Rotstein, Benjamin


Benjamin Rotstein, PhD, is Assistant Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa and Director of the Molecular Imaging Probes and Radiochemistry Laboratory at the University of Ottawa Heart Institute.


Dr. Rotstein obtained his BSc from Dalhousie University and the University of King’s College, Halifax, NS, and his PhD in Organic Chemistry from University of Toronto. His doctoral research focused on the reactivity of amphoteric molecules and their applications in macrocyclization of peptides. He then pursued postdoctoral training in radiochemistry and molecular imaging at Harvard Medical School and Massachusetts General Hospital, where he was promoted to faculty in 2015. During his postdoctoral work, he discovered spirocyclic iodonium ylides for radiofluorination and contributed to the development of new enzyme and receptor tracers for positron emission tomography.

Dr. Rotstein’s previous training was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) in the form of postgraduate scholarships and a Postdoctoral Fellowship. He has recently received Young Investigator Awards from the Society of Nuclear Medicine and Molecular Imaging as well as the Alzheimer’s Drug Discovery Foundation (ADDF). Dr. Rotstein has served as a referee for several organic and medicinal chemistry journals. In 2016, he has been a Co-Investigator on project grants from the ADDF and the Michael J. Fox Foundation for Parkinson’s Research.

Research & Clinical Interests 

Research in the Molecular Imaging Probes and Radiochemistry Laboratory is directed towards the discovery of radiopharmaceuticals for both studying and diagnosis of disease conditions, and facilitating therapeutic development through the measurement of in vivo molecular target-ligand interactions. Specific cardiovascular imaging targets include biomarkers and therapeutic targets for atherosclerosis, arrhythmias, and heart failure. In support of these goals we develop innovative radiochemical methodologies for small molecule radiolabeling and bioconjugation with short-lived isotopes such as carbon-11 and fluorine-18.


See current publications list at PubMed.

Selected publications :

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