Clinical Trials

Today’s research is tomorrow’s treatment! This is particularly true here at the University of Ottawa Heart Institute, where research spans from the laboratory to the patient’s bedside and back.

At any given time, the Heart Institute may have up to 200 active clinical trials, in various stages of the lifecycle of a study. Some projects are conducted only here at the Institute, while others are large national or international projects; some are led by us and others we participate in as a site. Thousands of patients and, in some cases, healthy volunteers, participate in our studies annually. Currently, we have 50 Scientists and Clinician Investigators leading research trials on site.

For more information please contact JoinAStudy@ottawaheart.ca.

Current Clinical Trials at the Heart Institute

Status Study
Recruiting INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure
  • Conditions: Heart Failure,   Myocardial Infarction
  • Sponsor: Brigham and Women's Hospital,   National Heart, Lung, and Blood Institute (NHLBI),   University of Wisconsin, Madison,   University of Toronto,   Boston VA Research Institute, Inc.,   Patient-Centered Outcomes Research Institute
Recruiting Atrial Fibrillation Trial to Evade Recurrence: effectS of Hiit Before electrO-Cardioversion for 3-weeKs
  • Interventions: Behavioral High-intensity interval training
  • Sponsor: Ottawa Heart Institute Research Corporation,   Cardiac Arrhythmia Network of Canada
Recruiting Sleep to Your Heart's Content - Insomnia Intervention for Cardiac Patients
  • Conditions: Insomnia,   Cardiovascular Diseases
  • Interventions: Behavioral CBT-I
Recruiting The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension
Recruiting Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation
Recruiting Early Post Transplant Cardiac Allograft Vasculopathy
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Toronto General Hospital
Recruiting Peer Support for Women With Heart Disease: Women@Heart
  • Conditions: Coronary Heart Disease,   Women's Health
  • Interventions: Behavioral Women@Heart Program
Recruiting PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients
  • Conditions: Coronary Artery Disease,   Valvular Heart Disease
Recruiting AdaptResponse Clinical Trial
Recruiting A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
  • Conditions: Coronary Disease,   Coronary Stenosis
  • Sponsor: Stanford University,   VZW Cardiovascular Research Center Aalst,   Catharina Ziekenhuis Eindhoven,   Golden Jubilee National Hospital,   University of California, Irvine,   Medtronic,   St. Jude Medical,   Genae,   King's College Hospital, London,   Houston Methodist DeBakey Heart and Vascular Center, Houston
Recruiting Spironolactone Therapy in Chronic Stable Right HF Trial
  • Conditions: Chronic Right-Sided Heart Failure,   Pulmonary Arterial Hypertension,   Pulmonary Hypertension, Primary, 2,   Pulmonary Hypertension, Primary, 3,   Pulmonary Hypertension, Primary, 4,   Cardiomyopathy Right Ventricular
Recruiting Biomarker Guided Discharge of Heart Failure Patients
  • Interventions: Other Biomarker guided discharge algorithm
  • Sponsor: Peter Liu,   Genome Canada,   Roche Diagnostics,   Ottawa Heart Institute Research Corporation
Recruiting Avoid Transvenous Leads in Appropriate Subjects
  • Interventions: Device Implantable Cardioverter Defibrillator
  • Sponsor: Population Health Research Institute,   Boston Scientific Corporation
Recruiting Milrinone Versus Dobutamine in Critically Ill Patients
  • Conditions: Low Cardiac Output Syndrome,   Cardiogenic Shock,   Acute Coronary Syndrome,   Pulmonary Edema
Recruiting A Novel Strategy For Personalized Long-Term Dual Antiplatelet Therapy (RAPID EXTEND)
  • Conditions: Stable Coronary Syndrome,   Percutaneous Coronary Intervention,   Antiplatelet Therapy,   Ticagrelor
Recruiting Sub-Clinical Atrial Fibrillation Biomarker Study
