heart Valve Low Dose Warfarin Post Approval Clinical Registry Study
  • Interventions: Device On-X Aortic Heart Valve replacement
Recruiting Olaparib for PAH: a Multicenter Clinical Trial
  • Interventions: Drug Olaparib
  • Sponsor: Laval University,   Canadian Institutes of Health Research (CIHR),   AstraZeneca
Recruiting ECG Belt for CRT Response
  • Interventions: Device ECG Belt Research System
Recruiting Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
  • Conditions: Ascending Aortic Aneurysm Enlargement,   Ascending Aorta Aneurysm
  • Interventions: Procedure Thoracic Aortic Surgery
  • Sponsor: Ottawa Heart Institute Research Corporation,   University of Calgary
Recruiting An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)
  • Sponsor: GE Healthcare,   Pharmaceutical Product Development, LLC
Recruiting Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation
  • Interventions: Drug Sildenafil Citrate
  • Sponsor: University of Calgary,   Pfizer
Recruiting Antiarrhythmics or Ablation for Ventricular Tachycardia 2
  • Sponsor: John Sapp,   Heart and Stroke Foundation of Canada,   Abbott Medical Devices,   Biosense Webster, Inc.,   Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   Cardiac Arrhythmia Network of Canada,   Abbott,   Nova Scotia Health Authority
Recruiting TRILUMINATE Pivotal Trial
  • Interventions: Device Tricuspid valve repair
Recruiting Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation
Recruiting Effect of a Hybrid Rehabilitation Program on Walking, Quality of Life & Cardiovascular Risk in People With PAD
  • Interventions: Behavioral HY-PAD
  • Sponsor: Ottawa Heart Institute Research Corporation,   AFP Innovation Fund
Recruiting Post-Surgical Enhanced Monitoring for Cardiac Arrhythmias and Atrial Fibrillation
  • Conditions: Cardiac Arrhythmias,   Atrial Fibrillation
  • Interventions: Device a wearable adhesive cardiac monitoring device
  • Sponsor: St. Michael's Hospital, Toronto,   Southlake Regional Health Centre,   University Health Network, Toronto
Recruiting E-health Intervention for Cardiac Rehabilitation
  • Conditions: Coronary Heart Disease,   Valve Disease, Heart
Recruiting Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
Recruiting Smartphone Assessment Prior Radial Artery Harvesting for CABG
Recruiting Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
  • Conditions: Atrial Fibrillation,   Stroke,   Bleeding
  • Sponsor: Icahn School of Medicine at Mount Sinai,   National Heart, Lung, and Blood Institute (NHLBI),   Vanderbilt University Medical Center
Recruiting Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation (Exercise-AF)
  • Conditions:Persistent or Permanent Atrial Fibrillation (Exercise-AF)
  • Interventions:Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks. Participants will attend on-site high-intensity interval training two times weekly for 12 weeks.
Recruiting AMPLATZER™ LAA Occluder Post Approval Study (PAS)
  • Conditions: Atrial Fibrillation,   Thromboembolism,   Stroke
  • Interventions: Device AMPLATZER™ LAA Occluder
Recruiting Cardiac Sarcoidosis Randomized Trial
  • Conditions: Cardiac Sarcoidosis,   Sarcoidosis
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Early Post Transplant Cardiac Allograft Vasculopathy
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Toronto General Hospital
Recruiting The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
  • Sponsor: Ottawa Heart Institute Research Corporation,   London Health Sciences Centre,   Heart Center Leipzig - University Hospital,   Fortis Escorts Heart Institute,   The Methodist Hospital System,   Carolinas Medical Center,   Gundersen Lutheran Health System,   Jilin Heart Hospital,   Far Eastern Memorial Hospital,   Medtronic,   Apollo Hospitals,   Ichinomiya-Nishi Hospital,   Fresno Heart and Surgical Hospital
Recruiting Peer Support for Women With Heart Disease: Women@Heart
  • Conditions: Coronary Heart Disease,   Women's Health
  • Interventions: Behavioral Women@Heart Program
Recruiting Thoraflex Hybrid Post-Market Study
  • Conditions: Acute Aortic Dissection,   Aortic Rupture,   Penetrating Aortic Ulcer,   Aortic Dissection,   Aortic Aneurysm, Thoracic
  • Interventions: Behavioral EQ-5D-5L QOL questionnaire
Recruiting Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation
  • Interventions: Procedure Catheter ablation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Heart and Stroke Foundation of Canada
Recruiting Biomarker Guided Discharge of Heart Failure Patients
  • Interventions: Other Biomarker guided discharge algorithm
  • Sponsor: Peter Liu,   Genome Canada,   Roche Diagnostics,   Ottawa Heart Institute Research Corporation
