Clinical Trials

Today’s research is tomorrow’s treatment! This is particularly true here at the University of Ottawa Heart Institute, where research spans from the laboratory to the patient’s bedside and back.

At any given time, the Heart Institute may have up to 200 active clinical trials, in various stages of the lifecycle of a study. Some projects are conducted only here at the Institute, while others are large national or international projects; some are led by us and others we participate in as a site. Thousands of patients and, in some cases, healthy volunteers, participate in our studies annually. Currently, we have 50 Scientists and Clinician Investigators leading research trials on site.

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Current Clinical Trials at the Heart Institute

Status Study
Recruiting Blood Flow Reserve: Effects After Training With Heavy Inspiratory Exercises
Recruiting Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial
  • Conditions: Non-melanoma Skin Cancer,   Carcinoma, Squamous Cell,   Carcinoma, Basal Cell,   Keratinocyte Carcinoma
  • Sponsor: Women's College Hospital,   Canadian Institutes of Health Research (CIHR),   University Health Network, Toronto,   NOW Foods
Recruiting Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
  • Interventions: Diagnostic Test PET scan
Recruiting Active-control Randomised Trial Comparing 4-factor Prothrombin Complex Concentrate With Frozen Plasma in Cardiac Surgery
Recruiting COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation
  • Sponsor: Ottawa Hospital Research Institute,   Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network,   Canadian Institutes of Health Research (CIHR)
Recruiting Catheter Ablation Versus Radio-Ablation for Ventricular Tachycardia: a Randomized Controlled Trial
Recruiting Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
  • Conditions: Heart Diseases,   Coronary Artery Disease,   Coronary Artery Bypass Grafting
  • Sponsor: Weill Medical College of Cornell University,   New York Presbyterian Hospital,   Sunnybrook Health Sciences Centre,   Cedars-Sinai Medical Center,   Columbia University,   Duke University
Recruiting Pilot Randomized Clinical Trial of Live-streamed Cardiovascular Rehabilitation
Recruiting Effect of Colchicine on the Progression of Aortic Valve Stenosis - A Pilot Study
  • Conditions: Aortic Stenosis,   Inflammation
Recruiting CardiAMP™ Cell Therapy for Heart Failure Trial
Recruiting Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
  • Conditions: Stroke,   Patent Foramen Ovale
Recruiting Evaluating the Use of a Remote Telehome Monitoring Hypertension Program for Patients Receiving Virtual Care
  • Interventions: Behavioral Telehome Monitoring
Recruiting Feasibility of High-Intensity Interval Nordic Walking in Patients With Coronary Artery Disease
Recruiting Patient Engagement Study to Evaluate the Use of Biological Therapies for Cardiac Arrhythmias
Recruiting Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock
  • Conditions: Cardiogenic Shock,   Mitral Regurgitation
Recruiting CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock
Recruiting An Evaluation of the Talk Test for Exercise Prescription for Home-Based Cardiac Rehabilitation
Recruiting AERIAL Trial: Antiplatelet Therapy in Heart Transplantation
  • Conditions: Cardiac Allograft Vasculopathy,   Heart Transplant
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting QOL Improvement After Cardioversion of Persistent AF (QOL-CAFRCT)
Recruiting Randomized Ablation-based AF Rhythm-control Versus Rate-control in Patients With HF and High-burden AF Extend
  • Conditions: Atrial Fibrillation,   Heart Failure
  • Interventions: 
Recruiting Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation
  • Conditions: Atrial Fibrillation,   Persistent Atrial Fibrillation,   Paroxysmal Atrial Fibrillation
Recruiting Improving Goal Directed Medical Therapy for Device Clinic Patients With Reduced EF at UOHI: a QI Initiative (VIGILANT)
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Novartis,   Servier,   AstraZeneca
Recruiting A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery
Recruiting REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial
  • Conditions: Mitral Valve Insufficiency,   Coronary Artery Disease
Recruiting Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)
  • Conditions: Nonvalvular Atrial Fibrillation,   Severe Degenerative Mitral Regurgitation
  • Interventions: Procedure MitraClip TMVR and Watchman LAAO
Recruiting Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure
  • Conditions: Hemorrhage,   Urgent Surgery,   Invasive Procedure
  • Interventions: Drug Bentracimab (PB2452) Infusion
Recruiting Exercise Training in Women With Heart Disease
  • Conditions: Cardiovascular Diseases,   Coronary Heart Disease
  • Interventions: Behavioral Exercise
Recruiting Amplatzer Amulet LAAO vs. NOAC
  • Conditions: Atrial Fibrillation,   Stroke,   Bleeding
Recruiting MitraClip REPAIR MR Study
Recruiting Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