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Population Health Research Institute,   Genome Canada,   Bristol-Myers Squibb,   Pfizer,   Medtronic,   Canadian Institutes of Health Research (CIHR)
Recruiting Detection of Atrial Fibrillation After Cardiac Surgery
  • Conditions: Atrial Fibrillation,   Atrial Flutter,   C.Surgical Procedure, Cardiac,   Arrhythmias, Cardiac
Recruiting Hybrid Coronary Revascularization Trial
  • Sponsor: Emilia Bagiella,   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting Effect of Pre-op NRT on Peri-operative Complications and Long-term Abstinence: A Pilot Trial in Patients Undergoing CABG Surgery
  • Interventions: Drug Nicoderm Patch
Recruiting FIBrinogen REplenishment in Surgery
Recruiting Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs
  • Sponsor: Northern Therapeutics,   Ottawa Hospital Research Institute
Recruiting Personalized Dosing of Nicotine Replacement (NRT to Effect)
  • Conditions: Tobacco Use Disorder,   Nicotine Dependence
  • Sponsor: Centre for Addiction and Mental Health,   Canadian Cancer Society Research Institute (CCSRI),   Ottawa Heart Institute Research Corporation
Recruiting Cardiovascular Prehabilitation in Patients Awaiting Heart Transplantation (PREHAB HTx Study)
  • Interventions: Behavioral High-Intensity Interval Training
Recruiting Comparing Hypothermic Temperatures During Hemiarch Surgery
  • Interventions: Procedure Hypothermic circulatory arrest
Recruiting Ticagrelor Antiplatelet Therapy to Reduce Graft Events and Thrombosis
  • Sponsor: Boca Raton Regional Hospital,   AstraZeneca,   Ottawa Heart Institute Research Corporation
Recruiting Feasibility and Usability of a Pedometer in a Cardiovascular Disease Prevention Program for French-speaking Canadians
  • Interventions: Device PiezoRx medical grade pedometer
  • Sponsor: Ottawa Heart Institute Research Corporation,   StepsCount Inc
Recruiting Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Heart and Stroke Foundation of Canada
Recruiting Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial
  • Sponsor: Lawson Health Research Institute,   Medtronic
Recruiting Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
  • Conditions: Diabetes Mellitus,   Coronary Artery Disease
  • Interventions: Device Pressure Wire Certus, St. Jude Medical, USA
Recruiting 99mTc-rhAnnexin V-128 Imaging and Cardiotoxicity in Patients With Early Breast Cancer
  • Conditions: Breast Cancer,   Doxorubicin Induced Cardiomyopathy
  • Interventions: Radiation 99mTc-rhAnnexin V-128
Recruiting Mobilization of Endothelial Progenitor Cells and Aspirin
  • Interventions: Drug Aspirin
Recruiting 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
  • Interventions: Radiation 99mTc-rhAnnexin V-128
Recruiting Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training
Recruiting Exercise Training in Patients With Atrial Fibrillation (OPPORTUNITY Study)
Recruiting Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Population Health Research Institute,   Bristol-Myers Squibb,   Pfizer,   Medtronic,   Canadian Institutes of Health Research (CIHR),   Hamilton Health Sciences Research Institute,   Hamilton Health Sciences Foundation
Recruiting The Canadian Mitral Research Alliance (CAMRA) Trial CardioLink-2
  • Sponsor: St. Michael's Hospital, Toronto,   Ottawa Heart Institute Research Corporation,   London Health Sciences Centre
Recruiting Randomized On-X Anticoagulation Trial
  • Sponsor: On-X Life Technologies, Inc.,   Clinipace LTD,   Alere, Inc.
Recruiting Canadian SCAD Study
  • Interventions: 
  • Sponsor: Cardiology Research UBC,   Canadian Institutes of Health Research (CIHR)
Recruiting Impact of Preoperative FFR on Arterial Bypass Graft Functionality
  • Interventions: Procedure Fractional Flow Reserve (FFR)
Recruiting Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation
  • Conditions: Heart Disease,   Congestive Heart Failure,   Atrial Fibrillation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
  • Sponsor: Laval University,   University Hospital, Brest
