Cardiovascular Research Methods Centre

The Cardiovascular Research Methods Centre collaborates with Heart Institute investigators during all stages of the research process, from protocol design to drafting of a final manuscript for submission to a peer-reviewed journal:

The Centre aims to:

  1. To collaborate with clinician and basic scientists at all stages of design, development, execution and analysis of experimental protocols. 
  2. To develop unique research methodologies for example in the fields of genetic wide association studies and Randomized Clinical Trials.
  3. To co-ordinate regular monthly meetings between methodologists and clinical and basic scientists (the goal of these meetings would be to brainstorm ideas, discuss experimental design, review grant applications etc.).
  4. To develop educational programs in cardiovascular research methodology and statistics (regular courses and workshops at various levels will be offered for clinical and basic scientists as well as other members of staff; these might be mandatory for cardiology residents, first year cardiology fellows and first year basic scientists). 
  5. To develop and maintain research database infrastructure.
  6. To increase success with grant applications (as part of this aim all grant applications will be reviewed by the centre; further all applications will be provided with a letter of support from the Centre Director which will include a breakdown of budget for methodological support).

The Methods Centre provides these collaborative services to ensure that the latest experimental-design technologies and methods are available to Heart Institute researchers, that the data obtained in research studies are maintained at the highest level of quality and integrity, that the most appropriate and latest statistical analysis techniques are used, and that good clinical practices are allowed.

Teaching Activities

The Centre’s staff provides statistical and epidemiological research training for residents, clinical fellows and fundamental scientists at the Heart Institute.  Teaching modules include experimental de3signs, basic and advanced statistical methods, the design and analysis of randomized and non-randomized clinical trials, procedures for systematic reviews and meta-analysis, health technology assessment, economic evaluations and developing and evaluating decision support technologies.

The Centre’s staff can also coordinate training for research personnel in standard operating procedures (SOPs) designed to ensure good clinical practices and good laboratory practices in research study methods and data integrity and analysis.

Projects 

2005-2010    ACE-Inhibition for the Preservation of Renal Function and Patient Survival in Kidney Transplantation
    Principal Investigator:  G. Knoll
    Co-investigators:  D. Fergusson, S. Gourishankar, B. Kiberd, D. Treleaven, M. Karpinski, N. Muirhead, M. Cantarovich, R. Prqasad, J. Gill, P. Hébert, K. McLaughlin, G. A. Wells
    Canadian Institutes of Health Research (CIHR) 
    Funding:  $2,946,260 (1st Year $496,763)

2005-2010     Endocrinology of Cardiac Failure and Inflammation
    Principal Investigator:  A. de Bold
    Co-Investigators :  M. Kuroski de Bold, H. Haddad, J. Veinot, G. A. Wells, P. Hendry, R. Masters
    Canadian Institutes of Health Research (CIHR)
    Total amount awarded $553,500 (1st Year $187,640)

2006-2010    Resistance Exercise in Already-active Diabetic Individuals (READI)
    Principal Investigator:  R. Sigal
    Co-Investigators:  G. Kenny, L. Donovan, M. Riddell, B. Perkins, S. Hadjiyannakis, G. Goldfield, R. Gougeon, D. Prud’homme, D. Coyle, G. A. Wells, A. Edwards, D. Pacaud, P. Sargious, G. Ford
    Canadian Institutes of Health Research (CIHR)  
    Funding:  $1,256,975 (1st Year $306,910)

2007-2010     Tool Development:  Improving the Utility of Administrative Databases for Post-Marketing Surveillance of Serious Adverse Events and Health Service Utilization in Patients Receiving Biologic Response Modifying Drugs for Rheumatoid Arthritis
         Principal Applicants:  C. Bombardier, S. Bernatsky, J. Hux
    Co-Applicants:  J. Boyle, J. Pope, A. Cividino C. Thorne, G. A. Wells, 
    G. Tomlinson, M. Paterson
    Canadian Institutes of Health Research (CIHR)
    Funding:  $281,517 (1st Year $41,248)

2007-2010    A Study to Develop Clinical Decision Rules for the Hospital Admission of Patients with Acute Dyspnea
    Principal Investigator:  I. Stiell
    Co-investigators: S. Aaron, B. Rowe, R. Brison, A. Forster, G. A. Wells, J. Perry, 
    L. Calder
    Canadian Institutes of Health Research (CIHR)
    Funding:  $350,853 (1st Year $158,371)

2007-2010      A program to reduce cardiovascular risk among family members of patients with 
    Coronary Artery Disease
    Principal Investigator:  B. Reid, L. Mosca
    Co-Investigators: A. Pipe, H. Mochari, G. A. Wells, P. O’Farrell, C. Blanchard, S. Papadakis, M. Slovinec, L. Beaton
    Heart and Stroke Foundation of Canada
    Funding: $301,029 (1st Year $100,343)

