Population Health Research Program in Heart Failure and Cardiovascular Interventions (Team Soleil)
Team Soleil’s research program is based on heart failure and long-term outcomes after cardiovascular interventions. The team focuses on sex and gender epidemiology, as well as precision medicine and patient-oriented outcomes.
Specific projects include establishment of novel predictive approaches for perioperative right ventricular failure and acute kidney injury, determination of personalized perioperative hemodynamic goals to prevent complications in cardiac surgical patients, improving the outcomes of ambulatory and surgical patients with heart failure, and finding solutions to sex-based disparities in access to heart failure care; through a mixture of interventional and observational study designs and integration of institutional and large administrative databases.
- Influence of sex on cardiac referral, quality indicators and outcomes in heart failure care in Ontario and the Champlain LHIN
- Development and application of patient-defined outcomes after revascularization
- Long-term outcomes after revascularization and valvular surgery
- Comparative effectiveness of surgical and percutaneous procedures
- Left ventricular functional recovery
- Utilization of novel biomarkers and hemodynamic markers in prediction of right ventricular failure and acute kidney injury in patients undergoing major cardiac surgery
- Hemodynamic predictors of right ventricular failure in cardiac surgical patients
- Defining personalized perioperative hemodynamic targets to prevent complications
- Frailty and prehabilitation
Selected publications (up to 10):
1. Sun LY, Wijeysundera DN, Tait G, Beattie WS. Association of Intraoperative Hypotension with Acute Kidney Injury after Elective Noncardiac Surgery. Anesthesiology. Published online July 16, 2015. doi:10.1097/ALN.000000000000076.
2. Preoperative pulmonary function testing decreased after ACP guidelines - a population- based study. Interview with MedicalResearch.com on June 12, 2015.
3. Sun LY, Gershon AS, Ko DT, Thilen SR, Yun L, Beattie WS, Wijeysundera DN. Trends of Pulmonary Function Testing before Non-Cardiothoracic Surgery in a Population-Based Cohort. JAMA Internal Medicine. Published online June 8, 2015. doi:10.1001/jamainternmed.2015.2087.
4. Sun L, Boodhwani M, Baer H, McDonald B. The association between tracheostomy and sternal wound infection in postoperative cardiac surgery patients. Can J Anaesth. 2013 Jul;60(7):684-91.
5. Barra L, Ha A, Sun L, Fonseca C, Pope J. Efficacy of biologic agents in improving the Health Assessment Questionnaire (HAQ) score in established and early rheumatoid arthritis: a meta-analysis with indirect comparisons. Clin Exp Rheumatol. 2014 Jan 24.
6. Murphy MJ, Tichauer KM, Sun L, Chen X, Lee TY. Mean transit time is an index of cerebral perfusion pressure in experimental systemic hypotension. Physiological Measurement. 2011 Apr;32(4):395-405.