Cardiovascular Electrophysiology

The Cardiovascular Electrophysiology team is focusing on mechanistic studies of arrhythmogenic heart disease, with the hope of developing novel therapies for cardiac arrhythmias. Techniques used include somatic gene transfer, cellular electrophysiology, isolated organ and whole-animal studies, as well as cellular and molecular biology techniques.

Publications 

Selected publications:

  1.  Liang W, Lu A, Davis DR. Induced Pluripotent Stem Cell-Based Treatment of Acquired Heart Block: The Battle for Tomorrow Has Begun! Circulation:  Arrhythmia and Electrophysiology. 2017 May;10(5):e005331. doi: 10.1161/CIRCEP.117.005331.
  1.  Hamel V, Cheng K, Liao S, Lu A, Zheng Y, Chen Y, Xie Y, Liang W. De Novo Human Cardiac Myocytes for Medical Research: Promises and Challenges. Stem Cells International. 2017;2017:4528941. doi: 10.1155/2017/4528941.
  1. Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28;166(3):624-36. [Featured article on the cover]
  1. Liang W, Cho HC and Marbán E. Wnt signaling suppresses voltage-gated sodium channel expression in postnatal rat cardiomyocytesJournal of Physiology, 2015;593:1147-1157
  2. *Ionta V, *Liang W, Kim EH, Rafie R, Giacomello A, Marbán E, Cho HC. Shox2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing abilityStem Cell Reports, 2015;4:129-142. *equal contribution
  3. Xie Y, Ibrahim A, Cheng K, Wu Z, Liang W, Malliaras K, Sun B, Liu W, Shen D, Cho HC, Li T, Lu L, Lu G and Marbán E. Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells in cardiac repairStem Cells, 2014;32:2397-2406
  4. *Liang W, *Huang L, Zhao D, He JZ, Sharma P, Gramolini AO, Ward ME, Cho HC and #Backx PH. Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cellsJournal of Hypertension, 2014;32:318-330. *equal contribution
  5. *Kapoor N, *Liang W, Marbán E and Cho HC. Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18. Nature Biotechnology, 2013;31:54-62. *equal contribution. [cited by 141; Journal Impact Factor: 41.5]
  6. *Jadhav A, *Liang W, Bastin G, Kroetsch J, Balsevich J, Heximer S, Backx PH and Gopalakrishnan V. L-tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage-operated calcium channels in smooth muscleBritish Journal of Pharmacology, 2012; 166: 232-242. *equal contribution
  7. Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME and Backx PH. Role of PI3Kα, PKC and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractilityHypertension, 2010;56:422-429.  Editorial in Hypertension, 2010;56:349-350.
  8. Liang W, Ray JB, He JZ, *Backx PH and Ward ME. Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cellsHypertension, 2009;54:286-293.  *corresponding author.
  9. Tang G, Wu L, Liang W and Wang R. Direct stimulation of KATP channels by endogenous and exogenous hydrogen sulphide in vascular smooth muscle cellsMolecular Pharmacology, 2005;68:1757-1764. [cited by 255]
Positions Available 

We are recruiting highly motivated students and postdoctoral fellows to investigate the mechanisms of cardiac arrhythmia and vascular diseases, as well as to develop novel cell- and gene-based therapies.

Email: wliang@ottawaheart.ca, wlian3@uottawa.ca

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