2007-2010    Effectiveness of Dispatch-Assisted CPR Instructions:  An Evaluation of 9-1-1 
    Calls
    Principal Investigator:  C. Vaillancourt
    Co-Investigators:  I. Stiell, G. A. Wells
    Canadian Institutes of Health Research (CIHR)
    Funding:  $378,516 (1st Year $185,500)

2007-2011    Phase I:  Clinical Decision Rule for High Risk TIA Patients in the ED
    Nominated Principal Applicant:  J. Perry
    Co-Applicants:  M. Sharma, M. Emond, I. Stiell, G. A. Wells, M. Sivilotti, A. Worster
    Canadian Institutes of Health Research (CIHR)
    Funding:  $537,844 (1st Year $162,001)
    
2007-2012    Genome-wide Scan to Identify Coronary Artery Disease Genes
    Principal Investigator:  R. Roberts
    Co-Investigators:  A. Stewart, R. McPherson, G. A. Wells
    Canadian Institutes of Health Research (CIHR)
    Funding $750,000 (1st Year $151,978)

2007-2012    Development of a Canadian Cardiovascular Genetics Centre – the first centre in Canada dedicated to Genetics of Cardiovascular Disease    
    Principal Investigator:  R. Roberts    
    Co-investigators:  M. Andrade, R. Beanlands, M. Gollob, Y. Marcel, R. McPherson, A. Stewart, A. Tang, F. Tesson, G. A. Wells
    Canadian Foundation of Innovation ($4,713,346) 
    Partner Contributions ($7,070,019)
    Funding:  $11,783,365 (1st Year $2,571,203) 

2008-2010    Evaluation of the Safety of C-Spine Clearance by Emergency Department Triage Nurses
     (Phase IV)
    Principal Applicant:  I. Stiell
    Co-Applicants:  J. Brehaut, B. Davies, J. Grimshaw, A. O’Connor, J. Perry 
    and G. A. Wells
    Canadian Institutes of Health Research (CIHR) – Operating
    Funding:  $157,354 (1st Year  $78,677)
    
2008-2010    Long-term Effects of Cardiac Resynchronization Therapy on LV Remodeling and Ventricular Arrhythmia:  The Reverse Remodeling Study
    Nominated Principal Applicant:  D. Birnie
    Co-Applicants:  T. Ruddy, J. Sapp,  G. A. Wells
    Heart and Stroke Foundation of Ontario
    Funding:  $98,337 (1st Year $20,100)    

2008-2010    A Survey of Factors Associated with the Successful Recognition of Agonal 
    Breathing and Cardiac Arrest by 9-1-1 Call Takers (Pilot Project Grant)
    Principal Applicant:  C. Vaillancourt
    Co-Applicants:  J. Grimshaw, J. Brehaut, I. Stiell, G. A. Wells, M. Osmond
    Heart and Stroke Foundation of Ontario (HSFO)
    Funding:  $49,000  (1st Year $24,921)

2008-2010    Angiotensin Receptor Blocker Post Ablation to Prevent Recurrent Atrial Fibrillation
    Principal Applicant:  G. A. Wells (Mentor)
    Co-investigator:  R. Parkash (Mentee)
    Canadian Institutes of Health Research (CIHR)
    Funding:  $20,000 (1st Year $6,666)

2008-2010     Anisnabe Kekendazone: building from the Ottawa ACADRE
    Nominated Principal Applicant:  N. Andersson, A. Macaulay, G. Sioui
    Co-Applicants:  J. Arnason, K. Barlow, M. Brklacich, M. Cargo, D. Dannenbaum, M. Dion-Stout, N. Edwards, G. Egeland, S. Findlay, B. Flynn, K. Glass, N. Gibson, K. Gray-Donald, M. Green, P. Haddad, E. Harper, L. Levesque, J. Little, A. O’Connor, O. Receveur, M. Rosenberg, B. Shea, J. Torrie, N. Trocme, P. Tugwell, S. Vollant, G. A. Wells, K. Yeates
    Canadian Institutes of Health Research (CIHR)
    Funding:  $1,493,333 (1st Year $600,000) 

2008-2011    Effectiveness and Optimal Use of Biologic Response Modifying Drugs for the Treatment of Rheumatoid Arthritis in Ontario
    Principal Investigator:  Claire Bombardier, Janet Hux
    Co-Applicants:  C. Thorne, G. Tomlinson, C. Hofstetter, S. Bernatsky, J. Boyle, V. Bykerk, A. Cividino, A. Lyddiatt, M. Paterson, J. Pope and G. A. Wells
    Ministry of Health and Long Term Care
    Funding: $700,000 (1st Year $300,000)

2008-2013    CIHR Emerging Team in Genomics in Screening
    Nominated Principal Applicant:  B. Wilson, 
    Principal Applicants:  Julian Little, June Carroll, Beth Potter, David Castle
    Co-Applicants:  Judith Allanson, Fiona Miller, Mario Cappelli, Pranesh Chakraborty, 
    Joe T.R. Clarke, George Wells, Denise Avard, Holly Etchegary, Tim Caulfield, Louise Lemyre & Karine Morin
    Canadian Institutes of Health Research (CIHR) 
    Funding:  $1,597,865 (1st Year $300,000)

