Dr. Leenen’s current areas of research focus on two areas: Brain mechanisms determining sympathetic hyperactivity in salt-sensitive hypertension and congestive heart failure Genetic basis of salt-sensitive hypertension
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An increased level of low-density lipoprotein (LDL) cholesterol, the so-called “bad cholesterol”, in the circulation is a primary risk factor for the development of cardiovascular heart disease. Our lab’s primary research interests are cellular and molecular mechanisms that regulate cholesterol...
Right heart failure (HF) is one of the most important predictors of outcomes in cardiac disease and pulmonary hypertension. Despite this, there is little known about the mechanisms underlying right HF, and currently there are no therapies that directly and selectively target the right heart. The...
The Metaresearch and Open Science Program is interested in a range of topics including the implementation of open science, the reporting quality of research, data management and sharing best practices, research reproducibility, and patient engagement in research. The team is comprised of members...
Research in our lab includes basic science radiochemistry and translational radiotracer development. Our overall goal is discovery and refinement of tools for molecular imaging, principally by positron emission tomography (PET). PET allows for non-invasive, quantitative and dynamic imaging of...
The Molecular Signaling Laboratory focuses on the effects of two important and interrelated aspects of heart development: molecular regulation of myocyte differentiation and regeneration. The first research objective is the elucidation of the role that A-type lamins play in cellular differentiation...
Our research program is very patient focused. In general we have two criteria when considering starting a new project. Firstly is there an important clinical research question to be answered? Secondly does our group have the necessary experience, skills, resources and collaborations to be able to...
The Regenerative Therapies Laboratory develops innovative methods to restore needed blood flow to patients with severely compromised hearts while minimizing the physical impact of surgery. Our research includes the investigation of stem and/or progenitor cell therapy for a regenerative approach to...
Genetic factors account for approximately 50% of heart disease risk. Understanding the genetics of heart disease is a major research focus in cardiovascular medicine. Knowledge of relevant genes and their function will extend our knowledge of the biological pathways that lead to heart disease. It...
A revolutionary change in the design of cardiac SPECT cameras is underway and the Heart Institute is the first site in Canada to obtain advanced equipment. This marks the first major change in design since the 1960s and greatly improves image quality. New technology means that many more lenses in...
Population Health Research Program in Heart Failure and Cardiovascular Interventions (Team Soleil) Team Soleil’s research program is based on heart failure and long-term outcomes after cardiovascular interventions. The scope of work encompasses precision medicine, sex and gender epidemiology, as...
Derek So, MD, currently leads the RAPID research team, which consists of a group of interventional cardiologists, cardiovascular surgeons, anesthesiologists, pharmacologists, basic scientists and epidemiologists with a common interest in pursuing research in the personalization of anti-platelet...