Messika-Zeitoun, David

Dr. Messika-Zeitoun is a cardiologist in the Division of Cardiology at the University of Ottawa Heart Institute and a full professor in the Faculty of Medicine at the University of Ottawa.


Dr. Messika-Zeitoun was born in France. He graduated from medical school at the Université Paris VI Université Pierre-et-Marie-Curie in 1992. He completed his training in cardiology in Paris and became an assistant professor at Tenon Hospital in 1999. After a two-year research fellowship at the Mayo Clinic from 2001 to 2003, he returned to Paris to work at the Bichat Hospital as a staff member in the Division of Cardiology. He completed his PhD in 2009 and was appointed to full professor of cardiology in 2013. He was appointed as staff cardiologist and clinician investigator in the Division of Cardiology at the University of Ottawa Heart Institute in 2018.

  • Fellow of the European Society of Cardiology, European Society of Cardiology
  • Member of the Canadian Cardiovascular Society
  • Member of the Canadian Society of Echocardiography
  • Member of the American Society of Echocardiography
  • Associate Editor of the European Heart Journal (2020)
  • UOHIAMO Dr. Martin Green Academic Award for Research (2019)

Research and clinical interests

Dr. Messika-Zeitoun is a non-invasive cardiologist specialized in echocardiography and valvular heart disease. He has a special interest in imaging and new transcatheter therapies. Dr. Messika-Zeitoun is leading the Centre for Valvular Heart Disease.


See current publications list at PubMed.

Selected publications:

  • Dreyfus J, Flagiello M, Bazire B, Eggenspieler F, Viau F, Riant E, Mbaki Y, Bohbot Y, Eyharts D, Senage T, Dubrulle H, Nicol M, Doguet F, Nguyen V, Coisne A, Le Tourneau T, Lavie-Badie Y, Tribouilloy C, Donal E, Tomasi J, Habib G, Selton-Suty C, Raffoul R, Iung B, Obadia JF, Messika-Zeitoun D. Isolated tricuspid valve surgery: impact of aetiology and clinical presentation on outcomes. Eur Heart J. 2020 in press
  • Messika-Zeitoun D, Iung B, Armoiry X, Trochu JN, Donal E, Habib G, Brochet E, Thibault H, Piriou N, Cormier B, Tribouilloy C, Guerin P, Lefèvre T, Maucort- Boulch D, Vahanian A, Boutitie F, Obadia JF. Impact of Mitral Regurgitation Severity and Left Ventricular Remodeling on Outcome After Mitraclip Implantation: Results From the Mitra-FR Trial. JACC Cardiovasc Imaging. 2020 in press
  • Messika-Zeitoun D, Candolfi P, Vahanian A, Chan V, Burwash IG, Philippon JF, Toussaint JM, Verta P, Feldman TE, Iung B, Glineur D, Mesana T, Enriquez-Sarano M. Dismal Outcomes and High Societal Burden of Mitral Valve Regurgitation in France in the Recent Era: A Nationwide Perspective. J Am Heart Assoc. 2020 Aug 4;9(15):e016086. doi: 10.1161/JAHA.120.016086.
  • Messika-Zeitoun D, Verta P, Gregson J, Pocock SJ, Boero I, Feldman TE, Abraham WT, Lindenfeld J, Bax J, Leon M, Enriquez-Sarano M. Impact of tricuspid regurgitation on survival in patients with heart failure: a large electronic health record patient-level database analysis. Eur J Heart Fail. 2020 in press
  • Messika-Zeitoun D, Burwash IG, Mesana T. EDUCATIONAL SERIES ON THE SPECIALIST VALVE CLINIC: Challenges in the diagnosis and management of valve disease: the case for the specialist valve clinic. Echo Res Pract. 2019 Dec 1;6(4):T1-T6.
  • Frey N, Steeds RP, Rudolph TK, Thambyrajah J, Serra A, Schulz E, Maly J, Aiello M, Lloyd G, Bortone AS, Hauptmann KE, Clerici A, Delle Karth G, Rieber J, Indorfi C, Mancone M, Belle L, Lauten A, Arnold M, Bouma BJ, Lutz M, Pohlmann C, Kurucova J, Thoenes M, Bramlage P, Messika-Zeitoun D; IMPULSE registry group. Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis. Heart. 2019 Nov;105(22):1709-1716.
  • Messika-Zeitoun D, Nickenig G, Latib A, Kuck KH, Baldus S, Schueler R, La Canna G, Agricola E, Kreidel F, Huntgeburth M, Zuber M, Verta P, Grayburn P, Vahanian A, Maisano F. Transcatheter mitral valve repair for functional mitral regurgitation using the Cardioband system: 1 year outcomes. Eur Heart J. 2019 Feb 1;40(5):466-472.
  • Obadia JF, Messika-Zeitoun D, Leurent G, Iung B, Bonnet G, Piriou N, Lefèvre T, Piot C, Rouleau F, Carrié D, Nejjari M, Ohlmann P, Leclercq F, Saint Etienne C, Teiger E, Leroux L, Karam N, Michel N, Gilard M, Donal E, Trochu JN, Cormier B, Armoiry X, Boutitie F, Maucort-Boulch D, Barnel C, Samson G, Guerin P, Vahanian A, Mewton N; MITRA-FR Investigators. Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation. N Engl J Med. 2018 Dec 13;379(24):2297-2306.
  • Nguyen V, Michel M, Eltchaninoff H, Gilard M, Dindorf C, Iung B, Mossialos E, Cribier A, Vahanian A, Chevreul K, Messika-Zeitoun D. Implementation of Transcatheter Aortic Valve Replacement in France. J Am Coll Cardiol. 2018 Apr 17;71(15):1614-1627.
  • Goublaire C, Melissopoulou M, Lobo D, Kubota N, Verdonk C, Cimadevilla C, Codogno I, Brochet E, Vahanian A, Messika-Zeitoun D. Prognostic Value of Exercise-Stress Echocardiography in Asymptomatic Patients With Aortic Valve Stenosis. JACC Cardiovasc Imaging. 2018 Jun;11(6):787-795.
Dr. David Messika-Zeitoun, UOHI

Messika-Zeitoun, David

Messika-Zeitoun, David


Appointments and affiliations

Valve team

Valvular Heart Diseases Innovation Hub 

Centre for Valvular Heart Disease
University of Ottawa Heart Institute

Division of Cardiology
Department of Medicine
University of Ottawa