193 2009-2010    Obstructive Sleep Apnea as a Risk Factor for Clopidogrel Unresponsiveness in Patients 
    Undergoing Percutaneous Coronary Intervention:  Prevalence, Mechanisms and Possible 
    Influence on Clinical Outcomes
    Principal Applicant:  D. So
    Co-Applicants:  G. Chandy, C. Glover, M. Labinaz, M. Le May, J. Leech, 
    G. A. Wells
    Heart and Stroke Foundation of Canada 
    Funding:  $146,200 (1st Year 79,100)

2009-2011    Improving Continuity of Care for Individuals with Chronic Disease
    Principal Applicant:  A. Cranney
    Co-Applicants:  G. Alexander, B. De Bruijn, A. Forster, J. Grimshaw, E. Keely, 
    C. Kendall, J. Martin, I. Stiell, G. A. Wells, J. Worthington
    Canadian Institutes of Health Research (CIHR)
    Funding :  $195,526 (1st Year $97,763)

2009-2010    Using Technology to Create a New Chronic Disease Management Model for Francophone Patients – An Integration Project
    Principal Investigator:  H. Sherrard
    Co-Investigators: L. Duchesne, C. Struthers, G. A. Wells
    Socété Santé en Français 
    Funding:  $190,290

2009-2011    Field Validation of an Early Inflammatory Arthritis Screening Tool in the Canadian Primary Health Care Environment
    Principal Investigator:  M. Bell
    Co-Investigators:  V. Bykerk, G. A. Wells, P. Tugwell, D. Manca, M. Godwin
    Canadian Arthritis Network
    Funding:  $240,000 (1st Year $120,000)

2009-2011    Remote ECG Monitoring
    Printipal Investigator:  H. Yang
    Co-Investigators:  T. Ruddy, J. Watters, W. Gofton, P. Jetty, G. A. Wells, A. Chaput
    The Ottawa Hospital Academic Medical Organization Innovation Fund
    Funding:  $606,502 (1st Year $453,372)

2009-2012    BRUISE CONTROL : Bridge oR continUe coumadIn for device SurgEry randomized CONTROLled Trial
    Principal Applicants:  D. Birnie, V. Essebag
    Co-Applicants:  A. Krahn, C. Simpson, J. Healey, A. Tang, S. Sivakumaran, 
    G. A. Wells
    Canadian Institutes of Health Research (CIHR) – Randomized Controlled Trial
    Funding:  $952,839 (1st Year $145,311)
    
2009-2014    Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia 
    Principal Applicants:  ShiWu Wen, W. Fraser
    Nominated Co-Principal Applicant:  M. Walker
    Co-Applicants: G. Smith, D. Fergusson, G. A. Wells, D. Coyle, A. Ohlsson, S. Davidge
    Canadian Institutes of Health Research (CIHR) – Randomized Controlled Trial
    Funding:  $6,448,423 (1st Year $1,375,734)

2009-2014    Imaging Modalities to Assist with Guiding Therapy and the Evaluation of Patients with Heart Failure (IMAGE-HF)
    Principal Applicants:  R. Beanlands, J. Knuuti, G. A. Wells, M. Friedrich, G. Wright, J-C. Tardif, S. Yla-Herttuala, M. Arnold, 
    Co-Applicants:  E. Larose, D. Paterson, R. de Kemp, D. Birnie, J. White, G. Wisenberg, B. Chow, D. Coyle, F. Prato, J. Ezekowitz, T-Y. Lee, E. O’Meara
    Canadian Institutes of Health Research - Team Grant
    Funding:  $2,500,000 (1st Year $375,000)

202 2010    Comparison of Chronic Disease Care Delivery Amongst Primary Care Models in Ontario
    Principal Applicant:  C. Liddy
    Co-Applicants:  W. Hogg, S. Dahrouge, G. A. Wells
    Ministry of Health and Long Term Care, Primary Health Care System (PHCS) Program
    Funding:  $15,000

203 2010    Planning Meeting for a RCT Grant for the Treatment of AF in Heart Failure Patients
    Principal Applicant:  A. Tang
    Co-Applicants:  R. Parkash, M. Talajic, A. Verma, G. A. Wells
    Canadian Institutes of Health Research (CIHR) – Planning Grants
    Funding:  $19,488

2010-2011    Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging
    (RB-ARMI)
    Principal Applicants:  R. de Kemp, R. Beanlands, G. A. Wells,
    Co-Applicants: K. Gulenchyn, J-C. Tardif, G. Wisenberg, P. Pibarot, D. Coyle, E. Turcotte, F. Harel
    Canadian Institutes of Health Research (CIHR) - Operating
    Funding: $1,121,700 (1st Year $500,000)

