Pre-Clinical Imaging

The Pre-Clinical Imaging (PCI) Core provides access to state-of-the-art molecular, functional and anatomic imaging modalities such as micro PET, SPECT-CT, ECHO, and autoradiography for small-animal imaging. Large-animal imaging is also available. In addition, the PCI core provides standard and image-based biodistribution assessment. Imaging is performed by a dedicated animal-imaging technologist and assistance with image analysis is also available.

The PCI core is nationally and internationally recognized, providing research and contract pre-clinical imaging services to academia, industry, non-profit and drug-development CROs, with particular focus on cardiovascular molecular imaging. In addition, this core provides a multidisciplinary training environment for trainees from around the world, making this core facility a translational imaging resource for novel, scientific investigation thus directly contributing to key UOHI strategic priorities.

Services

  • Echocardiography
  • SPECT
  • PET
  • CT
  • Biodistribution
  • Autoradiography
  • Pre-clinical image analysis
  • Animal Care and Ethics protocol review and budget costing for grants

Contact

For service requests and more information please contact:

Co-Director: Rob deKemp. PhD
Email: radekemp@ottawaheart.ca 
613-761-4275

Co-Director: Glenn Wells, PhD
Email: gwells@ottawaheart.ca
613-798-5555 x18175

Recent Publications Associated with PCI Core:

  1. R.G.Wells, L. Wei, J. Lockwood, Y. Duan, B. Marvin, R. Timmins, K. Soueidan, C. Bensimon, P. Fernando,T.D. Ruddy, “Flow-dependent uptake of I-123-CMICE-013, a novel SPECT perfusion agent, compared to standard tracers”. J Nucl Med 2015; 56:764-770.
  2. J.H. Strydhorst, R.G. Wells, “Effects of CT-based attenuation correction on rat microSPECT images on relative myocardial perfusion and quantitative tracer uptake”. Med Phys 2015; 42(4):1818-1824.
  3. R.G. Wells, R. Timmins, R. Klein, J. Lockwood, B. Marvin, R.A. deKemp, and T.D. Ruddy, “Dynamic SPECT measurement of Absolute Myocardial Blood Flow in a Porcine Model”. J Nucl Med 2014; 55:1685-1691.
  4. J.H. Strydhorst, R.G. Wells, “Quantitative Measurement of In Vivo Tracer Concentration in Rats with Multiplexed Multi-pinhole SPECT”. IEEE Trans Nucl Sci 2014; 61(3):1136-1142.
  5. R. Galea, C. Ross, R.G. Wells, “Reduce, reuse and recycle: A green solution to Canada’s medical isotope shortage”. Appl Radiat Isot. 2014; 87:148-51.
  6.  Y. Duan, J. Lockwood, L. Wei, C. Hunter, K. Soueidan, C. Bensimon, P. Fernando, R.G. Wells, T.D. Ruddy, “Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats”. Eur J Nucl Med Mol Imaging Research 2014; 4(1): 16 (12 pages).
  7. L. Wei, C. Bensimon, X. Yan, J. Lockwood, W. Gan, R.G. Wells, Y. Duan, P. Fernando, B. Gottlieb, W. Mullett, T.D. Ruddy, ”Characterization of four isomers of 123I-CMICE-013: a Potential SPECT Myocardial Perfusion Imaging Agent”. Bioorganic and Medicinal Chemistry 2014; 22(7): 2033-2044.
  8. P. Fernando, X. Yan, J. Lockwood, Y. Duan, L.Wei, R.G.Wells, C. Bensimon,W.M.Mullett and T.D. Ruddy, “Toxicological evaluation of a rotenone derivative in rodents for clinical myocardial perfusion imaging”. Cardiovasc Toxicol 2014; 14:170-182.
  9. S.L. Thorn, R.A. deKemp, T. Dumouchel, R. Klein, J.M. Renaud, R.G. Wells, M. Gollob, R.S. Beanlands, J.N. DaSilva, ” Repeatable Non-Invasive Imaging of FDG PET in the Mouse Myocardium: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model”. J. Nucl. Med. 2013;54(9):1637-44.
  10. L. Wei, C. Bensimon, J. Lockwood, X. Yan, P. Fernando, R.G. Wells, Y. Duan, Y.X. Chen, J. R. Redshaw, P.A. Covitz, T.D. Ruddy, ”Synthesis and Characterization of 123I-CMICE-013: a Potential SPECT Myocardial Perfusion Imaging Agent”. Bioorganic and Medicinal Chemistry 58 (2013) 2903-2911.
  11. R. Galea, R.G. Wells, C.K. Ross, J. Lockwood, K. Moore, J.T. Harvey, G.H. Isensee, ”A comparison of rat SPECT images obtained using 99mTc derived from 99Mo produced by an electron accelerator with that from a reactor”. Phys. Med. Biol. 58 (2013) 27372750.
  12. J. Strydhorst, F. Leenen, T.D. Ruddy, R.G.Wells, “Reproducibility of serial left ventricular perfusion, volume, and ejection fraction measurements using multiplexed multi-pinhole SPECT in normal rats and following myocardial infarction”. J. Nucl. Med. 52, 1285-1292 (2011).

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