Benjamin Rotstein, PhD, is Assistant Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa and Director of the Molecular Imaging Probes and Radiochemistry Laboratory at the University of Ottawa Heart Institute.
Dr. Rotstein obtained his BSc from Dalhousie University and the University of King’s College, Halifax, NS, and his PhD in Organic Chemistry from University of Toronto. His doctoral research focused on the reactivity of amphoteric molecules and their applications in macrocyclization of peptides. He then pursued postdoctoral training in radiochemistry and molecular imaging at Harvard Medical School and Massachusetts General Hospital, where he was promoted to faculty in 2015. During his postdoctoral work, he discovered spirocyclic iodonium ylides for radiofluorination and contributed to the development of new enzyme and receptor tracers for positron emission tomography.
Dr. Rotstein’s previous training was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) in the form of postgraduate scholarships and a Postdoctoral Fellowship. He has recently received Young Investigator Awards from the Society of Nuclear Medicine and Molecular Imaging as well as the Alzheimer’s Drug Discovery Foundation (ADDF). Dr. Rotstein has served as a referee for several organic and medicinal chemistry journals. In 2016, he has been a Co-Investigator on project grants from the ADDF and the Michael J. Fox Foundation for Parkinson’s Research.
Research in the Molecular Imaging Probes and Radiochemistry Laboratory is directed towards the discovery of radiopharmaceuticals for both studying and diagnosis of disease conditions, and facilitating therapeutic development through the measurement of in vivo molecular target-ligand interactions. Specific cardiovascular imaging targets include biomarkers and therapeutic targets for atherosclerosis, arrhythmias, and heart failure. In support of these goals we develop innovative radiochemical methodologies for small molecule radiolabeling and bioconjugation with short-lived isotopes such as carbon-11 and fluorine-18.
See current publications list at PubMed.
Selected publications :
- Rotstein, BH; Liang, SH; Placzek, MS; Hooker, JM; Gee, AD; Dollé, F; Wilson, AA; Vasdev, N. “11C═O bonds made easily for positron emission tomography.” Chem. Soc. Rev. 2016, In Press. doi: 10.1039/C6CS00310A.
- Rotstein, BH; Wang, L; Liu, RY; Patteson, J; Kwan, EE: Vasdev, N; Liang, SH. “Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(III) ylides.” Chem. Sci. 2016, 7, 4407–4417.
- Wang, L; Jacobsen, O; Advic, D; Rotstein, BH; Weiss ID; Collier TL; Chen X; Vasdev, N; Liang, SH. “Ortho-stabilized 18F-azide click agents and application in PET imaging of single-stranded DNA aptamer.” Angew. Chem. Int. Ed. 2015, 54, 12777–12781.
- Rotstein, BH; Stephenson, NA; Vasdev, N; Liang, SL. “Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics.” Nature Commun. 2014, 5, 4365. doi: 10.1038/ncomms5365.
- Rotstein, BH; Wey, H-Y; Shoup, TM; Wilson, AA; Liang, SH; Hooker, JM; Vasdev, N. “PET imaging of fatty acid amide hydrolase with [18F]DOPP in non-human primates.” Mol. Pharmaceutics 2014, 11, 3832–3838.
- Rotstein, BH; Hooker, JM; Woo, J; Collier, TL; Brady, TJ; Liang, SH; Vasdev, N. “Synthesis of [11C]bexarotene by Cu‑mediated [11C]carbon dioxide fixation and preliminary PET imaging.” ACS Med. Chem. Lett. 2014, 5, 668–672.
- Rotstein, BH; Zaretsky, S; Rai, V; Yudin, AK. “Small ring heterocycles in multicomponent reactions.” Chem. Rev. 2014, 114, 8323–8359.
- Rotstein, BH; Winternheimer, DJ; Yin, LM; Deber, CM; Yudin, AK. “Thioester-isocyanides: Versatile reagents for the synthesis of cycle-tail peptides.” Chem. Commun. 2012, 48, 3775–3777.
- Rotstein, BH; Mourtada, R; Kelley, SO; Yudin, AK. “Solvatochromic reagents for multicomponent reactions and their utility in the development of cell-permeable macrocyclic peptide vectors.” Chem. Eur. J. 2011, 17, 12257–12261.
- Rotstein, BH; Rai, V; Hili, R; Yudin, AK. “Synthesis of peptide macrocycles using unprotected amino aldehydes.” Nature Protoc. 2010, 5, 1813–1822.