2010-2011    Atrial Substrate Modification with Aggressive Blood Pressure Control to Prevent Atrial
    Fibrillation
    Principal Applicants:  R. Parkash, G. A. Wells
    Co-applicants:  J. Healey, J. Sapp, J-C. Tardif
    Canadian Institutes of Health Research  - Strategy on Patient Oriented Research Program (SPOR)
    Funding:  $100,000    

2010-2011    The Safety of Biologics for Musculoskeletal Conditions:  A Systematic Review and Network Meta-Analysis
    Principal Applicant:  P. Tugwell, R. Buchbinder, J. Sing, G. A. Wells
    Principal Knowledge User:  A. Lyddiatt
    Co-applicants:  R. Christensen, L. Maxwell
    Canadian Institutes of Health Research – Knowledge Synthesis Grant
    Funding:  $53,000

2010-2012    Right Ventricular Substrate Metabolism as a Predictor of Right Heart Failure in Patients with Pulmonary Arterial Hypertension
    Principal Investigator:  L. Mielniczuk
    Co-investigators:  R. Beanlands, D. Stewart, G. A. Wells, R. Davies, H. Haddad, R. de Kemp, J. Da Silva, C. Dennie
    Heart and Stroke Foundation of Canada – Grant-in-Aid
    Funding:  $132,938 (1st Year $66,469)

2010-2012     A Study to Derive a Clinical Decision Rule to Predict Short-Term Serious Outcomes in Adult Syncope Patients after Emergency Department Discharge
    Principal Co-Applicants:  V. Thiruganasambandamoorthy, I. Stiell
    Principal Co-Investigator:  G. A. Wells
    The Physicians Services Incorporated Foundation
    Funding:  $169,326 (1st Year $84,538.40)

2010-2014    Evaluation of the Safety of C-Spine Clearance by Paramedics
    Principal Applicant:  C. Vaillancourt
    Co-Applicants:  I. Stiell, G. A. Wells
    Canadian Institutes of Health Research – Operating
    Funding:  $424,140 (1st Year $99,924)

2010-2014    Ventricular Tachycardia Ablation vs Enhanced Drug Therapy in Structural Heart Disease:  The VANISH Trial
    Principal Applicants:  J. Sapp, A. Tang, G. A. Wells
    Co-Investigators:  D. Coyle, R. Parkash, W. Stevenson
    Canadian Institutes of Health Research (CIHR) – Operating RCT
    Funding:  $953,998 (1st Year $568,416)

2010-2014    A Study to Prospectively Assess the Safety and Effectiveness of the Ottawa SAH Strategy for the Investigation of Alert Patients Suspected of Having Subarachnoid Hemorrhage (Renewal – Phase III)
    Principal Applicant:  J. Perry
    Co-Applicants  C. Hohl, M. Sivilotti, I. Stiell, G. A. Wells, A. Worster
    Canadian Institutes of Health Research (CIHR) – Operating
    Funding:  $1,099,485 (1st Year $204,859)
    
2011    SR3/1045 What are the Impacts of Preschool Feeding Programmes for Disadvantaged Young Children?
    Principal Applicant:  E. Kristjansson
    Co-Applicants:  D. Francis, M. Benkhalti Jandu, S. Liberato, V. Welch, T. Greenhalgh, M. Petticrew, M. Batal, J. Krasevec, M. Arabi, G. A. Wells, E. Noonan, F. Espejo, E. Noonan
    The International Initiative for Impact Evaluation (3ie)
    Funding:  $90,000

2011    Innovative Strategies to Implement Clinical Practice Guidelines for Rheumatoid Arthritis 
    and Osteoarthritis
    Principal Applicant:  L. Brosseau, G. A. Wells
    Co-applicants:  S. Lineker, M. Bell, J. King, L. Casimiro, M. Egan, S. Poitras.            
    Canadian Institutes of Health Research (CIHR) – Knowledge Translation
    Funding:  $100,000

2011    Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis (BIODAM RA) Trial
    Principal Applicant:  W. Maksymowych, D. van der Heijde, R. Landewé
    Co-Applicants: G. A. Wells, J. Bathon, C. Bingham, V. Bykerk, M. Ostergaard, T. Kvein, M. Boers, D. Aletaha, P-P. Tak, O. Fitzgerald, C. Ritchlin, P. Mease, H. El-Gabalawy, W. Lems, D-J. van Schaardenburg, H-B. Hammer, M. Backhaus, B. Combe, G. Ferraccioli for the OMERACT group
    Abbott 
    Funding:

2011-2012     Reassessment of Anti-Platelet Therapy Using Individualized Strategies - Association of Genetic Variants to Adverse Outcomes in Clopidogrel Treated Patients after Percutaneous Coronary Intervention:  The RAPID-AGAP study
    Principal Applicant:  D. So, A. Stewart
    Co-Applicants:  R. Davies, M. Le May, J. Roberts, G. A. Wells
    Canadian Institutes of Health Research (CIHR) - Operating Grant
    Funding:  $76,244