Recruiting Avoid Transvenous Leads in Appropriate Subjects
  • Interventions: Device Implantable Cardioverter Defibrillator
  • Sponsor: Population Health Research Institute,   Boston Scientific Corporation
Recruiting Sub-Clinical Atrial Fibrillation Biomarker Study
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Population Health Research Institute,   Genome Canada,   Bristol-Myers Squibb,   Pfizer,   Medtronic,   Canadian Institutes of Health Research (CIHR)
Recruiting Detection of Atrial Fibrillation After Cardiac Surgery
  • Conditions: Atrial Fibrillation,   Atrial Flutter,   C.Surgical Procedure, Cardiac,   Arrhythmias, Cardiac
Recruiting Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs
  • Sponsor: Northern Therapeutics,   Ottawa Hospital Research Institute
Recruiting Personalized Dosing of Nicotine Replacement (NRT to Effect)
  • Conditions: Tobacco Use Disorder,   Nicotine Dependence
  • Sponsor: Centre for Addiction and Mental Health,   Canadian Cancer Society Research Institute (CCSRI),   Ottawa Heart Institute Research Corporation
Recruiting Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis
  • Sponsor: Boca Raton Regional Hospital,   AstraZeneca,   Ottawa Heart Institute Research Corporation
Recruiting Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial
  • Sponsor: Lawson Health Research Institute,   Medtronic
Recruiting Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
  • Conditions: Diabetes Mellitus,   Coronary Artery Disease
  • Interventions: Device Pressure Wire Certus, St. Jude Medical, USA
Recruiting Mobilization of Endothelial Progenitor Cells and Aspirin
  • Interventions: Drug Aspirin
Recruiting Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Population Health Research Institute,   Bristol-Myers Squibb,   Pfizer,   Medtronic,   Canadian Institutes of Health Research (CIHR),   Hamilton Health Sciences Foundation
Recruiting The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
  • Sponsor: St. Michael's Hospital, Toronto,   Ottawa Heart Institute Research Corporation,   London Health Sciences Centre
Recruiting SodiUm SeleniTe Administration IN Cardiac Surgery (SUSTAIN CSX®-Trial).
  • Sponsor: Daren K. Heyland,   biosyn Arzneimittel GmbH,   Queen's University,   RWTH Aachen University
Recruiting Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
  • Interventions: Other Therapeutic Hypothermia
Recruiting Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation
  • Conditions: Heart Disease,   Congestive Heart Failure,   Atrial Fibrillation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
  • Sponsor: Laval University,   University Hospital, Brest
Recruiting Use of Glidesheath Slender to Reduce Radial Artery Occlusion and Vascular Access Site Complications Following Transradial Coronary Angiography
  • Conditions: Embolism and Thrombosis of the Radial Artery,   Coronary Heart Disease
Recruiting Cardiac Sarcoidosis Multi-Center Prospective Cohort
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Canadian Institutes of Health Research (CIHR)
Recruiting Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
  • Interventions: Other single photon emission computed tomography
  • Sponsor: Ottawa Heart Institute Research Corporation,   GE Healthcare
Recruiting Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
  • Conditions: Sleep Apnea,   Heart Failure
  • Interventions: Device Adaptive Servo Ventilation
  • Sponsor: Toronto Rehabilitation Institute,   Canadian Institutes of Health Research (CIHR),   Philips Respironics
Recruiting Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
  • Interventions: Procedure Catheter ablation
Recruiting Cardiac FDG PET Viability Registry
  • Conditions: Heart Failure,   Ischemic Heart Disease,   Myocardial Dysfunction
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care
Recruiting Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   Bayer,   Biotronik Canada Inc
Recruiting Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
  • Conditions: Myocardial Infarction,   Sudden Death
  • Sponsor: University of Calgary,   Canadian Institutes of Health Research (CIHR),   Alberta Innovation and Science,   Medtronic,   GE Healthcare
Recruiting Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence
Recruiting ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
  • Conditions: Heart Failure,   Obstructive Sleep Apnea,   Central Sleep Apnea
  • Interventions: Other [C11]Acetate and HED PET
Recruiting PERIGON Pivotal Trial
  • Interventions: Device Model 400 aortic valve bioprosthesis
  • Sponsor: Medtronic Cardiovascular,   Medtronic

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