PET Research Radiochemistry

The mission of the UOHI PET Research Radiochemistry Laboratory is to provide the UOHI, the University of Ottawa and Greater Ottawa region with an onsite core facility that can offer a bench to bedside production/service, providing quality PET Radiopharmaceuticals for research projects in radiochemistry, targetry, animal-models and human imaging.

Our goal is to produce novel and established PET Radiopharmaceuticals for innovative research to help understand and guide novel therapies in cardiovascular, kidney, diabetes, oncology and neuroscience diseases.

Our lab offers the capability for research on basic radiochemistry to develop novel PET probes with the ultimate goal of translational work in humans to address scientific questions via PET imaging.

Services

Radiotracer Application in Cardiology Other Potential Applications

13N-Ammonia

Myocardial blood flow

Animal and human MBF quantification

Renal perfusion

18F-NaF

 

Arterial calcific/plaque imaging

atherosclerosis

Bone cancer

18F-FTHA

Free fatty acid uptake

PAH patients and animal models

Other animal models such as MLIP +/+, +/-, -/- mice

Skeletal muscle anomalies

11C-HED

SNS innervations

Sleep apnea study

Heart failure

Atrial fibrillation

Evaluation of neuronal integrity (examination of tumours of the sympathetic nervous systems)

11C-Acetate

MBF

Myocardial oxygen consumption

Myocardial perfusion

Oxidative metabolism

Cardiac efficiency

Renal perfusion

Prostate cancer
Hepatocellular carcinoma (HCC)

Renal cell carcinoma (RCC)

Bladder carcinoma

Brain tumours

Multiple myeloma

MBF in kidney

11C-Rolipram

PDE4 ligand

Heart failure

 

18F-FPyKYNE-Losartan

AT1 receptor uptake

Heart failure, hypertension

Diabetes, renal diseases

18F-HFB

Cell regenerative therapy

Cell regenerative therapy

Direct Cell Labelling

18F-FPyKYNE-c(RGDyK)

αVβ3 Integrin Receptor

Inflammation

Inflammation

11C-methyl-Hydroxyfasudil

Rho-Kinase ligand

Inflammation, heart failure, hypertension

Diabetes

11C-Carfentanil

 

Opioid Receptor ligand

Mental disorders

11C-Raclopride Quantification of Dopamine-D2 receptors
Neuropsychiatric disorders
Mental disorders
18F-FEOBV Neurodegenerative disease
Alzheimer disease
Dementia

User Fee Schedule

Prices in effect as of July 01, 2023.

Pre-Clinical Imaging and
Human Clinical and Large Animal Imaging Research 
  External User Internal User Pilot studies **
  Complete synthesis
NaF

620

600 550
NH3

350

320 220
Acetate

800

770 670
HED

1,150

1,100 1,000
LMI1195 1,350 1,320 1,200

Raclopride

1,200 1,100 1,000
FEOBV 1,700 1,420 1,320
F-18 Aldehyde / BF3 230 230 230
F-18 200
(15 min beam time. $50 for additional unit)
180 / unit
(15 min beam time. $50 for additional unit)
180
(15 min beam time. $50 for additional unit)
C-11 MeI 300 300 180
C-11 CO2 30 / unit
(15 min beam time)
30 / unit
(15 min beam time)
30 / unit
(15 min beam time)
Radiotracer Module Training $60 / hour $60 / hour $60 / hour
  • * The fee will increase by 1.5% each year
  • ** Pilot = maximum 10 doses
  • a = beaming/synthesis performed by Radiochemistry staff (Materials are not included)
  • b = beaming/synthesis performed by PI staff

List of Equipment

  • Siemens CTI Eclipse HP/RD Hybrid Cyclotron
  • GE Tracerlab MX (coincidence)
  • GE Tracerlab FX F-N
  • GE Tracerlab FX C-Pro
  • CTI ASM Methylation Module
  • CTI ASM Methyl Iodine Acetate Module
  • Siemens Explora FDG4
  • MediSMARTS Radiation Monitoring System
  • Von Gahlen Hot cells
  • SRI Gas Chromatography System
  • Radio-TLC Imaging Scanner
  • Agilent HPLC
  • Agilent GC
  • Multi-Channel Analyzer (MCA)
  • Laminar Flow Hoods and Biological Safety Cabinets
  • Capintec Dose Calibrators
  • Mettler Toledo Balance
  • Millipore Water Deionizer
  • Analytical and Semi-preparative HPLC Systems (Waters)
  • Rotary Evaporator
  • Perkin Elmer GC
  • Turbomax Auto Headspace Sampler

Contact

For service requests and more information please contact:

Dr. Christian Umeobika, PhD
Manager, Radiochemistry Laboratory
UUmeobika@ottawaheart.ca

Facility Staff Members

Dr. Christian Umeobika, PhD
Manager, Radiochemistry Laboratory
Develops, produces and analyses novel and established PET Radiopharmaceuticals and oversees lab operations.
UUmeobika@ottawaheart.ca

Elmi Mohamed
Radiochemistry Technologist
EMohamed@ottawaheart.ca
Produce and analyze novel and established PET Radiopharmaceuticals.

Joseph Ro
Radiochemistry Technologist
DRo@ottawaheart.ca
Produce and analyze novel and established PET Radiopharmaceuticals.

Hugo Nolasco
Radiochemistry and Cyclotron Engineer
HNolasco@ottawaheart.ca
Maintains and services all lab equipment.

Nadia Zaid
RSO
nzaid@toh.ca
Regulates radiation safety.

Linda Garrard
Business Manager
lgarrard@ottawaheart.ca
Invoicing, administration, business.

Rob Beanlands, MD
Medical Doctor
rbeanlands@ottawaheart.ca
Responsible of PERs administered to humans.