2011-2013    Risk Stratification of Adult Emergency Department Syncope Patients to Predict Short-Term Serious Adverse Events after Discharge (RiSEDS Study)
    Principal Applicant:  V. Thiruganasambandamoorthy
    Co-applicants:  E. Lang, H. Murray, B. Rowe, R. Sheldon, M. Sivilotti, I. Stiell, G. A. Wells
    Canadian Institutes of Health Research – Operating Grant
    Funding:  $352,280 (1st Year $176,140)

2011-2015     Canadian Collaborative for Methods, Applications, and Capacity Development in Network Meta-Analysis for Drug Safety and Effectiveness
    Principal Applicant:  G. A. Wells, D. Coyle, B. Reeves, H. Schunemann, L. Thabane,
    Co-applicants:  J. Beyene, C. Cameron, T. Clifford, J. Higgins, S. Klarenbach, K. Lee, Y. Loke, M. Maher, B. Manns, G. Salanti, P. Santaguida, V. Shukla, D. Stacey, S. Sullivan and T. Trikalinos
    Canadian Institutes of Health Research (CIHR)
    Funding:  $911,520 (1st Year $200,241)

2012-2015    Improved Delivery of Cardiovascular Care (IDOCC) through Outreach Facilitation
    Principal Applicant:  C. Liddy
    Co-Applicants:  W. Hogg, S. Dahrouge, M. Taljaard, C. Deri Armstrong, G. A. Wells, 
    G. Russell
    Canadian Institutes of Health Research (CIHR)
    Funding:  $429,302 (1st Year - $143,100)

2011-2015    RAD Study Phase 2:  Validation of the Canadian HF and COPD Risk Scores for Respiratory Distress in the Emergency Department
    Principal Applicant:  I. Stiell
    Co-Applicants:  J. Perry, S. Aaron, B. Borgundvaag, R. Brison, L. Calder, B. Rowe, A. Forster, G. A. Wells
    Canadian Institutes of Health Research (CIHR)
    Funding:  $852,288 (1st Year - $213,072) 

2011-2016    A Randomized Ablation-Based Atrial Fibrillation Rhythm Control Versus Rate Control Trial in Patients with Heart Failure and High Burden Atrial Fibrillation (RAFT-AF)
    Principal Applicants:  A. Tang, R. Parkash, M. Talajic, A. Verma, G. A. Wells, 
    Co-Applicants:  M. Arnold, D. Birnie, D. Coyle, V. Essebag, J. Healey, L. Macle, G. Newton, J-L. Rouleau, A. Skanes
    Canadian Institutes of Health Research (CIHR)
    Funding: $4,941,966 (1st Year $988,393)

2012    Catalysis of New Initiatives and Collaborations to Improve Community Bystander 
    CPR Rates Team Credentials
    Principal Applicant:  C. Vaillancourt
    Co-applicants:  J. Grimshaw, J. Brehaut, M. Osmond, I. Stiell, G. A. Wells
    Canadian Institutes of Health Research (CIHR) - Knowledge Translation
    Funding:  $30,000

2012    A Network Meta-Analysis of the Cardio-Cerebrovascular Risk Associated with the Anti-Parkinsonian Combination of Levodopa/Carbidopa/Entacapone
    Principal Applicant:  G. A. Wells, L. Thabane
    Co-applicants:  C. Cameron, D. Henry, S. Kelly, Y. Loke, V. Shukla, S. Steiner
    Canadian Institutes of Health Research (CIHR)
    Funding:  $96,329

2012-2013     Syncope Clinic for Identification of Arrhythmias and those at Risk of Death among 
    Emergency Department Syncope Patients
    Principal Applicant:  V. Thiruganasambandamoorthy
    Co-Applicants:  I. Stiell, G. A. Wells, R. Davies
    The Ottawa Hospital Academic Medical Organization (TOHAMO)
    Funding:  $61,465

2012-2013    A Network Meta-Analysis of Atypical Antipsychotics for Schizophrenia
    Nominated Principal Applicant:  G. A. Wells 
    Principal Applicant:  S. Klarenbach
    Co-Applicants:  C. Cameron, R. Habib, S. Kelly, K. Lee, V. Shukla
    Canadian Institutes of Health Research (CIHR)
    Funding:  $99,866

2012-2013    A Network Meta-Analysis of Combined Pharmacologic and Behavioural Interventions for Smoking Cessation
    Nominated Principal Applicant:  G. A. Wells
    Principal Applicant:  D. Coyle
    Co-Applicants:  C. Cameron, S. Kelly, Y. Loke, A. Pipe, R. Reid, S. Sullivan
    Canadian Institutes of Health Research (CIHR)
    Funding:  $99,775

