PET Research Radiochemistry

The mission of the UOHI PET Research Radiochemistry Laboratory is to provide the UOHI, the University of Ottawa and Greater Ottawa region with an onsite core facility that can offer a bench to bedside production/service, providing quality PET Radiopharmaceuticals for research projects in radiochemistry, targetry, animal-models and human imaging. Our goal is to produce novel and established PET Radiopharmaceuticals for innovative research to help understand and guide novel therapies in cardiovascular, kidney, diabetes, oncology and neuroscience diseases. Our lab offers the capability for research on basic radiochemistry to develop novel PET probes with the ultimate goal of translational work in humans to address scientific questions via PET imaging.

Services

Radiotracer Application in Cardiology Other Potential Applications

13N-Ammonia

Myocardial blood flow

Animal and human MBF quantification

Renal perfusion

18F-NaF

 

Arterial calcific/plaque imaging

atherosclerosis

Bone cancer

18F-FTHA

Free fatty acid uptake

PAH patients and animal models

Other animal models such as MLIP +/+, +/-, -/- mice

Skeletal muscle anomalies

11C-HED

SNS innervations

Sleep apnea study

Heart failure

Atrial fibrillation

Evaluation of neuronal integrity (examination of tumors of the sympathetic nervous systems)

11C-Acetate

MBF

Myocardial oxygen consumption

Myocardial perfusion

Oxidative metabolism

Cardiac efficiency

Renal perfusion

Prostate cancer
Hepatocellular carcinoma (HCC)

Renal cell carcinoma (RCC)

Bladder carcinoma

Brain tumors

Multiple myeloma

MBF in kidney

11C-Rolipram

PDE4 ligand

Heart failure

 

18F-FPyKYNE-Losartan

AT1 receptor uptake

Heart failure, hypertension

Diabetes, renal diseases

18F-HFB

Cell regenerative therapy

Cell regenerative therapy

Direct Cell Labelling

18F-FPyKYNE-c(RGDyK)

αVβ3 Integrin Receptor

Inflammation

Inflammation

11C-methyl-Hydroxyfasudil

Rho-Kinase ligand

Inflammation, heart failure, hypertension

Diabetes

11C-Carfentanil

 

Opioid Receptor ligand

Mental disorders

User Fee Schedule: Prices in effect for all grants receiving funding approval after June 30, 2015.

PER-CLINICAL IMAGING External User Internal User Pilot studies (Maximum 10 doses)
  Complete synthesis Shared dose* Complete synthesis Shared dose* Complete synthesis Shared dose*
NaF

350

20 300 16 240 16
NH3

250

20 120 16 112 16
Acetate

450

20 400 16 200 16
HED

800

20 650 16 360 16
FTHA

750

50 700 40 600 40
F-Losartan

1,400

200 1,000 180 800 180
Rolipram

800

150 700 120 600 120

*piggy backed to human clinical research production run

HUMAN CLINICAL and LARGE ANIMAL IMAGING RESEARCH Industry rate External Peer Review

Internal Peer Review

Pilot studies (Maximum 10 doses)

NaF

1,200 350 300 240

NH3

1,000 250 120 112

Acetate

800 450 400 200

HED

1,350 800 650 360

FTHA

2,250 750 700 600

F-Losartan

3,400 1,400 1,000 800

Prices listed above are subject to change as the development of new tracers is done on a time and materials charge basis.

List of Equipment

Siemens CTI Eclipse HP/RD Hybrid Cyclotron, GE Tracerlab MX (coincidence), GE Tracerlab FX F-N, GE Tracerlab FX C-Pro, CTI ASM Methylation Module, CTI ASM Methyl Iodine Acetate Module, Siemens Explora FDG4, MediSMARTS Radiation Monitoring System, Von Gahlen Hot cells, SRI Gas Chromatography System, Radio-TLC Imaging Scanner, Agilent HPLC, Agilent GC, Multi-Channel Analyzer (MCA), Laminar Flow Hoods and Biological Safety Cabinets, Capintec Dose Calibrators, Mettler Toledo Balance, Millipore Water Deionizer, Analytical and Semi-preparative HPLC Systems (Waters), Rotary Evaporator

Contact

For service requests and more information please contact:

Acting Core Facility Director: Tayebeh Hadizad, PhD
Email: Thadizad@ottawaheart.ca

Facility Staff Members

Share This