  • Conditions: Mitral Regurgitation,   Mitral Insufficiency,   Mitral Valve Insufficiency,   Cardiovascular Diseases,   Valve Disease, Heart,   Heart Valve Diseases,   Functional Mitral Regurgitation,   Degenerative Mitral Valve Disease
Recruiting Cytisine Compared to Combination NRT in Relapsed Smokers
  • Conditions: Smoking Cessation,   Coronary Artery Disease
Recruiting Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
Recruiting Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
  • Conditions: Atrial Fibrillation,   Stroke,   Bleeding
  • Sponsor: Icahn School of Medicine at Mount Sinai,   National Heart, Lung, and Blood Institute (NHLBI),   Vanderbilt University Medical Center
Recruiting TRILUMINATE Pivotal Trial
  • Interventions: Device Tricuspid valve repair
Recruiting Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
  • Conditions: Ascending Aortic Aneurysm Enlargement,   Ascending Aorta Aneurysm
  • Interventions: Procedure Thoracic Aortic Surgery
  • Sponsor: Ottawa Heart Institute Research Corporation,   University of Calgary
Recruiting The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments
  • Conditions: Nicotine Dependence, Cigarettes,   Nicotine Withdrawal
  • Interventions: Behavioral Quit Card Intervention (QCI)
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Canadian Study of Arterial Inflammation in Patients With Diabetes and Vascular Events: EvaluatioN of Colchicine
  • Conditions: Cardiovascular Diseases,   Atherosclerosis,   Inflammation,   Diabetes
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting The Effect of High-Intensity Interval Training on Glucose Variability and Atrial Fibrillation Symptoms
  • Conditions: Atrial Fibrillation,   Type 2 Diabetes
  • Interventions: Behavioral High-intensity interval training + standard care
Recruiting Healing Hearts Together: Evaluating a Couples-based Intervention to Improve Health Outcomes
  • Interventions: Other Healing Hearts Together
Recruiting Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus
Recruiting Effect of a Hybrid Rehabilitation Program on Walking, Quality of Life & Cardiovascular Risk in People With PAD
  • Interventions: Behavioral HY-PAD
  • Sponsor: Ottawa Heart Institute Research Corporation,   AFP Innovation Fund
Recruiting Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation (Exercise-AF)
  • Conditions:Persistent or Permanent Atrial Fibrillation (Exercise-AF)
  • Interventions:Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks. Participants will attend on-site high-intensity interval training two times weekly for 12 weeks.
Recruiting Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion
  • Interventions: Drug Rivaroxaban 15 MG Oral Tablet [Xarelto]
Recruiting Cardiac Sarcoidosis Randomized Trial
  • Conditions: Cardiac Sarcoidosis,   Sarcoidosis
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
  • Sponsor: Ottawa Heart Institute Research Corporation,   London Health Sciences Centre,   Heart Center Leipzig - University Hospital,   Fortis Escorts Heart Institute,   The Methodist Hospital Research Institute,   Carolinas Medical Center,   Gundersen Lutheran Health System,   Jilin Heart Hospital,   Far Eastern Memorial Hospital,   Medtronic,   Apollo Hospitals Enterprise Limited,   Fresno Heart and Surgical Hospital,   Ichinomiya-Nishi Hospital
Recruiting Peer Support for Women With Heart Disease: Women@Heart
  • Conditions: Coronary Heart Disease,   Women's Health
  • Interventions: Behavioral Women@Heart Program
Recruiting Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation
Recruiting Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation
  • Interventions: Procedure Catheter ablation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Heart and Stroke Foundation of Canada
Recruiting Biomarker Guided Discharge of Heart Failure Patients
  • Interventions: Other Biomarker guided discharge algorithm
  • Sponsor: Peter Liu,   Genome Canada,   Roche Diagnostics,   Ottawa Heart Institute Research Corporation
Recruiting Sub-Clinical Atrial Fibrillation Biomarker Study
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Population Health Research Institute,   Genome Canada,   Bristol-Myers Squibb,   Pfizer,   Medtronic,   Canadian Institutes of Health Research (CIHR)
Recruiting Comparing Hypothermic Temperatures During Hemiarch Surgery
  • Interventions: Procedure Hypothermic circulatory arrest
Recruiting Predicting Development of SCAF in Device Patients
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Genome Canada
Recruiting Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training
Recruiting Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
  • Sponsor: Laval University,   University Hospital, Brest
Recruiting Cardiac FDG PET Viability Registry
  • Conditions: Heart Failure,   Ischemic Heart Disease,   Myocardial Dysfunction
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care
Recruiting Cardiac Sarcoidosis Multi-Center Prospective Cohort
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Canadian Institutes of Health Research (CIHR)

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