2012-2013    Early Disposition of Chest Pain Patients Using the New Troponin Assay to Improve Emergency Department Overcrowding
    Principal Investigator:  V. Thiruganasambandamoorthy
    Co-Investigators:  I. Stiell, R. Booth, G.A. Wells, R. Beanlands
    The Ottawa Hospital Academic Medical Organization (TOHAMO)
    Funding:  $99,517

2012-2015    Improving the Cardiac Arrest Diagnostic Accuracy of  9-1-1 Emergency Medical Dispatchers
    Principal Investigator:  C. Vaillancourt
    Co-investigators: L. Calder, I. Stiell, G.A. Wells
    Heart and Stroke Foundation of Ontario    
    Funding: $272,978  (1st Year - $149,984)

2012-2015    A Multicenter Prospective Cohort Study of Adverse Events Among Patients Discharged with Sentinel Cardiovascular Emergency Department Diagnoses
    Principal Applicant:  L. Calder
    Co-applicants: M. Sivilotti, I. Stiell, M. Taljaard, V. Thiruganasambandamoorthy, G. A. Wells
    Canadian Institutes of Health Research (CIHR)
    Funding:  $428,829 (1st Year - $151,140) 

2012-2015    Statistical Methods of Estimating Genetic Associations of Low Detectability
    Principal Applicant:  D. Bickel
    Co-applicants:  C. Greenwood, J. Little, R. McPherson, A. Stewart, G. A. Wells, 
    B. Zanke
    Canadian Institutes of Health Research (CIHR)
    Funding:  $280,701 (1st Year - $116,500)
    
2012-2016    Phase II:  Clinical Decision Rule for High Risk TIA Patients in the Ed
    Principal Applicant:  J. Perry
    Co-applicants:  M. Emond, C. Hohl, M. Sharma, M. Sivilotti, I. Stiell, G. A. Wells
    Canadian Institutes of Health Research (CIHR)
    Funding: $1,059,584 (1st Year - $249,983)

2013    Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients with Permanent AF (RAFT-PermAF)
    Nominated Principal Applicants:  A. Tang, 
    Principal Applicants:  D. Exner, J. Healey, R. Parkash, J-L. Rouleau, M. Talajic, G. A. Wells
    Co-Applicants:  D. Birnie, D. Coyle, A. Krahn, G. Newton, F. Philippon, D. Redfearn, B. Thibault, R. Yee
    Canadian Institutes of Health Research - Operating
    Funding:  $100,000

2013-2014    Validating a Screening Strategy to Improve the Detection of Adverse Drug Reactions in Emergency Departments
    Project Lead:  M. Sivilotti
    Co-Investigators:  C. Hohl, J. Lexchin, J. Perry, J. Singer, G. A. Wells
    Canadian Medical Protective Association (CMPA)
    Funding:  $50,000

2013-2015    CHRS Cardiac Implantable Electrical Device Surveillance System (CDSS) – A Pilot Study
    Principal Investigator:  R. Parkash
    Co-applicants: J. Healey, A. Krahn, D. Exner, R. Yee, C. Simpson, E. Crystal, P. Nery, B. Thibault, E. Stephenson, V. Essebag, F. Philippon, A. Tang , G. A. Wells
    Heart and Stroke Foundation of  Canada
    Funding:  $161,201 (1st Year - $97,481)

2013-2015    Reassessment of Anti-Platelet Therapy using InDividualized Strategies – Modifying Acute CoroNary Syndrome Algorithms based on Genetic and Demographic Evaluation:  The RAPID-MANAGE Pilot Study
    Nominated Principal Applicant:  D. So
    Principal Applicant:  J-F. Tanguay
    Co-Applicants:  C. Glover, R. McPherson, G.A. Wells, 
    Canadian Institutes of Health Research - Operating
    Funding:  $192,620 (1st Year - $96,310)

2013-2015    AMSTAR-NRS:  Helping Decision Makers Distinguish High and Low Quality Systematic Reviews of Non-Randomized Studies
    Principal Investigator:  B. Shea
    Co-Investigators:  N. Andersson, D. Henry, E. Kristjansson, D. Moher, G. A. Wells
    Canadian Institutes of Health Research – Operating
    Funding:  $148,905 (1st Year - $74,453)

2013-2016     Double Short vs Standard Exposure Duration During Cryoballoon Pulmonary Vein Isolation:  The DOSE Study
    Prinipal Investigator:  J. Andrade
    Co-applicants:  A. Tang, G.A. Wells
    Heart and Stroke Foundation of Canada – Grant-in-Aid
    Funding:  $207,911 (1st Year - $96,514)

2013-2016    A Randomized Controlled Comparison of Electrical versus Pharmacological Cardioversion for Emergency Department Patients with Recent-Onset Atrial Fibrillation and Flutter (RAFF)
    Principal Investigator:  I. Stiell
    Co-applicants:  R. Brisson, D. Birnie, B. Borgundvaag, J. Perry, G. A. Wells
    Heart and Stroke Foundation of Ontario– Grant-in-Aid
    Funding:  $255,354 (1st Year – $82,903)