Recruiting Tailored Antiplatelet Therapy Following PCI
  • Conditions: Coronary Artery Disease,   Acute Coronary Syndrome,   Stenosis
  • Sponsor: Mayo Clinic,   Spartan Bioscience Inc.,   Applied Health Research Centre,   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting Cardiac Sarcoidosis Multi-Center Prospective Cohort
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Canadian Institutes of Health Research (CIHR)
Recruiting HYbrid CoronAry Revascularization in DiabeticS
  • Conditions: Diabetes,   Heart Disease
Recruiting Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV
  • Sponsor: Dr. Bob Sheldon,   Vanderbilt University
Recruiting Use of Glidesheath Slender to Reduce Radial Artery Occlusion and Vascular Access Site Complications Following Transradial Coronary Angiography
  • Conditions: Embolism and Thrombosis of the Radial Artery,   Coronary Heart Disease
Recruiting Femoral Versus Radial Access for Primary PCI
  • Conditions: Myocardial Infarction,   STEMI
  • Interventions: Procedure Primary Percutaneous Coronary Intervention (PPCI)
Recruiting Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
  • Interventions: Other single photon emission computed tomography
  • Sponsor: Ottawa Heart Institute Research Corporation,   GE Healthcare
Recruiting IMAGE-HF Project I-A: Cardiac Imaging in Ischemic Heart Failure (AIMI-HF)
  • Conditions: Heart Failure,   Coronary Artery Disease,   Ischemic Cardiomyopathy,   Non-ischemic Cardiomyopathy
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   The Finnish Funding Agency for Technology and Innovation (TEKES)
Recruiting The Effects of Statin Therapy on Coronary Flow Reserve and Inflammatory Markers in HIV-Positive Patients
  • Conditions: Human Immunodeficiency Virus (HIV),   Cardiovascular Disease (CVD)
  • Interventions: Drug Rosuvastatin
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario HIV Treatment Network
Recruiting Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure
  • Conditions: Sleep Apnea,   Heart Failure
  • Interventions: Device Adaptive Servo Ventilation
  • Sponsor: Toronto Rehabilitation Institute,   Canadian Institutes of Health Research (CIHR),   Philips Respironics
Recruiting A Pilot Study Evaluating Heart and Lung Metabolism in Pulmonary Hypertension Associated With Left Heart Disease
  • Interventions: Radiation FDG PET scan
Recruiting The Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial
  • Sponsor: Ottawa Hospital Research Institute,   Canadian Institutes of Health Research (CIHR),   Stem Cell Network
Recruiting Correlation of the Arrhythmia Mechanism and Substrate to Ablate Persistent Atrial Fibrillation Study
  • Interventions: Procedure Catheter ablation
Recruiting Cardiac FDG PET Viability Registry
  • Conditions: Heart Failure,   Ischemic Heart Disease,   Myocardial Dysfunction
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care
Recruiting Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   Bayer,   Biotronik SE & Co. KG
Recruiting Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
  • Conditions: Myocardial Infarction,   Sudden Death
  • Sponsor: University of Calgary,   Canadian Institutes of Health Research (CIHR),   Alberta Innovation and Science,   Medtronic,   GE Healthcare
Recruiting Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence
Recruiting Rubidium Elution System Performance Testing
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Jubilant DraxImage Inc.
Recruiting ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
  • Conditions: Heart Failure,   Obstructive Sleep Apnea,   Central Sleep Apnea
  • Interventions: Other [C11]Acetate and HED PET
Recruiting SodiUm SeleniTe Administration IN Cardiac Surgery (SUSTAIN CSX®-Trial).
  • Sponsor: Daren K. Heyland,   biosyn Arzneimittel GmbH,   Queen's University,   RWTH Aachen University
Recruiting Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
  • Interventions: Other Therapeutic Hypothermia

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