2013-2016    Randomized Trial of Nordic Walking vs. Standard Cardiac Rehabilitation in Patients with
    Heart Failure
    Principal Investigator:  R. Reid
    Co-Applicants:  A. Pipe, G. A. Wells, K. Chan, L. Mielniczuk, H. Tulloch, A. Mark, J. Harris, M-L. Keast
    Heart and Stroke Foundation of Canada
    Funding:  $251,919 (1st Year - $81,912)

2014    Frequent Ventricular Premature Contractions in Heart Failure:  Prevalence and Prognosis 
    Principal Applicants:  M. Deyell, A. Tang
    Co-Applicants:  J. Sapp, G. A. Wells
    Canadian Institutes of Health Research - Operating
    Funding:  $63,008

2014-2015    Pharmacological Treatments for Rheumatoid Arthritis and Inflammatory Bowel Disease:      A Network Meta-Analysis 
    Principal Applicants:  G. A. Wells, Y. Loke
    Co-Applicants:  C. Cameron, L. Chen, S. Kelly, E. MacDonald, A. Rostom, J. Singh, 
    P. Tugwell
    Canadian Institutes of Health Research – Other:  Rapid Funding for Drug Safety and  Effectiveness Network (DSEN)
    Funding:  $175,292

2014-2015    New Oral Anticoagulants for the Treatment and Prevention of Venous     Thromboembolism:  A Systematic Review and Network Meta-Analysis
    Principal Applicant:  G. A. Wells,  B. Reeves
    Co-Applicants: C. Cameron, M. Carrier, L. Chen, J. Elliott, S. Kelly, V. Shukla, 
    S. Steiner
    Canadian Institutes of Health Research – Other:  Rapid Funding for Drug Safety and     Effectiveness Network (DSEN)
    Funding: $119,896

2014-2016    BRUISE CONTROL-2:  A Randomized Controlled Trial to Compare Continued versus     Interrupted Dabigatran at the Time of Device Surgery in Patients at High Risk of Stroke
    Principal Investigator:  D. Birnie, V. Essebag
    Co-Applicants:  J. Healey, D. Coyle, J. Sapp, A. Verma, G. A. Wells
    Heart and Stroke Foundation of Canada – Grant-in-Aid
    Funding:  $172,500 (1ST Year - $58,500)

2014-2017    Candrive Prospective Older Driver Study
    Nominated Principal Applicant:  S. Marshall
    Principal Applicants:  M. Bédard, I. Gelinas, G. Naglie, M. Porter, H. Tuokko, B. Vrkljan
    Co-Applicants: S. Gagnon, L. Li, B. Mazer, A. Myers, M. Rapoport, I. Stiell, G. A. Wells
    Canadian Institutes of Health Research (CIHR) - Operating
    Funding:  $1,386,733 (1st Year - $897,656)  

2014-2017    Improving Randomized Controlled Trials for Equity-Oriented Decisions
    Nominated Principal Applicants:  V. Welch
    Principal Applicant:  P. Tugwell
    Knowledge User:  H. White 
    Co-Applicants:  G. Grimshaw, E. Kristjansson, D. Moher, T. Pantoja, M. Petticrew, K. Pottie, B. Shea, G. A. Wells    
    Canadian Institutes of Health Research (CIHR) -     Operating
    Funding:  $220,442 (1st Year - $72,062)

2014-2017    The Effect of Statin Therapy on CFR and Markers of Inflammation in HIV Positive 
    Individuals
    Principal Applicants:  P. MacPherson, G. Dwivedi
    Co-Applicants:  R. Beanlands, J. Angel, K. Chan, R. deKemp, G. A. Wells, 
    V. Corrales-Medina, C. Tremblay
    The Ontario HIV Treatment Network (OHTN) - Operating
    Funding:  $374,252

2014-2017    Cardiovascular Biomarker Translation (CBT) Program
    Academic Project Leader:  P. Liu, Gabriela Bucklar-Suchankova
    User Organization Project Leader:  C. Zaugg
    Methodology Expert:  G. A. Wells
    Project Team Members:  U. Wienhues-Thelen, M. Felker, A. Ziegler, L. Mielniczuk
    Genome Canada - $1,953,663; Roche - $2,584,345; 
    University of Ottawa Heart Institute - $1,366,654
    Funding:  $5,904,662

2014-2019    Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients with Permanent AF (RAFT-PermAF)
    Nominated Principal Applicant:  A. Tang
    Principal Applicant:  D. Exner, J. Healey, R. Parkash, M. Talajic, G. A. Wells
    Co-Applicants:  D. Birnie, D. Coyle, V. Essebag, A. Krahn, G. Newton, F. Philippon, D. Redfearn, B. Thibault, Yee, R., 
    Canadian Institutes of Health Research (CIHR) - Operating
    Funding:  $3,265,595 (1st Year - $633,094)

2014-2019    Methods and Applications Group for Indirect Comparisons
    Principal Applicant:  S. Straus, A. Tricco, B. Hutton, D. Moher, G. A. Wells
    Co-Applicants:  B. Hemmelgarn, S. Majumdar, D. Stacey, D. Coyle, et al
    Canadian Institutes of Health Research – Drug Safety and Effectiveness Network     (DSEN) collaborating Centre for Network Meta-Analysis 
    Funding:  $6,998,765 (1st Year - $816,523)

2014-2019    Canadian Arrhythmia Network (CANet) - Network of Centre of Excellence (NCE)
    Principal Applicants:  A. Tang (Nominated),  G. A. Wells, B. Sheldon
    Natural Sciences and Engineering Research Council of Canada (NSERC) $14,374,000
    Social Sciences and Humanities Research Council (SSHRC) $2,951,000
    Canadian Institutes of Health Research (CIHR) $8,937,024)
    Funding:  $26,262,024

250 2015    Antimicrobial Resistance (AMR)
    Principal Investigator:  G. A. Wells
`    Co-Investigators:  S. Kelly, D. Beking, V. Shukla
    World Health Organization (WHO) - Contract
    Funding:  $16,660  (1st Year - $14,000 US)

2015-2016    The Safety and Efficacy of Femoral Access Versus Radial Access for Primary PCI in 
    STEMI (The SAFARI-STEMI Trial)
    Principal Applicants:  M. Le May, G. A. Wells
    Co-Applicants:  D. Coyle, A. Quraishi    
    Canadian institutes of Health Research (CIHR) – Transitional Operating
    Funding:  $100,000

2015-2016    Neurocognitive Outcomes after Out-of-Hospital Cardiac Arrest
    Principal Applicants:  H. Tulloch, B. Collins, A. Smith
    Co-Applicants: M. Le May, G.A. Wells
    Canadian Institutes of Health Research – Transitional Operating
    Funding:  $100,000

2015-2016    Neurocognitive Outcomes after Out-of-Hospital Cardiac Arrest
    Principal Investigator:  H. Tulloch, B. Collins
    Co-Applicant:  T. McHugh, M. Le May, L. Duchesne, B. Quinian, 
    A-S. Nesrine, G.A. Wells
    Heart and Stroke Foundation of Canada – Grant-in-Aid
    Funding:  $149,644 (1st Year – $52,090)

2015-2016    Cardiac Sarcoidosis Multicenter Prospective Cohort
    Principal Applicants:  D. Birnie (Nominated), R. Beanlands, P. Nery
    Co-Applicants:  S. Aaron, S. Chakrabarti, R. De Kemp, V. Essebag, M. Friedrich, 
    L. Gula, A. Ha, J. Healey, T. Hruczkowski, P. Liu, R. Quinn, L. Rivard, J. Sapp, A. Tang, 
    G. A. Wells, G. Wisenberg
    Canadian Institutes of Health Research (CIHR) – Transitional Operating
    Funding:  $100,000

2015-2018    Myocardial Blood Flow Reserve and Vascular Inflammation in Psoriasis & Psoriatic 
    Arthritis:  Response to Biologics
    Printipal Applicant:  G. Dwivedi
    Co-Applicants:  R. Beanlands, B. Chow, R. De Kemp, S. Glassman, J. Karsh, 
    G. A. Wells
    Canadian Institutes of Health Research (CIHR) – Operating
    Funding:  $315,576 (1st Year - $105,192)

2015-2018    Reassessment of Anti-Platelet Therapy using InDividualized Strategies – Ticagrelor in 
    Patients with Acute Coronary Syndromes Treated by Coronary Artery Bypass Graft 
    Surgery – A Pharmacodynamic and Clinical Study to Decrease Bleeding Risks and 
    Ischemic Complications – The RAPID-TITRATE CABG Study.
    Principal Applicant:  D. So, F. Rubens, J-F. Tanguay
    Co-Applicants:  V. Chan, A. Chong, J. Dupuis, B. Hibbert, M. Lordkipanidzé,
     L. Perrault, M. Ruel,  G. A. Wells
    Canadian Institutes of Health Research (CIHR) – Operating
    Funding:  $512,179 (1st Year - $170,726

Staff 

Dr. George A. Wells, Director, Cardiovascular Research Methods Centre

Annie Bai, Research Assistant 
Jordan Bernick, Junior Biostatistician
Li Chen, Biostatistician
Jesse Elliott, Research Assistant
Anne Gray, Administrative Assistant
Alomgir Hossain, PhD, Biostatistician
Shu-Ching Hsieh, Research Assistant
Amy Johnston, Research Assistant
Shannon Kelly, Study Coordinator
Wenfei Liu, Research Trainee
Nazmun  Nahar, Clerk
My-Linh Tran, Database Manager


Janine Ryan
Patricia Theoret-Patrick

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